| Substituted 4-(thiazol-5-yl)-2-(phenylamino) pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure–activity relationship, and anticancer … H Shao, S Shi, S Huang, AJ Hole, AY Abbas, S Baumli, X Liu, F Lam, ... Journal of medicinal chemistry 56 (3), 640-659, 2013 | 134 | 2013 |
| Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice B Caballero, M Bourdenx, E Luengo, A Diaz, PD Sohn, XU Chen, C Wang, ... Nature Communications 12 (1), 2238, 2021 | 121 | 2021 |
| Targeting the Hsp40/Hsp70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer MA Moses, YS Kim, GM Rivera-Marquez, N Oshima, MJ Watson, ... Cancer research 78 (14), 4022-4035, 2018 | 119 | 2018 |
| Synthesis and biological evaluation of imidazo [4, 5-b] pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents PM Lukasik, S Elabar, F Lam, H Shao, X Liu, AY Abbas, S Wang European journal of medicinal chemistry 57, 311-322, 2012 | 106 | 2012 |
| Zika virus dependence on host Hsp70 provides a protective strategy against infection and disease S Taguwa, MT Yeh, TK Rainbolt, A Nayak, H Shao, JE Gestwicki, ... Cell reports 26 (4), 906-920. e3, 2019 | 101 | 2019 |
| A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine E Walsby, G Pratt, H Shao, AY Abbas, PM Fischer, TD Bradshaw, ... Oncotarget 5 (2), 375, 2014 | 93 | 2014 |
| Exploration of benzothiazole rhodacyanines as allosteric inhibitors of protein–protein interactions with heat shock protein 70 (Hsp70) H Shao, X Li, MA Moses, LA Gilbert, C Kalyanaraman, ZT Young, ... Journal of medicinal chemistry 61 (14), 6163-6177, 2018 | 87 | 2018 |
| Inhibitors and chemical probes for molecular chaperone networks JE Gestwicki, H Shao Journal of Biological Chemistry 294 (6), 2151-2161, 2019 | 73 | 2019 |
| Adhesion-mediated mechanosignaling forces mitohormesis KM Tharp, R Higuchi-Sanabria, GA Timblin, B Ford, C Garzon-Coral, ... Cell metabolism 33 (7), 1322-1341. e13, 2021 | 72 | 2021 |
| KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice ES Polson, VB Kuchler, C Abbosh, EM Ross, RK Mathew, HA Beard, ... Science translational medicine 10 (454), eaar2718, 2018 | 67 | 2018 |
| Targeting allosteric control mechanisms in heat shock protein 70 (Hsp70) X Li, H Shao, I R Taylor, J E Gestwicki Current topics in medicinal chemistry 16 (25), 2729-2740, 2016 | 62 | 2016 |
| Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 F Lam, AY Abbas, H Shao, T Teo, J Adams, P Li, TD Bradshaw, ... Oncotarget 5 (17), 7691, 2014 | 57 | 2014 |
| Synthesis, structure–activity relationship and biological evaluation of 2, 4, 5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents H Shao, S Shi, DW Foley, F Lam, AY Abbas, X Liu, S Huang, X Jiang, ... European Journal of Medicinal Chemistry 70, 447-455, 2013 | 56 | 2013 |
| Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity AJ Hole, S Baumli, H Shao, S Shi, S Huang, C Pepper, PM Fischer, ... Journal of medicinal chemistry 56 (3), 660-670, 2013 | 55 | 2013 |
| Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor B Eftekharzadeh, VC Banduseela, G Chiesa, P Martínez-Cristóbal, ... Nature communications 10 (1), 3562, 2019 | 52 | 2019 |
| Heat shock protein 70 (Hsp70) suppresses RIP1-dependent apoptotic and necroptotic cascades SR Srinivasan, LC Cesa, X Li, O Julien, M Zhuang, H Shao, J Chung, ... Molecular cancer research 16 (1), 58-68, 2018 | 48 | 2018 |
| X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition LC Cesa, H Shao, SR Srinivasan, E Tse, C Jain, ERP Zuiderweg, ... Journal of Biological Chemistry 293 (7), 2370-2380, 2018 | 47 | 2018 |
| Synthesis and properties of novel organosoluble polyimides derived from bis [3-(4-amino-2-trifluoromethylphenoxy) phenyl] ether F Yang, J Zhao, Y Li, S Zhang, Y Shao, H Shao, T Ma, C Gong European polymer journal 45 (7), 2053-2059, 2009 | 40 | 2009 |
| HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C AA Glazier, N Hafeez, D Mellacheruvu, V Basrur, AI Nesvizhskii, LM Lee, ... JCI insight 3 (11), 2018 | 39 | 2018 |
| Anticancer effects of targeting Hsp70 in tumor stromal cells VL Gabai, JA Yaglom, Y Wang, L Meng, H Shao, G Kim, T Colvin, ... Cancer research 76 (20), 5926-5932, 2016 | 38 | 2016 |
Jason E. GestwickiUniversity of California San FranciscoVerified email at ucsf.edu
