Lukasz Bugaj
Lukasz Bugaj
Assistant Professor of Bioengineering, University of Pennsylvania
Verified email at seas.upenn.edu - Homepage
Title
Cited by
Cited by
Year
Optogenetic protein clustering and signaling activation in mammalian cells
LJ Bugaj, AT Choksi, CK Mesuda, RS Kane, DV Schaffer
Nature methods 10 (3), 249-252, 2013
3132013
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
JH Kim, LJ Bugaj, YJ Oh, TJ Bivalacqua, S Ryoo, KG Soucy, L Santhanam, ...
Journal of applied physiology 107 (4), 1249-1257, 2009
2492009
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
H Yousef, MJ Conboy, A Morgenthaler, C Schlesinger, L Bugaj, P Paliwal, ...
Oncotarget 6 (14), 11959, 2015
852015
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
J Steppan, S Ryoo, KH Schuleri, C Gregg, RK Hasan, AR White, LJ Bugaj, ...
Proceedings of the National Academy of Sciences 103 (12), 4759-4764, 2006
852006
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ...
Science 361 (6405), 2018
742018
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering
LJ Bugaj, DP Spelke, CK Mesuda, M Varedi, RS Kane, DV Schaffer
Nature communications 6 (1), 1-10, 2015
682015
Age‐associated increase in BMP signaling inhibits hippocampal neurogenesis
H Yousef, A Morgenthaler, C Schlesinger, L Bugaj, IM Conboy, ...
Stem cells 33 (5), 1577-1588, 2015
622015
Modular engineering of cellular signaling proteins and networks
RM Gordley, LJ Bugaj, WA Lim
Current opinion in structural biology 39, 106-114, 2016
502016
Interrogating cellular perception and decision making with optogenetic tools
LJ Bugaj, GP O’Donoghue, WA Lim
Journal of Cell Biology 216 (1), 25-28, 2017
302017
Light-inducible activation of target mRNA translation in mammalian cells
J Cao, M Arha, C Sudrik, LJ Bugaj, DV Schaffer, RS Kane
Chemical Communications 49 (75), 8338-8340, 2013
302013
High-throughput multicolor optogenetics in microwell plates
LJ Bugaj, WA Lim
Nature protocols 14 (7), 2205-2228, 2019
172019
Bringing next-generation therapeutics to the clinic through synthetic biology
LJ Bugaj, DV Schaffer
Current opinion in chemical biology 16 (3-4), 355-361, 2012
172012
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway
AR White, S Ryoo, L Bugaj, DO Attarzadeh, S Thiyagarajan, K Chen, ...
European journal of applied physiology 110 (2), 395-404, 2010
152010
Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics
SY Chen, LC Osimiri, M Chevalier, LJ Bugaj, TH Nguyen, RA Greenstein, ...
Cell systems 11 (4), 336-353. e24, 2020
142020
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
M Khan, J Steppan, K Schuleri, S Ryoo, E Tuday, L Bugaj, L Santhanam, ...
European journal of applied physiology 112 (8), 2933-2941, 2012
122012
Reverse and Forward Engineering Multicellular Structures with Optogenetics
TR Mumford, L Roth, LJ Bugaj
Current Opinion in Biomedical Engineering, 100250, 2020
42020
Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation
EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, BY Chow
Photochemical & Photobiological Sciences 19 (3), 353-361, 2020
42020
T cells selectively filter oscillatory signals on the minutes timescale
GP O’Donoghue, LJ Bugaj, W Anderson, KG Daniels, DJ Rawlings, ...
Proceedings of the National Academy of Sciences 118 (9), 2021
22021
β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells
AB Rosenbloom, M Tarczyński, N Lam, RS Kane, LJ Bugaj, DV Schaffer
Proceedings of the National Academy of Sciences 117 (46), 28828-28837, 2020
12020
Vertebrate cells differentially interpret ciliary and extraciliary cAMP
ME Truong, S Bilekova, SP Choksi, W Li, LJ Bugaj, K Xu, JF Reiter
Cell, 2021
2021
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Articles 1–20