Pavel Savechenkov
Pavel Savechenkov
Medicinal Chemist
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Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor*♦
DC Chiara, SS Jayakar, X Zhou, X Zhang, PY Savechenkov, KS Bruzik, ...
Journal of Biological Chemistry 288 (27), 19343-19357, 2013
Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog*♦
SS Jayakar, X Zhou, DC Chiara, Z Dostalova, PY Savechenkov, KS Bruzik, ...
Journal of Biological Chemistry 289 (40), 27456-27468, 2014
Anion Binding Modes in meso-Substituted Hexapyrrolic Calix[4]pyrrole Isomers
KC Chang, T Minami, P Koutnik, PY Savechenkov, Y Liu, ...
Journal of the American Chemical Society 136 (4), 1520-1525, 2014
p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol
DS Stewart, PY Savechenkov, Z Dostalova, DC Chiara, R Ge, DE Raines, ...
Journal of medicinal chemistry 54 (23), 8124-8135, 2011
Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic
PY Savechenkov, X Zhang, DC Chiara, DS Stewart, R Ge, X Zhou, ...
Journal of medicinal chemistry 55 (14), 6554-6565, 2012
Anion sensing by fluorescent expanded calixpyrroles
M Pushina, P Koutnik, R Nishiyabu, T Minami, P Savechenkov, ...
Chemistry–A European Journal 24 (19), 4879-4884, 2018
Positive and negative allosteric modulation of an α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor by binding to a site in the transmembrane domain at the γ+-β− interface
SS Jayakar, X Zhou, PY Savechenkov, DC Chiara, R Desai, KS Bruzik, ...
Journal of Biological Chemistry 290 (38), 23432-23446, 2015
Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H] allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate
AK Hamouda, DS Stewart, DC Chiara, PY Savechenkov, KS Bruzik, ...
Molecular Pharmacology 85 (5), 735-746, 2014
Identifying drugs that bind selectively to intersubunit general anesthetic sites in the α1β3γ2 GABAAR transmembrane domain
SS Jayakar, X Zhou, DC Chiara, C Jarava-Barrera, PY Savechenkov, ...
Molecular pharmacology 95 (6), 615-628, 2019
General anesthetic binding sites in human α4β3δ γ-aminobutyric acid type A receptors (GABAARs)
DC Chiara, Y Jounaidi, X Zhou, PY Savechenkov, KS Bruzik, KW Miller, ...
Journal of Biological Chemistry 291 (51), 26529-26539, 2016
Reactions of Vinyl Type Carbocations Generated in Fluorosulfonic Acid with Benzene Derivatives. New Synthesis of Alkyl 3,3-Diarylpropenoates
PY Savechenkov, AP Rudenko, AV Vasil'ev, GKR Fukin
Russ. J. Org. Chem. 41, 1316–1328, 2005
Protonation of 3-Arylpropynoic Acid Derivatives in Superacids.
S Walspurger, AV Vasil’ev, J Sommer, P Pale, ...
Russ. J. Org. Chem. 41, 1485–1492, 2005
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands
PY Savechenkov, DC Chiara, R Desai, AT Stern, X Zhou, AM Ziemba, ...
European journal of medicinal chemistry 136, 334-347, 2017
Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo
DE Kent, PY Savechenkov, KS Bruzik, KW Miller
British Journal of Pharmacology 176 (24), 4760-4772, 2019
A Novel Dimerization of Methyl p-Tolylpropynoate in Fluorosulfonic Acid with Conservation of the Triple Bond
PY Savechenkov, AP Rudenko, AV Vasil’ev
Russ. J. Org. Chem. 40, 1065–1066, 2004
Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects
R Desai, PY Savechenkov, D Zolkowska, RL Ge, MA Rogawski, KS Bruzik, ...
The Journal of physiology 593 (22), 4943-4961, 2015
Oxidation of aromatic compounds: XII. Regio- and stereoselective oxidative dimerization of alkyl 3-Arylpropynoates in the system CF3CO2H-CH2Cl2-PbO2
PY Savechenkov, AV Vasil’ev, AP Rudenko
Russ. J. Org. Chem. 40, 1279–1283, 2004
Nitration of Phenylpropiolic acid derivatives in HSO3F and reactions of vinyl type cations formed therefrom
PY Savechenkov, AP Rudenko, AV Vasil’ev
Russ. J. Org. Chem. 40, 1633–1637, 2004
Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors
B Wu, SS Jayakar, X Zhou, K Titterton, DC Chiara, AL Szabo, ...
European journal of medicinal chemistry 162, 810-824, 2019
Stereoselective synthesis of methyl 3,3-Diarylpropenoates
AP Rudenko, PY Savechenkov, AV Vasil’ev
Russ. J. Org. Chem. 40, 1377–1378, 2004
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