Jochen Weile

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Frederick P (Fritz) RothUniversity of Toronto & Mt Sinai HospitalVerified email at utoronto.ca
Yingzhou WuUniversity of TorontoVerified email at mail.utoronto.ca
Atina CoteLunenfeld Tanenbaum Research InstituteVerified email at lunenfeld.ca
Douglas M FowlerUniversity of WashingtonVerified email at uw.edu
Anil WipatProfessor of Bioinformatics Newcastle UniversityVerified email at ncl.ac.uk
Marc VidalProfessor of Genetics, Harvard Medical SchoolVerified email at dfci.harvard.edu
Alan F RubinWalter and Eliza Hall Institute of Medical Research Verified email at wehi.edu.au
Patrick AloyICREA Research Professor at the Institute for Research in BiomedicineVerified email at irbbarcelona.org
Jan BaumbachUniversity of HamburgVerified email at uni-hamburg.de
Simon CockellSenior Lecturer, School of Biomedical, Nutritional and Sports Sciences, Newcastle UniversityVerified email at newcastle.ac.uk
Phillip LordLecturer in Computing Science, Newcastle UniversityVerified email at newcastle.ac.uk
Darren WilkinsonProfessor of Statistics, Durham University, U.K.Verified email at durham.ac.uk
Carles PonsInstitute for Research in BiomedicineVerified email at irbbarcelona.org
Murat TasanRsearch Fellow, University of TorontoVerified email at utoronto.ca
Fan YangPathology, Stanford UniveristyVerified email at stanford.edu
Matthew PocockComputing Science, Newcastle UniversityVerified email at ncl.ac.uk
Gary BaderProfessor of Molecular Genetics and Computer Science, The Donnelly Centre, University of TorontoVerified email at utoronto.ca
George S KaragiannisDepartment of Microbiology & Immunology, Albert Einstein College of MedicineVerified email at einsteinmed.org
Jennifer HallinanSenior Lecturer, Department of Biological Sciences, Macquarie UniversityVerified email at mq.edu.au
Artem LysenkoRIKENVerified email at postman.riken.jp

Jochen Weile

University of Toronto

Verified email at mail.utoronto.ca

Deep Mutational Scanning Protein-protein interaction Systems biology Computational biology


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A reference map of the human binary protein interactome K Luck, DK Kim, L Lambourne, K Spirohn, BE Begg, W Bian, R Brignall, ... Nature 580 (7803), 402-408, 2020	580	2020
Widespread macromolecular interaction perturbations in human genetic disorders N Sahni, S Yi, M Taipale, JIF Bass, J Coulombe-Huntington, F Yang, ... Cell 161 (3), 647-660, 2015	461	2015
A framework for exhaustively mapping functional missense variants J Weile, S Sun, AG Cote, J Knapp, M Verby, JC Mellor, Y Wu, C Pons, ... Molecular systems biology 13 (12), 957, 2017	129	2017
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics N Yachie, E Petsalaki, JC Mellor, J Weile, Y Jacob, M Verby, SB Ozturk, ... Molecular systems biology 12 (4), 863, 2016	95	2016
MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect D Esposito, J Weile, J Shendure, LM Starita, AT Papenfuss, FP Roth, ... Genome biology 20 (1), 1-11, 2019	92	2019
Multiplexed assays of variant effects contribute to a growing genotype–phenotype atlas J Weile, FP Roth Human genetics 137 (9), 665-678, 2018	84	2018
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation GS Karagiannis, J Weile, GD Bader, J Minta BMC cardiovascular disorders 13 (1), 1-19, 2013	62	2013
KeyPathwayMiner: detecting case-specific biological pathways using expression data N Alcaraz, H Kücük, J Weile, A Wipat, J Baumbach Internet Mathematics 7 (4), 299-313, 2011	54	2011
An integrated dataset for in silico drug discovery SJ Cockell, J Weile, P Lord, C Wipat, D Andriychenko, M Pocock, ... Journal of integrative bioinformatics 7 (3), 15-27, 2010	43	2010
Improved pathogenicity prediction for rare human missense variants Y Wu, H Liu, R Li, S Sun, J Weile, FP Roth The American Journal of Human Genetics 108 (10), 1891-1906, 2021	35	2021
A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase S Sun, J Weile, M Verby, Y Wu, Y Wang, AG Cote, I Fotiadou, ... Genome medicine 12, 1-18, 2020	33	2020
Systematic analysis of bypass suppression of essential genes J van Leeuwen, C Pons, G Tan, JZ Wang, J Hou, J Weile, M Gebbia, ... Molecular systems biology 16 (9), e9828, 2020	25	2020
Mapping DNA damage‐dependent genetic interactions in yeast via party mating and barcode fusion genetics JJ Díaz‐Mejía, A Celaj, JC Mellor, A Coté, A Balint, B Ho, P Bansal, ... Molecular Systems Biology 14 (5), e7985, 2018	25	2018
Shifting landscapes of human MTHFR missense-variant effects J Weile, N Kishore, S Sun, R Maaieh, M Verby, R Li, I Fotiadou, ... The American Journal of Human Genetics 108 (7), 1283-1300, 2021	18	2021
Bayesian integration of networks without gold standards J Weile, K James, J Hallinan, SJ Cockell, P Lord, A Wipat, D Wilkinson Bioinformatics 28 (11), 1495-1500, 2012	17	2012
CoryneCenter–An online resource for the integrated analysis of corynebacterial genome and transcriptome data H Neuweger, J Baumbach, S Albaum, T Bekel, M Dondrup, AT Hüser, ... BMC systems biology 1 (1), 1-12, 2007	15	2007
A web application and service for imputing and visualizing missense variant effect maps Y Wu, J Weile, AG Cote, S Sun, J Knapp, M Verby, FP Roth Bioinformatics 35 (17), 3191-3193, 2019	14	2019
Assessing predictions of fitness effects of missense mutations in SUMO‐conjugating enzyme UBE2I J Zhang, LN Kinch, Q Cong, J Weile, S Sun, AG Cote, FP Roth, NV Grishin Human mutation 38 (9), 1051-1063, 2017	13	2017
Customizable views on semantically integrated networks for systems biology J Weile, M Pocock, SJ Cockell, P Lord, JM Dewar, EM Holstein, ... Bioinformatics 27 (9), 1299-1306, 2011	10	2011
MoRAine-A web server for fast computational transcription factor binding motif re-annotation J Baumbach, T Wittkop, J Weile, T Kohl, S Rahmann Journal of Integrative Bioinformatics 5 (2), 21-34, 2008	10	2008

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