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Michael R. Hughes
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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
BS Freedman, CR Brooks, AQ Lam, H Fu, R Morizane, V Agrawal, ...
Nature communications 6 (1), 8715, 2015
7222015
The molecular basis of vascular lumen formation in the developing mouse aorta
B Strilić, T Kučera, J Eglinger, MR Hughes, KM McNagny, S Tsukita, ...
Developmental cell 17 (4), 505-515, 2009
4262009
Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids
A Cait, MR Hughes, F Antignano, J Cait, PA Dimitriu, KR Maas, ...
Mucosal immunology 11 (3), 785-795, 2018
3062018
Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for Protein Kinase B (PKB) activation; Phosphatidylinositol (3, 4) P2 is required for PKB phosphorylation at …
MP Scheid, M Huber, JE Damen, M Hughes, V Kang, P Neilsen, ...
Journal of Biological Chemistry 277 (11), 9027-9035, 2002
2252002
The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of …
L Liu, JE Damen, MR Hughes, I Babic, FR Jirik, G Krystal
Journal of Biological Chemistry 272 (14), 8983-8988, 1997
1741997
Protein kinase C-δ is a negative regulator of antigen-induced mast cell degranulation
M Leitges, K Gimborn, W Elis, J Kalesnikoff, MR Hughes, G Krystal, ...
Molecular and cellular biology 22 (12), 3970-3980, 2002
1632002
SHIP negatively regulates IgE+ antigen-induced IL-6 production in mast cells by inhibiting NF-κB activity
J Kalesnikoff, N Baur, M Leitges, MR Hughes, JE Damen, M Huber, ...
The Journal of Immunology 168 (9), 4737-4746, 2002
1612002
Gene-edited human kidney organoids reveal mechanisms of disease in podocyte development
YK Kim, I Refaeli, CR Brooks, P Jing, RE Gulieva, MR Hughes, NM Cruz, ...
Stem cells 35 (12), 2366-2378, 2017
1392017
The role of SHIP in cytokine-induced signaling
VLAMM Huber, G Krystal
Reviews of Physiology, Biochemistry and Pharmacology 149, 87-103, 2004
139*2004
DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis
I Elisia, H Nakamura, V Lam, E Hofs, R Cederberg, J Cait, MR Hughes, ...
PloS one 11 (3), e0152538, 2016
1192016
DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis
I Elisia, H Nakamura, V Lam, E Hofs, R Cederberg, J Cait, MR Hughes, ...
PloS one 11 (3), e0152538, 2016
1192016
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
F Antignano, K Burrows, MR Hughes, JM Han, KJ Kron, NM Penrod, ...
The Journal of clinical investigation 124 (5), 1945-1955, 2014
1052014
The role of SHIP1 in macrophage programming and activation
MJ Rauh, LM Sly, J Kalesnikoff, MR Hughes, LP Cao, V Lam, G Krystal
Biochemical Society Transactions 32 (5), 785-788, 2004
1052004
SETD7 controls intestinal regeneration and tumorigenesis by regulating Wnt/β-catenin and Hippo/YAP signaling
MJ Oudhoff, MJS Braam, SA Freeman, D Wong, DG Rattray, J Wang, ...
Developmental cell 37 (1), 47-57, 2016
1012016
SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation
JE Damen, MD Ware, J Kalesnikoff, MR Hughes, G Krystal
Blood, The Journal of the American Society of Hematology 97 (5), 1343-1351, 2001
992001
Butyrate shapes immune cell fate and function in allergic asthma
W Yip, MR Hughes, Y Li, A Cait, M Hirst, WW Mohn, KM McNagny
Frontiers in Immunology 12, 628453, 2021
942021
SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens
HP Sham, EYS Yu, MF Gulen, G Bhinder, M Stahl, JM Chan, L Brewster, ...
PLoS pathogens 9 (8), e1003539, 2013
932013
Role of Src homology 2-containing-inositol 5′-phosphatase (SHIP) in mast cells and macrophages
MJ Rauh, J Kalesnikoff, M Hughes, L Sly, V Lam, G Krystal
Biochemical Society Transactions 31 (1), 286-291, 2003
832003
The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease
BC Lo, MJ Gold, MR Hughes, F Antignano, Y Valdez, C Zaph, KW Harder, ...
Science immunology 1 (3), eaaf8864-eaaf8864, 2016
812016
Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy
KA Snyder, MR Hughes, B Hedberg, J Brandon, DC Hernaez, P Bergqvist, ...
Breast cancer research 17, 1-14, 2015
772015
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