Allan Okey
Allan Okey
Professor of Pharmacology & Toxicology, University of Toronto
Verified email at
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Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
DW Nebert, TP Dalton, AB Okey, FJ Gonzalez
Journal of biological chemistry 279 (23), 23847-23850, 2004
Enzyme induction in the cytochrome P-450 system
AB Okey
Pharmacology & therapeutics 45 (2), 241-298, 1990
The Ah receptor: mediator of the toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds
AB Okey, DS Riddick, PA Harper
Toxicology letters 70 (1), 1-22, 1994
Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation
AB Okey, O AB, M ME
Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
N Tijet, PC Boutros, ID Moffat, AB Okey, J Tuomisto, R Pohjanvirta
Molecular pharmacology 69 (1), 140-153, 2006
Genetic mechanisms controlling the induction of polysubstrate monooxygenase (P-450) activities
DW Nebert, HJ Eisen, M Negishi, MA Lang, LM Hjelmeland, AB Okey
Annual review of pharmacology and toxicology 21 (1), 431-462, 1981
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene-or mixed-type inducers to cytosolic Ah receptor
S Bandiera, S Safe, AB Okey
Chemico-biological interactions 39 (3), 259-277, 1982
An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI
AB Okey
Toxicological Sciences 98 (1), 5-38, 2007
Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation
PH Jellinck, P Gekforkert, DS Riddick, AB Okey, JJ Michnovicz, ...
Biochemical pharmacology 45 (5), 1129-1136, 1993
Molecular biology of the aromatic hydrocarbon (dioxin) receptor
AB Okey, DS Riddick, PA Harper
Trends in pharmacological sciences 15 (7), 226-232, 1994
Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines
AB Okey, O AB, M ME, N DW
Structure and function of the Ah receptor for 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic …
MS Denison, LM Vella, AB Okey
Journal of Biological Chemistry 261 (9), 3987-3995, 1986
Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.
AB Okey, LM Vella, PA Harper
Molecular pharmacology 35 (6), 823-830, 1989
Polymorphisms in the human AH receptor
PA Harper, JMY Wong, MSM Lam, AB Okey
Chemico-biological interactions 141 (1-2), 161-187, 2002
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo (a) pyrene
DK Manchester, SK Gordon, CL Golas, EA Roberts, AB Okey
Cancer research 47 (18), 4861-4868, 1987
Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-resistant rat …
R Pohjanvirta, JMY Wong, W Li, PA Harper, J Tuomisto, AB Okey
Molecular pharmacology 54 (1), 86-93, 1998
Dietary phytoestrogen intake is associated with reduced colorectal cancer risk
M Cotterchio, BA Boucher, M Manno, S Gallinger, A Okey, P Harper
The Journal of nutrition 136 (12), 3046-3053, 2006
Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor
PA Harper, DS Riddick, AB Okey
Biochemical pharmacology 72 (3), 267-279, 2006
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2, 3, 7, 8 …
W Li, PA Harper, BK Tang, AB Okey
Biochemical pharmacology 56 (5), 599-612, 1998
Unsupervised pattern recognition: an introduction to the whys and wherefores of clustering microarray data
PC Boutros, AB Okey
Briefings in bioinformatics 6 (4), 331-343, 2005
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