Kirsten Wolthers
Kirsten Wolthers
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Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications
G Luka, A Ahmadi, H Najjaran, E Alocilja, M DeRosa, K Wolthers, A Malki, ...
Sensors 15 (12), 30011-30031, 2015
Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species
JF Stevens, CL Miranda, KR Wolthers, M Schimerlik, ML Deinzer, ...
Journal of Agricultural and Food Chemistry 50 (12), 3435-3443, 2002
Molecular dissection of human methionine synthase reductase: determination of the flavin redox potentials in full-length enzyme and isolated flavin-binding domains
KR Wolthers, J Basran, AW Munro, NS Scrutton
Biochemistry 42 (13), 3911-3920, 2003
Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry
KR Wolthers, X Lou, HS Toogood, D Leys, NS Scrutton
Biochemistry 46 (42), 11833-11844, 2007
Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase
H Olteanu, KR Wolthers, AW Munro, NS Scrutton, R Banerjee
Biochemistry 43 (7), 1988-1997, 2004
Protein interactions in the human methionine synthase− methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
KR Wolthers, NS Scrutton
Biochemistry 46 (23), 6696-6709, 2007
Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia
JP Little, S Simtchouk, SM Schindler, EB Villanueva, NE Gill, DG Walker, ...
Molecular and Cellular Neuroscience 60, 88-96, 2014
Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4, 5-aminomutase
KR Wolthers, C Levy, NS Scrutton, D Leys
Journal of Biological Chemistry 285 (18), 13942-13950, 2010
Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4, 5-aminomutase
KR Wolthers, SEJ Rigby, NS Scrutton
Journal of Biological Chemistry 283 (50), 34615-34625, 2008
Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex
KR Wolthers, NS Scrutton
The FEBS Journal 276 (7), 1942-1951, 2009
Electron transfer in human methionine synthase reductase studied by stopped-flow spectrophotometry
KR Wolthers, NS Scrutton
Biochemistry 43 (2), 490-500, 2004
Crystal structure and solution characterization of the activation domain of human methionine synthase
KR Wolthers, HS Toogood, TA Jowitt, KR Marshall, D Leys, NS Scrutton
The FEBS Journal 274 (3), 738-750, 2007
Mutagenesis of a conserved glutamate reveals the contribution of electrostatic energy to adenosylcobalamin Co–C bond homolysis in ornithine 4, 5-aminomutase and methylmalonyl …
C Makins, AV Pickering, C Mariani, KR Wolthers
Biochemistry 52 (5), 878-888, 2013
Reaction of Neuronal Nitric-Oxide Synthase with 2, 6-Dichloroindolphenol and Cytochrome c 3+: Influence of the Electron Acceptor and Binding of Ca2+-Activated Calmodulin on the …
KR Wolthers, MI Schimerlik
Biochemistry 40 (15), 4722-4737, 2001
ELDOR spectroscopy reveals that energy landscapes in human methionine synthase reductase are extensively remodelled following ligand and partner protein binding
SEJ Rigby, X Lou, HS Toogood, KR Wolthers, NS Scrutton
ChemBioChem 12 (6), 863-867, 2011
Tryptophan 697 modulates hydride and interflavin electron transfer in human methionine synthase reductase
CE Meints, FS Gustafsson, NS Scrutton, KR Wolthers
Biochemistry 50 (51), 11131-11142, 2011
Neuronal nitric oxide synthase: substrate and solvent kinetic isotope effects on the steady-state kinetic parameters for the reduction of 2, 6-dichloroindophenol and cytochrome …
KR Wolthers, MI Schimerlik
Biochemistry 41 (1), 196-204, 2002
Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADPH‐dependent flavin reduction
S Simtchouk, JL Eng, CE Meints, C Makins, KR Wolthers
The FEBS journal 280 (24), 6627-6642, 2013
Role of histidine 225 in adenosylcobalamin-dependent ornithine 4, 5-aminomutase
C Makins, FN Miros, NS Scrutton, KR Wolthers
Bioorganic chemistry 40, 39-47, 2012
Aromatic substitution of the FAD‐shielding tryptophan reveals its differential role in regulating electron flux in methionine synthase reductase and cytochrome P 450 reductase
CE Meints, S Simtchouk, KR Wolthers
The FEBS Journal 280 (6), 1460-1474, 2013
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