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Brock Schuman
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Glycosyltransferase structure and function
B Schuman, JA Alfaro, SV Evans
Bioactive Conformation I, 217-257, 2007
512007
Geometric attributes of retaining glycosyltransferase enzymes favor an orthogonal mechanism
B Schuman, SV Evans, TM Fyles
PLoS One 8 (8), e71077, 2013
452013
Sequence-dependent effects of cryoprotectants on the active sites of the human ABO (H) blood group A and B glycosyltransferases
AR Johal, B Schuman, JA Alfaro, S Borisova, NOL Seto, SV Evans
Acta Crystallographica Section D: Biological Crystallography 68 (3), 268-276, 2012
142012
Cysteine-to-serine mutants dramatically reorder the active site of human ABO (H) blood group B glycosyltransferase without affecting activity: structural insights into …
B Schuman, M Persson, RC Landry, R Polakowski, JT Weadge, NOL Seto, ...
Journal of molecular biology 402 (2), 399-411, 2010
132010
Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO (H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site
RJ Blackler, SML Gagnon, R Polakowski, NL Rose, RB Zheng, JA Letts, ...
Glycobiology 27 (4), 370-380, 2017
122017
The effect of heavy atoms on the conformation of the active-site polypeptide loop in human ABO (H) blood-group glycosyltransferase B
JA Letts, M Persson, B Schuman, SN Borisova, MM Palcic, SV Evans
Acta Crystallographica Section D: Biological Crystallography 63 (8), 860-865, 2007
112007
Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO (H) blood group A and B glycosyltransferases
SML Gagnon, MSG Legg, R Polakowski, JA Letts, M Persson, S Lin, ...
Glycobiology 28 (8), 624-636, 2018
82018
High-resolution crystal structures and STD NMR mapping of human ABO (H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular …
SML Gagnon, MSG Legg, N Sindhuwinata, JA Letts, AR Johal, ...
Glycobiology 27 (10), 966-977, 2017
82017
pH-induced conformational changes in human ABO (H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state
AR Johal, RJ Blackler, JA Alfaro, B Schuman, S Borisova, SV Evans
Glycobiology 24 (3), 237-246, 2014
82014
Bioactive conformation I
B Schuman, JA Alfaro, SV Evans, T Peters
Springer, 2007
82007
Preliminary joint neutron time-of-flight and X-ray crystallographic study of human ABO (H) blood group A glycosyltransferase
B Schuman, SZ Fisher, A Kovalevsky, SN Borisova, MM Palcic, L Coates, ...
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011
52011
Targeting RNA With Small Molecules
B Schuman
Drug Discovery Online, 2023
2023
Bespoke RNA-targeted drug design at the RNA/protein interface
B Schuman
Nature Biopharma Dealmakers, 2023
2023
Neutron structure and mutagenic analysis of human ABO bloodgroup glycosyltransferases support an orthogonal associative mechanism of stereospecificity
B Schuman, SML Gagnon, SN Borisova, TM Fyles, L Coates, P Langan, ...
Acta Crystallographica Section A: Foundations and Advances 74, a463-a463, 2018
2018
Non-steric-zipper models for pathogenic α-synuclein conformers
B Schuman, A Won, K Brand-Arzamendi, JB Koprich, XY Wen, ...
APL bioengineering 2 (2), 2018
2018
Structural and functional analysis of glycosyltransferase mechanisms
B Schuman
2012
Program and abstracts for the 2011 Meeting of the Society for Glycobiology.
M Hollingsworth, G Hart, J Paulson, E Stansell, K Canis, I Huang, ...
Glycobiology 21 (11), 2011
2011
Neutron structure of retaining glycosyltransferase GTA
B Schuman, SZ Fisher, S Borisova, MM Palcic, L Coates, PA Langan, ...
Acta Crystallographica Section A 67, C733-C734, 2011
2011
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