Executive summary: heart disease and stroke statistics—2014 update: a report from the American Heart Association AS Go, D Mozaffarian, VL Roger, EJ Benjamin, JD Berry, MJ Blaha, S Dai, ... Circulation 129 (3), 399-410, 2014 | 24554* | 2014 |
Executive summary: heart disease and stroke statistics—2015 update: a report from the American Heart Association D Mozaffarian, EJ Benjamin, AS Go, DK Arnett, MJ Blaha, M Cushman, ... Circulation 131 (4), 434-441, 2015 | 15619 | 2015 |
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts KS Vimaleswaran, DJ Berry, C Lu, E Tikkanen, S Pilz, LT Hiraki, ... PLoS Med 10 (2), e1001383, 2013 | 857 | 2013 |
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium The Lancet 379 (9822), 1214-1224, 2012 | 723 | 2012 |
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people MR Nelson, D Wegmann, MG Ehm, D Kessner, PS Jean, C Verzilli, ... Science 337 (6090), 100-104, 2012 | 687 | 2012 |
The support of human genetic evidence for approved drug indications MR Nelson, H Tipney, JL Painter, J Shen, P Nicoletti, Y Shen, A Floratos, ... Nature genetics 47 (8), 856-860, 2015 | 617 | 2015 |
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease N Hubner, CA Wallace, H Zimdahl, E Petretto, H Schulz, F Maciver, ... Nature genetics 37 (3), 243-253, 2005 | 573 | 2005 |
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data MV Holmes, CE Dale, L Zuccolo, RJ Silverwood, Y Guo, Z Ye, ... Bmj 349, g4164, 2014 | 540 | 2014 |
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials DI Swerdlow, D Preiss, KB Kuchenbaecker, MV Holmes, JEL Engmann, ... The Lancet 385 (9965), 351-361, 2015 | 506 | 2015 |
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study PJ Talmud, S Shah, R Whittall, M Futema, P Howard, JA Cooper, ... The Lancet 381 (9874), 1293-1301, 2013 | 457 | 2013 |
Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies CJ Hoggart, JC Whittaker, M De Iorio, DJ Balding PLoS Genet 4 (7), e1000130, 2008 | 374 | 2008 |
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus AI Russell, DS Cunninghame Graham, C Shepherd, CA Roberton, ... Human molecular genetics 13 (1), 137-147, 2004 | 344 | 2004 |
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials MV Holmes, P Newcombe, JA Hubacek, R Sofat, SL Ricketts, J Cooper, ... The Lancet 378 (9791), 584-594, 2011 | 325 | 2011 |
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study KS Vimaleswaran, A Cavadino, DJ Berry, R Jorde, AK Dieffenbach, C Lu, ... The lancet Diabetes & endocrinology 2 (9), 719-729, 2014 | 312 | 2014 |
Marker-assisted selection using ridge regression JC Whittaker, R Thompson, MC Denham Genetics Research 75 (2), 249-252, 2000 | 309 | 2000 |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci FW Asselbergs, Y Guo, EPA Van Iperen, S Sivapalaratnam, V Tragante, ... The American Journal of Human Genetics 91 (5), 823-838, 2012 | 268 | 2012 |
HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer CF Spraggs, LR Budde, LP Briley, N Bing, CJ Cox, KS King, JC Whittaker, ... Journal of Clinical Oncology 29 (6), 667-673, 2011 | 246 | 2011 |
Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy SWC Van Mil, A Milona, PH Dixon, R Mullenbach, VL Geenes, ... Gastroenterology 133 (2), 507-516, 2007 | 242 | 2007 |
Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia MC Clarke, A Tanskanen, M Huttunen, JC Whittaker, M Cannon American Journal of Psychiatry 166 (9), 1025-1030, 2009 | 239 | 2009 |
Genome-wide association study of major recurrent depression in the UK population CM Lewis, MY Ng, AW Butler, S Cohen-Woods, R Uher, K Pirlo, ... American Journal of Psychiatry 167 (8), 949-957, 2010 | 235 | 2010 |