Translational activation of HIF1α by YB-1 promotes sarcoma metastasis AM El-Naggar, CJ Veinotte, H Cheng, TGP Grunewald, GL Negri, ... Cancer cell 27 (5), 682-697, 2015 | 312 | 2015 |
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance JKM Lim, A Delaidelli, SW Minaker, HF Zhang, M Colovic, H Yang, ... Proceedings of the National Academy of Sciences 116 (19), 9433-9442, 2019 | 229 | 2019 |
The H3K36me2 methyltransferase Nsd1 demarcates PRC2-mediated H3K27me2 and H3K27me3 domains in embryonic stem cells G Streubel, A Watson, SG Jammula, A Scelfo, DJ Fitzpatrick, G Oliviero, ... Molecular cell 70 (2), 371-379. e5, 2018 | 156 | 2018 |
Quantitative genetic-interaction mapping in mammalian cells A Roguev, D Talbot, GL Negri, M Shales, G Cagney, S Bandyopadhyay, ... Nature methods 10 (5), 432-437, 2013 | 130 | 2013 |
Eradication of B-ALL using chimeric antigen receptor–expressing T cells targeting the TSLPR oncoprotein H Qin, M Cho, W Haso, L Zhang, SK Tasian, HZ Oo, GL Negri, Y Lin, ... Blood, The Journal of the American Society of Hematology 126 (5), 629-639, 2015 | 129 | 2015 |
Class I HDAC inhibitors enhance YB‐1 acetylation and oxidative stress to block sarcoma metastasis AM El‐Naggar, SP Somasekharan, Y Wang, H Cheng, GL Negri, M Pan, ... EMBO reports 20 (12), e48375, 2019 | 84 | 2019 |
Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes K Asleh, GL Negri, SE Spencer Miko, S Colborne, CS Hughes, XQ Wang, ... Nature Communications 13 (1), 896, 2022 | 62 | 2022 |
The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level E Kwon, K Todorova, J Wang, R Horos, KK Lee, VA Neel, GL Negri, ... Nature communications 9 (1), 1734, 2018 | 62 | 2018 |
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity A Jan, B Jansonius, A Delaidelli, F Bhanshali, YA An, N Ferreira, ... Acta neuropathologica communications 6, 1-17, 2018 | 59 | 2018 |
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response A Jan, B Jansonius, A Delaidelli, SP Somasekharan, F Bhanshali, ... Acta Neuropathologica 133, 101-119, 2017 | 52 | 2017 |
Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in Ewing sarcoma HF Zhang, CS Hughes, W Li, JZ He, D Surdez, AM El-Naggar, H Cheng, ... Cancer discovery 11 (11), 2884-2903, 2021 | 51 | 2021 |
Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal G Streubel, DJ Fitzpatrick, G Oliviero, A Scelfo, B Moran, S Das, ... The EMBO journal 36 (15), 2216-2232, 2017 | 46 | 2017 |
Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine NM Cetinbas, J Sudderth, RC Harris, A Cebeci, GL Negri, ÖH Yılmaz, ... Scientific reports 6 (1), 32606, 2016 | 44 | 2016 |
Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma GL Negri, BM Grande, A Delaidelli, A El‐Naggar, D Cochrane, CC Lau, ... The Journal of pathology 249 (3), 319-331, 2019 | 42 | 2019 |
Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation E Gatev, AM Inkster, GL Negri, C Konwar, AA Lussier, A Skakkebaek, ... Nucleic Acids Research 49 (16), 9097-9116, 2021 | 33 | 2021 |
HACE1 is a potential tumor suppressor in osteosarcoma AM El-Naggar, PW Clarkson, GL Negri, B Turgu, F Zhang, MS Anglesio, ... Cell death & disease 10 (1), 21, 2019 | 31 | 2019 |
MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation A Delaidelli, GL Negri, A Jan, B Jansonius, A El-Naggar, JKM Lim, ... Cell Death & Differentiation 24 (9), 1564-1576, 2017 | 30 | 2017 |
High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8 MJ Aristizabal, GL Negri, JJ Benschop, FCP Holstege, NJ Krogan, ... PLoS genetics 9 (8), e1003758, 2013 | 25 | 2013 |
Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism KA Orlando, AK Douglas, A Abudu, Y Wang, B Tessier-Cloutier, W Su, ... Elife 9, e59073, 2020 | 23 | 2020 |
Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase–deficient ovarian cancer, including small-cell carcinoma of the ovary, hypercalcemic … JX Ji, DR Cochrane, B Tessier-Cloutier, SY Chen, G Ho, KV Pathak, ... Clinical Cancer Research 26 (16), 4402-4413, 2020 | 22 | 2020 |