| Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009 | 4568 | 2009 |
| Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation F Wang, J Travins, B DeLaBarre, V Penard-Lacronique, S Schalm, ... Science 340 (6132), 622-626, 2013 | 935 | 2013 |
| Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations S Gross Journal of Experimental Medicine 207 (2), 339-334, 2010 | 870 | 2010 |
| Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ... Nature 483 (7390), 484-488, 2012 | 821 | 2012 |
| AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations K Yen, J Travins, F Wang, MD David, E Artin, K Straley, A Padyana, ... Cancer discovery 7 (5), 478-493, 2017 | 413 | 2017 |
| Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers J Popovici-Muller, RM Lemieux, E Artin, JO Saunders, FG Salituro, ... ACS medicinal chemistry letters 9 (4), 300-305, 2018 | 382 | 2018 |
| MTAP deletions in cancer create vulnerability to targeting of the MAT2A/PRMT5/RIOK1 axis K Marjon, MJ Cameron, P Quang, MF Clasquin, E Mandley, K Kunii, ... Cell reports 15 (3), 574-587, 2016 | 342 | 2016 |
| Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast MM Kessler, MF Henry, E Shen, J Zhao, S Gross, PA Silver, CL Moore Genes & development 11 (19), 2545-2556, 1997 | 306 | 1997 |
| Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo J Popovici-Muller, JO Saunders, FG Salituro, JM Travins, S Yan, F Zhao, ... ACS medicinal chemistry letters 3 (10), 850-855, 2012 | 240 | 2012 |
| Small molecule activation of PKM2 in cancer cells induces serine auxotrophy C Kung, J Hixon, S Choe, K Marks, S Gross, E Murphy, B DeLaBarre, ... Chemistry & biology 19 (9), 1187-1198, 2012 | 193 | 2012 |
| Coupling of termination, 3′ processing, and mRNA export CM Hammell, S Gross, D Zenklusen, CV Heath, F Stutz, C Moore, ... Molecular and cellular biology, 2002 | 174 | 2002 |
| Full-length human glutaminase in complex with an allosteric inhibitor B DeLaBarre, S Gross, C Fang, Y Gao, A Jha, F Jiang, J Song J, W Wei, ... Biochemistry 50 (50), 10764-10770, 2011 | 162 | 2011 |
| Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I S Gross, C Moore Proceedings of the National Academy of Sciences 98 (11), 6080-6085, 2001 | 134 | 2001 |
| MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage P Kalev, ML Hyer, S Gross, Z Konteatis, CC Chen, M Fletcher, M Lein, ... Cancer Cell 39 (2), 209-224. e11, 2021 | 120 | 2021 |
| Rna15 interaction with the A-rich yeast polyadenylation signal is an essential step in mRNA 3′-end formation S Gross, CL Moore Molecular and cellular biology 21 (23), 8045-8055, 2001 | 113 | 2001 |
| Mutant IDH is sufficient to initiate enchondromatosis in mice M Hirata, M Sasaki, RA Cairns, S Inoue, V Puviindran, WY Li, BE Snow, ... Proceedings of the National Academy of Sciences 112 (9), 2829-2834, 2015 | 104 | 2015 |
| AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency C Kung, J Hixon, PA Kosinski, G Cianchetta, G Histen, Y Chen, C Hill, ... Blood, The Journal of the American Society of Hematology 130 (11), 1347-1356, 2017 | 102 | 2017 |
| Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase AK Padyana, S Gross, L Jin, G Cianchetta, R Narayanaswamy, F Wang, ... Nature communications 10 (1), 97, 2019 | 101 | 2019 |
| Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 MI Davis, S Gross, M Shen, KS Straley, R Pragani, WA Lea, ... Journal of Biological Chemistry 289 (20), 13717-13725, 2014 | 93 | 2014 |
| ALDH2 (E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis S Jin, J Chen, L Chen, G Histen, Z Lin, S Gross, J Hixon, Y Chen, C Kung, ... Proceedings of the National Academy of Sciences 112 (29), 9088-9093, 2015 | 89 | 2015 |
