Colm J. Ryan
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Hierarchical Modularity and the Evolution of Genetic Interactomes across Species
CJ Ryan, A Roguev, K Patrick, J Xu, H Jahari, Z Tong, P Beltrao, M Shales, ...
Molecular Cell 46 (5), 691-704, 2012
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
CT Williamson, R Miller, HN Pemberton, SE Jones, J Campbell, A Konde, ...
Nature communications 7, 13837, 2016
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
J Campbell, CJ Ryan, R Brough, I Bajrami, HN Pemberton, IY Chong, ...
Cell Reports 14 (10), 2490-2501, 2016
High-resolution network biology: connecting sequence with function
CJ Ryan, P Cimermančič, ZA Szpiech, A Sali, RD Hernandez, NJ Krogan
Nature Reviews Genetics 14 (12), 865-879, 2013
The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing
EA Moehle, CJ Ryan, NJ Krogan, TL Kress, C Guthrie
PLOS Genetics 8 (11), e1003101, 2012
Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
MG Oser, R Fonseca, AA Chakraborty, R Brough, A Spektor, RB Jennings, ...
Cancer discovery 9 (2), 230-247, 2019
Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation
JE Haber, H Braberg, Q Wu, R Alexander, J Haase, C Ryan, ...
Cell reports 3 (6), 2168-2178, 2013
E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
I Bajrami, R Marlow, M van de Ven, R Brough, HN Pemberton, J Frankum, ...
Cancer discovery 8 (4), 498-515, 2018
Key Functional Regions in the Histone Variant H2A. Z C-Terminal Docking Domain
AY Wang, MJ Aristizabal, C Ryan, NJ Krogan, MS Kobor
Molecular and Cellular Biology 31 (18), 3871, 2011
Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae
JI Kliegman, D Fiedler, CJ Ryan, YF Xu, X Su, D Thomas, MC Caccese, ...
Cell reports 5 (6), 1725-1736, 2013
Synthetic lethality and cancer–penetrance as the major barrier
CJ Ryan, I Bajrami, CJ Lord
Trends in cancer 4 (10), 671-683, 2018
Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast.
KL Patrick, CJ Ryan, J Xu, JJ Lipp, KE Nissen, A Roguev, M Shales, ...
PLoS genetics 11 (3), e1005074-e1005074, 2015
All or nothing: protein complexes flip essentiality between distantly related eukaryotes
CJ Ryan, NJ Krogan, P Cunningham, G Cagney
Genome Biology and Evolution, 2013
Missing value imputation for epistatic MAPs
C Ryan, D Greene, G Cagney, P Cunningham
BMC bioinformatics 11 (1), 197, 2010
A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events
CJ Ryan, S Kennedy, I Bajrami, D Matallanas, CJ Lord
Cell systems 5 (4), 399-409. e5, 2017
DAISY: Picking Synthetic Lethals from Cancer Genomes
CJ Ryan, CJ Lord, A Ashworth
Cancer cell 26 (3), 306-308, 2014
The histone variant H2A. Z promotes splicing of weak introns
KE Nissen, CM Homer, CJ Ryan, M Shales, NJ Krogan, KL Patrick, ...
Genes & Development 31 (7), 688-701, 2017
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
R Brough, A Gulati, S Haider, R Kumar, J Campbell, E Knudsen, SJ Pettitt, ...
Oncogene, 1, 2018
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
B De Kegel, CJ Ryan
PLoS genetics 15 (10), 2019
Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function
HS Kim, R Mukhopadhyay, SB Rothbart, AC Silva, V Vanoosthuyse, ...
Cell reports 6 (5), 892-905, 2014
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Articles 1–20