Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches M Chen, JL Manley Nature reviews Molecular cell biology 10 (11), 741-754, 2009 | 1463 | 2009 |
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer CJ David, M Chen, M Assanah, P Canoll, JL Manley Nature 463 (7279), 364-368, 2010 | 1213 | 2010 |
TGF-β tumor suppression through a lethal EMT CJ David, YH Huang, M Chen, J Su, Y Zou, N Bardeesy, ... Cell 164 (5), 1015-1030, 2016 | 579 | 2016 |
Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA M Chen, J Zhang, JL Manley Cancer research 70 (22), 8977-8980, 2010 | 240 | 2010 |
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins M Chen, CJ David, JL Manley Nature structural & molecular biology 19 (3), 346-354, 2012 | 121 | 2012 |
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator Y Feng, M Chen, JL Manley Nature structural & molecular biology 15 (10), 1040-1048, 2008 | 112 | 2008 |
MLL-AF9–and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C N Zhu, M Chen, R Eng, J DeJong, AU Sinha, NF Rahnamay, R Koche, ... The Journal of clinical investigation 126 (3), 997-1011, 2016 | 103 | 2016 |
JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors M Chen, N Zhu, X Liu, B Laurent, Z Tang, R Eng, Y Shi, SA Armstrong, ... Genes & development 29 (20), 2123-2139, 2015 | 93 | 2015 |
Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer Y Li, Y He, J Peng, Z Su, Z Li, B Zhang, J Ma, M Zhuo, D Zou, X Liu, X Liu, ... Nature Cancer 2 (1), 49-65, 2021 | 59 | 2021 |
Tumor-derived Jagged1 promotes cancer progression through immune evasion J Meng, Y Jiang, S Zhao, Y Tao, T Zhang, X Wang, Y Zhang, K Sun, ... Cell Reports 38 (10), 2022 | 20 | 2022 |
The PAF1 complex promotes 3′ processing of pervasive transcripts X Liu, Z Guo, J Han, B Peng, B Zhang, H Li, X Hu, CJ David, M Chen Cell reports 38 (11), 2022 | 19 | 2022 |
Tumor metabolism: hnRNP proteins get in on the act M Chen, CJ David, JL Manley Cell Cycle 9 (10), 1863-1864, 2010 | 16 | 2010 |
p300 通过 homeobox 结构域增强 Nanog 的转录激活活性 郭允倩, 陈默, 马天骅, 裴端卿 中国生物工程杂志 29 (10), 1-5, 2009 | 7 | 2009 |
LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t (8; 21) AML Q Chen, MA Cevher, Q Jiang, S Wang, X Sun, RG Roeder, M Chen Proceedings of the National Academy of Sciences 119 (42), e2213718119, 2022 | 4 | 2022 |
Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression X Liu, X Liu, Y Du, D Zou, C Tian, Y Li, X Lan, CJ David, Q Sun, M Chen Cell Reports 42 (8), 2023 | 1 | 2023 |
CircR-looping the leukemic translocations: The cause of MLL translocations explained M Chen Molecular Cell 83 (13), 2164-2166, 2023 | 1 | 2023 |
Defining pervasive transcription units using chromatin RNA-sequencing data Z Guo, X Liu, M Chen STAR protocols 3 (2), 101442, 2022 | 1 | 2022 |