Justin A. MacDonald
Justin A. MacDonald
Professor of Biochemistry, University of Calgary
Verified email at - Homepage
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NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
SA Hirota, J Ng, A Lueng, M Khajah, K Parhar, Y Li, V Lam, MS Potentier, ...
Inflammatory bowel diseases 17 (6), 1359-1372, 2011
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
BD Gulbransen, M Bashashati, SA Hirota, X Gui, JA Roberts, ...
Nature medicine 18 (4), 600-604, 2012
Targeting aquaporin-4 subcellular localization to treat central nervous system edema
P Kitchen, MM Salman, AM Halsey, C Clarke-Bland, JA MacDonald, ...
Cell 181 (4), 784-799. e19, 2020
Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides
AA Wooldridge, JA MacDonald, F Erdodi, C Ma, MA Borman, ...
Journal of Biological Chemistry 279 (33), 34496-34504, 2004
Identification of the endogenous smooth muscle myosin phosphatase-associated kinase
JA MacDonald, MA Borman, A Murányi, AV Somlyo, DJ Hartshorne, ...
Proceedings of the National Academy of Sciences 98 (5), 2419-2424, 2001
Clostridium difficile toxin–induced inflammation and intestinal injury are mediated by the inflammasome
J Ng, SA Hirota, O Gross, Y Li, A Ulke–Lemee, MS Potentier, LP Schenck, ...
Gastroenterology 139 (2), 542-552. e3, 2010
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ
ME Grassie, LD Moffat, MP Walsh, JA MacDonald
Archives of biochemistry and biophysics 510 (2), 147-159, 2011
NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
L Mortimer, F Moreau, JA MacDonald, K Chadee
Nature immunology 17 (10), 1176-1186, 2016
Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase
A Murányi, JA MacDonald, JT Deng, DP Wilson, TAJ Haystead, MP Walsh, ...
Biochemical Journal 366 (1), 211-216, 2002
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ...
Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β
NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ...
Experimental physiology 98 (2), 462-472, 2013
Regulation of ground squirrel Na+ K+-ATPase activity by reversible phosphorylation during hibernation
JA MacDonald, KB Storey
Biochemical and biophysical research communications 254 (2), 424-429, 1999
C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats
JC Jones, HP Phatnani, TA Haystead, JA MacDonald, SM Alam, ...
Journal of Biological Chemistry 279 (24), 24957-24964, 2004
Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase
JA MacDonald, M Eto, MA Borman, DL Brautigan, TAJ Haystead
FEBS letters 493 (2-3), 91-94, 2001
Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle
DP Wilson, C Sutherland, MA Borman, JT Deng, JA MacDonald, ...
Biochemical Journal 392 (3), 641-648, 2005
Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome
JM Platnich, H Chung, A Lau, CF Sandall, A Bondzi-Simpson, HM Chen, ...
Cell reports 25 (6), 1525-1536. e7, 2018
Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition
MA Borman, JA MacDonald, A Murányi, DJ Hartshorne, TAJ Haystead
Journal of Biological Chemistry 277 (26), 23441-23446, 2002
Parasitic helminths: a pharmacopeia of anti-inflammatory molecules
MJG Johnston, JA MacDonald, DM McKay
Parasitology 136 (2), 125-147, 2009
Extracts of the Rat Tapeworm, Hymenolepis diminuta, Suppress Macrophage Activation In Vitro and Alleviate Chemically Induced Colitis in Mice
MJG Johnston, A Wang, MED Catarino, L Ball, VC Phan, JA MacDonald, ...
Infection and immunity 78 (3), 1364-1375, 2010
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury
SA Hirota, K Fines, J Ng, D Traboulsi, J Lee, E Ihara, Y Li, WG Willmore, ...
Gastroenterology 139 (1), 259-269. e3, 2010
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