Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells M Micco, GW Collie, AG Dale, SA Ohnmacht, I Pazitna, M Gunaratnam, ... Journal of medicinal chemistry 56 (7), 2959-2974, 2013 | 192 | 2013 |
Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule SJ Welsh, AG Dale, CM Lombardo, H Valentine, M de La Fuente, ... Scientific reports 3 (1), 2799, 2013 | 43 | 2013 |
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines CM Lombardo, SJ Welsh, SJ Strauss, AG Dale, AK Todd, R Nanjunda, ... Bioorganic & medicinal chemistry letters 22 (18), 5984-5988, 2012 | 39 | 2012 |
Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase AG Dale, J Hinds, J Mann, PW Taylor, S Neidle Biochemistry 51 (29), 5860-5871, 2012 | 31 | 2012 |
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership J Mann, PW Taylor, CR Dorgan, PD Johnson, FX Wilson, R Vickers, ... Medchemcomm 6 (8), 1420-1426, 2015 | 30 | 2015 |
The ectopically parting cells 1-2 (epc1-2) mutant exhibits an exaggerated response to abscisic acid L Bown, S Kusaba, F Goubet, L Codrai, AG Dale, Z Zhang, X Yu, K Morris, ... Journal of experimental botany 58 (7), 1813-1823, 2007 | 26 | 2007 |
Increased toxin expression in a Clostridium difficile mfd mutant SE Willing, EJ Richards, L Sempere, AG Dale, SM Cutting, ... BMC microbiology 15, 1-10, 2015 | 24 | 2015 |
The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds AG Dale, A Porcu, J Mann, S Neidle Medicinal Chemistry Research 31 (7), 1176-1191, 2022 | 2 | 2022 |
Diimide compounds S Neidle, SA Ohnmacht, M Gunaratnam, AG Dale, M Micco, GW Collie US Patent 9,493,460, 2016 | | 2016 |
Elucidating the molecular target of symmetric bis-benzimidazoles AG Dale PQDT-Global, 2011 | | 2011 |
Broadening the field of opportunity for medicinal chemists www. rsc. org/medchemcomm J Mann, PW Taylor, CR Dorgan, PD Johnson, FX Wilson, R Vickers, ... | | |