| Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation MA Blount, A Beasley, R Zoraghi, KR Sekhar, EP Bessay, SH Francis, ... Molecular Pharmacology 66 (1), 144-152, 2004 | 232 | 2004 |
| Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins R Zoraghi, JD Corbin, SH Francis Molecular pharmacology 65 (2), 267-278, 2004 | 200 | 2004 |
| Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development H Wang, Y Liu, Q Huai, J Cai, R Zoraghi, SH Francis, JD Corbin, ... Journal of Biological Chemistry 281 (30), 21469-21479, 2006 | 177 | 2006 |
| Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities R Zoraghi, L Worrall, RH See, W Strangman, WL Popplewell, H Gong, ... Journal of Biological Chemistry 286 (52), 44716-44725, 2011 | 149 | 2011 |
| Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation R Zoraghi, EP Bessay, JD Corbin, SH Francis Journal of Biological Chemistry 280 (12), 12051-12063, 2005 | 145 | 2005 |
| The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei R Zoraghi, T Seebeck Proceedings of the National Academy of Sciences 99 (7), 4343-4348, 2002 | 85 | 2002 |
| High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients JL Weeks, R Zoraghi, A Beasley, KR Sekhar, SH Francis, JD Corbin International journal of impotence research 17 (1), 5-9, 2005 | 81 | 2005 |
| Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters SH Francis, MA Blount, R Zoraghi, JD Corbin Front Biosci 10 (1-3), 2097, 2005 | 77 | 2005 |
| Mapping the Protein Interaction Network in Methicillin-Resistant Staphylococcus aureus A Cherkasov, M Hsing, R Zoraghi, LJ Foster, RH See, N Stoynov, J Jiang, ... Journal of proteome research 10 (3), 1139-1150, 2011 | 76 | 2011 |
| Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity R Zoraghi, JD Corbin, SH Francis Journal of biological chemistry 281 (9), 5553-5558, 2006 | 68 | 2006 |
| Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity R Zoraghi, JD Corbin, SH Francis Journal of biological chemistry 281 (9), 5553-5558, 2006 | 68 | 2006 |
| Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus R Zoraghi, RH See, H Gong, T Lian, R Swayze, BB Finlay, RC Brunham, ... Biochemistry 49 (35), 7733-7747, 2010 | 63 | 2010 |
| cAMP signalling in Trypanosoma brucei T Seebeck, KW Gong, S Kunz, R Schaub, T Shalaby, R Zoraghi International journal for parasitology 31 (5-6), 491-498, 2001 | 63 | 2001 |
| Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target R Zoraghi, RH See, P Axerio-Cilies, NS Kumar, H Gong, A Moreau, ... Antimicrobial agents and chemotherapy 55 (5), 2042-2053, 2011 | 61 | 2011 |
| Protein interaction networks as starting points to identify novel antimicrobial drug targets R Zoraghi, NE Reiner Current opinion in microbiology 16 (5), 566-572, 2013 | 54 | 2013 |
| Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature S Kunz, JA Beavo, MA D'angelo, MM Flawia, SH Francis, A Johner, ... Elsevier Science, 2006 | 51 | 2006 |
| Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei R Zoraghi, S Kunz, K Gong, T Seebeck Journal of Biological Chemistry 276 (15), 11559-11566, 2001 | 47 | 2001 |
| A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization MA Blount, R Zoraghi, H Ke, EP Bessay, JD Corbin, SH Francis Molecular pharmacology 70 (5), 1822-1831, 2006 | 43 | 2006 |
| Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase CGL Veale, R Zoraghi, RM Young, JP Morrison, M Pretheeban, KA Lobb, ... Journal of natural products 78 (3), 355-362, 2015 | 42 | 2015 |
| Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections NS Kumar, EM Dullaghan, BB Finlay, H Gong, NE Reiner, JJP Selvam, ... Bioorganic & medicinal chemistry 22 (5), 1708-1725, 2014 | 41 | 2014 |
