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Jianbin Ruan
Jianbin Ruan
University of Connecticut Health Center
Verified email at uchc.edu
Title
Cited by
Cited by
Year
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
X Liu, Z Zhang, J Ruan, Y Pan, VG Magupalli, H Wu, J Lieberman
Nature 535 (7610), 153-158, 2016
25152016
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ...
Cell 156 (6), 1193-1206, 2014
12262014
The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages
CL Evavold, J Ruan, Y Tan, S Xia, H Wu, JC Kagan
Immunity 48 (1), 35-44. e6, 2018
9602018
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao, J Ruan, X Luo, X Lou, ...
Nature immunology 21 (7), 736-745, 2020
6292020
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
I Zanoni, Y Tan, M Di Gioia, A Broggi, J Ruan, J Shi, CA Donado, F Shao, ...
Science 352 (6290), 1232-1236, 2016
4972016
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
L Zhang, S Chen, J Ruan, J Wu, AB Tong, Q Yin, Y Li, L David, A Lu, ...
Science 350 (6259), 404-409, 2015
4062015
Gasdermin D pore structure reveals preferential release of mature interleukin-1
S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong, SM Vora, L Wang, ...
Nature 593 (7860), 607-611, 2021
3392021
Cryo-EM structure of the gasdermin A3 membrane pore
J Ruan, S Xia, X Liu, J Lieberman, H Wu
Nature 557 (7703), 62-67, 2018
3312018
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
C Bian, C Xu, J Ruan, KK Lee, TL Burke, W Tempel, D Barsyte, J Li, M Wu, ...
The EMBO journal 30 (14), 2829-2842, 2011
2852011
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis
Y Yao, T Sun, S Huang, S Dou, L Lin, J Chen, J Ruan, C Mao, F Yu, ...
Science translational medicine 4 (130), 130ra48-130ra48, 2012
2062012
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
FI Schmidt, A Lu, JW Chen, J Ruan, C Tang, H Wu, HL Ploegh
Journal of Experimental Medicine 213 (5), 771-790, 2016
1522016
Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2
A Annibaldi, SW John, TV Berghe, KN Swatek, J Ruan, G Liccardi, ...
Molecular cell 69 (4), 566-580. e5, 2018
1202018
Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1
Y Li, TM Fu, A Lu, K Witt, J Ruan, C Shen, H Wu
Proceedings of the National Academy of Sciences 115 (43), 10845-10852, 2018
1162018
SERPINB1-mediated checkpoint of inflammatory caspase activation
YJ Choi, S Kim, Y Choi, TB Nielsen, J Yan, A Lu, J Ruan, HR Lee, H Wu, ...
Nature immunology 20 (3), 276-287, 2019
972019
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
A Lu, Y Li, Q Yin, J Ruan, X Yu, E Egelman, H Wu
Cell discovery 1 (1), 1-14, 2015
922015
Molecular mechanism for NLRP6 inflammasome assembly and activation
C Shen, A Lu, WJ Xie, J Ruan, R Negro, EH Egelman, TM Fu, H Wu
Proceedings of the National Academy of Sciences 116 (6), 2052-2057, 2019
892019
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin
AJ Russo, SO Vasudevan, SP Méndez-Huergo, P Kumari, A Menoret, ...
Nature immunology 22 (2), 154-165, 2021
872021
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
L Robert Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, ...
Nature communications 12 (1), 189, 2021
532021
Structural insight of gasdermin family driving pyroptotic cell death
J Ruan
Structural Immunology, 189-205, 2019
512019
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9
J Li, Z Li, J Ruan, C Xu, Y Tong, PW Pan, W Tempel, L Crombet, J Min, ...
PloS one 6 (10), e25104, 2011
472011
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