| The epichaperome is an integrated chaperome network that facilitates tumour survival A Rodina, T Wang, P Yan, EDG Gomes, MPS Dunphy, N Pillarsetty, ... Nature 538 (7625), 397-401, 2016 | 247 | 2016 |
| Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin Y Li, D Zhang, W Jin, C Shao, P Yan, C Xu, H Sheng, Y Liu, J Yu, Y Xie, ... The Journal of clinical investigation 116 (2), 506-511, 2006 | 226 | 2006 |
| Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 PD Patel, P Yan, PM Seidler, HJ Patel, W Sun, C Yang, NS Que, ... Nature chemical biology 9 (11), 677-684, 2013 | 209 | 2013 |
| Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK) G Qing, P Yan, G Xiao Cell research 16 (11), 895-901, 2006 | 175 | 2006 |
| Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation G Qing, P Yan, Z Qu, H Liu, G Xiao Cell research 17 (6), 520-530, 2007 | 136 | 2007 |
| Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein A Rodina, PD Patel, Y Kang, Y Patel, I Baaklini, MJH Wong, T Taldone, ... Chemistry & biology 20 (12), 1469-1480, 2013 | 105 | 2013 |
| PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation P Yan, J Fu, Z Qu, S Li, T Tanaka, MJ Grusby, G Xiao Blood, The Journal of the American Society of Hematology 113 (18), 4370-4380, 2009 | 81 | 2009 |
| The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis J Fu, Z Qu, P Yan, C Ishikawa, RI Aqeilan, AB Rabson, G Xiao Blood, The Journal of the American Society of Hematology 117 (5), 1652-1661, 2011 | 76 | 2011 |
| Effect of μ-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population D Zhang, C Shao, M Shao, P Yan, Y Wang, Y Liu, W Liu, T Lin, Y Xie, ... Biological psychiatry 61 (11), 1244-1251, 2007 | 73 | 2007 |
| Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer Z Qu, J Fu, P Yan, J Hu, SY Cheng, G Xiao Journal of biological chemistry 285 (16), 11786-11792, 2010 | 69 | 2010 |
| The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue‐elicited heroin craving in Chinese YF Li, CH Shao, D Zhang, M Zhao, L Lin, P Yan, Y Xie, K Jiang, L Jin American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141 …, 2006 | 69 | 2006 |
| Structure–activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94 HJ Patel, PD Patel, SO Ochiana, P Yan, W Sun, MR Patel, SK Shah, ... Journal of medicinal chemistry 58 (9), 3922-3943, 2015 | 58 | 2015 |
| DNA methylation–dependent repression of PDZ-LIM domain–containing protein 2 in colon cancer and its role as a potential therapeutic target Z Qu, P Yan, J Fu, J Jiang, MJ Grusby, TE Smithgall, G Xiao Cancer research 70 (5), 1766-1772, 2010 | 56 | 2010 |
| The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction MC Inda, S Joshi, T Wang, A Bolaender, S Gandu, J Koren III, AY Che, ... Nature Communications 11 (1), 319, 2020 | 50 | 2020 |
| Paradigms for precision medicine in epichaperome cancer therapy N Pillarsetty, K Jhaveri, T Taldone, E Caldas-Lopes, B Punzalan, S Joshi, ... Cancer Cell 36 (5), 559-573. e7, 2019 | 45 | 2019 |
| Targeting autophagic regulation of NF-kappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions P Yan, G Qing, Z Qu, CC Wu, A Rabson, G Xiao Autophagy 3 (6), 600-603, 2007 | 42 | 2007 |
| Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis J Fu, P Yan, S Li, Z Qu, G Xiao Oncogene 29 (49), 6499-6507, 2010 | 40 | 2010 |
| Molecular stressors engender protein connectivity dysfunction through aberrant N-glycosylation of a chaperone P Yan, HJ Patel, S Sharma, A Corben, T Wang, P Panchal, C Yang, ... Cell reports 31 (13), 2020 | 38 | 2020 |
| A chemical biology approach to the chaperome in cancer—HSP90 and beyond T Taldone, T Wang, A Rodina, NVK Pillarsetty, CS Digwal, S Sharma, ... Cold Spring Harbor perspectives in biology 12 (4), a034116, 2020 | 35 | 2020 |
| Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance F Sun, L Li, P Yan, J Zhou, SD Shapiro, G Xiao, Z Qu Nature communications 10 (1), 5324, 2019 | 32 | 2019 |
Hardik J. Patel, Ph.D., R.Ph.Research Scholar, Memorial Sloan-Kettering Cancer CenterVerified email at mskcc.org
