Jean-Philippe Gratton
Jean-Philippe Gratton
Pharmacology and Physiology, Université de Montréal
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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
D Fulton, JP Gratton, TJ McCabe, J Fontana, Y Fujio, K Walsh, TF Franke, ...
Nature 399 (6736), 597-601, 1999
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
M Bucci, JP Gratton, RD Rudic, L Acevedo, F Roviezzo, G Cirino, ...
Nature medicine 6 (12), 1362-1367, 2000
Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?
D Fulton, JP Gratton, WC Sessa
Journal of Pharmacology and Experimental Therapeutics 299 (3), 818-824, 2001
Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: evidence that hsp90 facilitates calmodulin stimulated displacement of …
JP Gratton, J Fontana, DS O'Connor, G Garcı́a-Cardeña, TJ McCabe, ...
Journal of Biological Chemistry 275 (29), 22268-22272, 2000
Caveolae and caveolins in the cardiovascular system
JP Gratton, P Bernatchez, WC Sessa
Circulation research 94 (11), 1408-1417, 2004
Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
JP Gratton, M Morales-Ruiz, Y Kureishi, D Fulton, K Walsh, WC Sessa
Journal of Biological Chemistry 276 (32), 30359-30365, 2001
Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Giprotein/phosphoinositide 3-kinase pathway in endothelial cells
M Morales-Ruiz, MJ Lee, S Zöllner, JP Gratton, R Scotland, I Shiojima, ...
Journal of Biological Chemistry 276 (22), 19672-19677, 2001
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice
JP Gratton, MI Lin, J Yu, ED Weiss, ZL Jiang, TA Fairchild, Y Iwakiri, ...
Cancer cell 4 (1), 31-39, 2003
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme
D Fulton, J Fontana, G Sowa, JP Gratton, M Lin, KX Li, B Michell, ...
Journal of Biological Chemistry 277 (6), 4277-4284, 2002
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo
JP Gratton, J Yu, JW Griffith, RW Babbitt, RS Scotland, R Hickey, ...
Nature medicine 9 (3), 357-362, 2003
Acidic hydrolysis as a mechanism for the cleavage of the Glu298→ Asp variant of human endothelial nitric-oxide synthase
TA Fairchild, D Fulton, JT Fontana, JP Gratton, TJ McCabe, WC Sessa
Journal of Biological Chemistry 276 (28), 26674-26679, 2001
S-Nitrosylation of β-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability
S Thibeault, Y Rautureau, M Oubaha, D Faubert, BC Wilkes, C Delisle, ...
Molecular cell 39 (3), 468-476, 2010
Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase
M Duval, F Le Bœuf, J Huot, JP Gratton
Molecular biology of the cell 18 (11), 4659-4668, 2007
Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination: consequences on nitric oxide production from endothelial cells
M Duval, S Bédard-Goulet, C Delisle, JP Gratton
Journal of Biological Chemistry 278 (22), 20091-20097, 2003
The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane* 210
HE Karpen, JT Bukowski, T Hughes, JP Gratton, WC Sessa, MR Gailani
Journal of Biological Chemistry 276 (22), 19503-19511, 2001
Angiopoietin‐1 activates both anti‐and proapoptotic mitogen‐activated protein kinases
R Harfouche, JP Gratton, GD Yancopoulos, M Noseda, A Karsan, ...
The FASEB journal 17 (11), 1-25, 2003
The receptor tyrosine kinase AXL is required at multiple steps of the metastatic cascade during HER2-positive breast cancer progression
MA Goyette, S Duhamel, L Aubert, A Pelletier, P Savage, MP Thibault, ...
Cell reports 23 (5), 1476-1490, 2018
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function
PN Bernatchez, L Acevedo, C Fernandez-Hernando, T Murata, ...
Journal of Biological Chemistry 282 (42), 30745-30753, 2007
Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion
RS Scotland, M Morales-Ruiz, Y Chen, J Yu, RD Rudic, D Fulton, ...
Circulation research 90 (8), 904-910, 2002
Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension
Y Iwakiri, MH Tsai, TJ McCabe, JP Gratton, D Fulton, RJ Groszmann, ...
American Journal of Physiology-Heart and Circulatory Physiology 282 (6 …, 2002
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