| A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic T Shapira, IA Monreal, SP Dion, DW Buchholz, B Imbiakha, AD Olmstead, ... Nature 605 (7909), 340-348, 2022 | 137 | 2022 |
| Probing the substrate specificities of matriptase, matriptase‐2, hepsin and DESC1 with internally quenched fluorescent peptides F Béliveau, A Désilets, R Leduc The FEBS journal 276 (8), 2213-2226, 2009 | 119 | 2009 |
| Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis JM Milner, A Patel, RK Davidson, TE Swingler, A Desilets, DA Young, ... Arthritis & Rheumatism 62 (7), 1955-1966, 2010 | 104 | 2010 |
| Microbiota-centered interventions: the next breakthrough in immuno-oncology? L Derosa, B Routy, A Desilets, R Daillère, S Terrisse, G Kroemer, ... Cancer Discovery 11 (10), 2396-2412, 2021 | 96 | 2021 |
| Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium A Beaulieu, É Gravel, A Cloutier, I Marois, É Colombo, A Désilets, ... Journal of virology 87 (8), 4237-4251, 2013 | 94 | 2013 |
| Design and synthesis of potent, selective inhibitors of matriptase É Colombo, A Désilets, D Duchêne, F Chagnon, R Najmanovich, R Leduc, ... ACS Medicinal Chemistry Letters 3 (7), 530-534, 2012 | 75 | 2012 |
| Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway MS Buzza, EW Martin, KH Driesbaugh, A Désilets, R Leduc, TM Antalis Journal of Biological Chemistry 288 (15), 10328-10337, 2013 | 65 | 2013 |
| Matriptase protects against experimental colitis and promotes intestinal barrier recovery S Netzel-Arnett, MS Buzza, T Shea-Donohue, A Désilets, R Leduc, ... Inflammatory bowel diseases 18 (7), 1303-1314, 2012 | 62 | 2012 |
| Inhibition of human matriptase by eglin c variants A Désilets, JM Longpré, MÈ Beaulieu, R Leduc FEBS letters 580 (9), 2227-2232, 2006 | 57 | 2006 |
| Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease A Désilets, F Béliveau, G Vandal, FO McDuff, P Lavigne, R Leduc Journal of biological chemistry 283 (16), 10535-10542, 2008 | 56 | 2008 |
| The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover DJ Wilkinson, A Desilets, H Lin, S Charlton, M del Carmen Arques, ... Scientific reports 7 (1), 16693, 2017 | 36 | 2017 |
| The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction NJ Ronaghan, J Shang, V Iablokov, R Zaheer, P Colarusso, S Dion, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 311 (3 …, 2016 | 35 | 2016 |
| Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2 D Duchêne, E Colombo, A Désilets, PL Boudreault, R Leduc, E Marsault, ... Journal of Medicinal Chemistry 57 (23), 10198-10204, 2014 | 35 | 2014 |
| Inhibition by deacetylase inhibitors of IL-1-dependent induction of haptoglobin involves CCAAT/Enhancer-binding protein isoforms in intestinal epithelial cells A Désilets, I Gheorghiu, SJ Yu, EG Seidman, C Asselin Biochemical and biophysical research communications 276 (2), 673-679, 2000 | 33 | 2000 |
| Discovery and development of TMPRSS6 inhibitors modulating hepcidin levels in human hepatocytes F Béliveau, A Tarkar, SP Dion, A Désilets, MG Ghinet, PL Boudreault, ... Cell Chemical Biology 26 (11), 1559-1572. e9, 2019 | 31 | 2019 |
| Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality F Béliveau, C Brulé, A Désilets, B Zimmerman, SA Laporte, CL Lavoie, ... Journal of Biological Chemistry 286 (33), 29035-29043, 2011 | 28 | 2011 |
| IL-1β-dependent regulation of C/EBPδ transcriptional activity A Svotelis, G Doyon, G Bernatchez, A Désilets, N Rivard, C Asselin Biochemical and biophysical research communications 328 (2), 461-470, 2005 | 28 | 2005 |
| Attenuation of haptoglobin gene expression by TGFβ requires the MAP kinase pathway SJ Yu, F Boudreau, A Désilets, M Houde, N Rivard, C Asselin Biochemical and biophysical research communications 259 (3), 544-549, 1999 | 24 | 1999 |
| The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide E Lanchec, A Désilets, F Béliveau, A Flamier, S Mahmoud, G Bernier, ... Journal of Biological Chemistry 292 (50), 20669-20682, 2017 | 22 | 2017 |
| Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids C St-Georges, A Désilets, F Béliveau, M Ghinet, SP Dion, É Colombo, ... European Journal of Medicinal Chemistry 129, 110-123, 2017 | 22 | 2017 |
