Jean-Christophe Grenier
Jean-Christophe Grenier
Bioinformatician, Montreal Heart Institute, Montreal, Qc
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BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis
E Kaufmann, J Sanz, JL Dunn, N Khan, LE Mendonça, A Pacis, F Tzelepis, ...
Cell 172 (1-2), 176-190. e19, 2018
Social networks predict gut microbiome composition in wild baboons
J Tung, LB Barreiro, MB Burns, JC Grenier, J Lynch, LE Grieneisen, ...
Elife 4, e05224, 2015
Genetic ancestry and natural selection drive population differences in immune responses to pathogens
Y Nédélec, J Sanz, G Baharian, ZA Szpiech, A Pacis, A Dumaine, ...
Cell 167 (3), 657-669. e21, 2016
Bacterial infection remodels the DNA methylation landscape of human dendritic cells
A Pacis, L Tailleux, AM Morin, J Lambourne, JL MacIsaac, V Yotova, ...
Genome research 25 (12), 1801-1811, 2015
Social status alters immune regulation and response to infection in macaques
N Snyder-Mackler, J Sanz, JN Kohn, JF Brinkworth, S Morrow, AO Shaver, ...
Science 354 (6315), 1041-1045, 2016
High-resolution genomic analysis of human mitochondrial RNA sequence variation
A Hodgkinson, Y Idaghdour, E Gbeha, JC Grenier, E Hip-Ki, V Bruat, ...
Science 344 (6182), 413-415, 2014
Evidence for additive and interaction effects of host genotype and infection in malaria
Y Idaghdour, J Quinlan, JP Goulet, J Berghout, E Gbeha, V Bruat, ...
Proceedings of the National Academy of Sciences 109 (42), 16786-16793, 2012
Whole-exome sequencing reveals a rapid change in the frequency of rare functional variants in a founding population of humans
F Casals, A Hodgkinson, J Hussin, Y Idaghdour, V Bruat, T de Maillard, ...
PLoS Genet 9 (9), e1003815, 2013
Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers
GH Perry, M Foll, JC Grenier, E Patin, Y Nédélec, A Pacis, M Barakatt, ...
Proceedings of the National Academy of Sciences 111 (35), E3596-E3603, 2014
Recombination affects accumulation of damaging and disease-associated mutations in human populations
JG Hussin, A Hodgkinson, Y Idaghdour, JC Grenier, JP Goulet, E Gbeha, ...
Nature genetics 47 (4), 400-404, 2015
Gene activation precedes DNA demethylation in response to infection in human dendritic cells
A Pacis, F Mailhot-Léonard, L Tailleux, HE Randolph, V Yotova, ...
Proceedings of the National Academy of Sciences 116 (14), 6938-6943, 2019
Gene-by-environment interactions in urban populations modulate risk phenotypes
MJ Favé, FC Lamaze, D Soave, A Hodgkinson, H Gauvin, V Bruat, ...
Nature communications 9 (1), 1-12, 2018
Rare allelic forms of PRDM9 associated with childhood leukemogenesis
J Hussin, D Sinnett, F Casals, Y Idaghdour, V Bruat, V Saillour, J Healy, ...
Genome research 23 (3), 419-430, 2013
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease
T Mayassi, K Ladell, H Gudjonson, JE McLaren, DG Shaw, MT Tran, ...
Cell 176 (5), 967-981. e19, 2019
Widespread shortening of 3’untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection
AA Pai, G Baharian, A Pagé Sabourin, JF Brinkworth, Y Nédélec, ...
PLoS genetics 12 (9), e1006338, 2016
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease
V Abadie, SM Kim, T Lejeune, BA Palanski, JD Ernest, O Tastet, J Voisine, ...
Nature 578 (7796), 600-604, 2020
Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation
M Cao, M Cortes, CS Moore, S Leong, LD Durosier, P Burns, G Fecteau, ...
Frontiers in cellular neuroscience 9, 294, 2015
Relaxed selection during a recent human expansion
S Peischl, I Dupanloup, A Foucal, M Jomphe, V Bruat, JC Grenier, A Gouy, ...
Genetics 208 (2), 763-777, 2018
Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12
GA Orbelyan, F Tang, B Sally, J Solus, B Meresse, C Ciszewski, ...
The Journal of Immunology 193 (2), 610-616, 2014
Aortic dilatation associated with a de novo mutation in the SOX18 gene: expanding the clinical spectrum of hypotrichosis-lymphedema-telangiectasia syndrome
F Wünnemann, V Kokta, S Leclerc, M Thibeault, C McCuaig, A Hatami, ...
Canadian Journal of Cardiology 32 (1), 135. e1-135. e7, 2016
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