|NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis|
SA Hirota, J Ng, A Lueng, M Khajah, K Parhar, Y Li, V Lam, MS Potentier, ...
Inflammatory bowel diseases 17 (6), 1359-1372, 2011
|Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis|
BD Gulbransen, M Bashashati, SA Hirota, X Gui, JA Roberts, ...
Nature medicine 18 (4), 600-604, 2012
|Targeting aquaporin-4 subcellular localization to treat central nervous system edema|
P Kitchen, MM Salman, AM Halsey, C Clarke-Bland, JA MacDonald, ...
Cell 181 (4), 784-799. e19, 2020
|Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides|
AA Wooldridge, JA MacDonald, F Erdodi, C Ma, MA Borman, ...
Journal of Biological Chemistry 279 (33), 34496-34504, 2004
|Identification of the endogenous smooth muscle myosin phosphatase-associated kinase|
JA MacDonald, MA Borman, A Murányi, AV Somlyo, DJ Hartshorne, ...
Proceedings of the National Academy of Sciences 98 (5), 2419-2424, 2001
|Clostridium difficile toxin–induced inflammation and intestinal injury are mediated by the inflammasome|
J Ng, SA Hirota, O Gross, Y Li, A Ulke–Lemee, MS Potentier, LP Schenck, ...
Gastroenterology 139 (2), 542-552. e3, 2010
|The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ|
ME Grassie, LD Moffat, MP Walsh, JA MacDonald
Archives of biochemistry and biophysics 510 (2), 147-159, 2011
|NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations|
L Mortimer, F Moreau, JA MacDonald, K Chadee
Nature immunology 17 (10), 1176-1186, 2016
|Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase|
A Murányi, JA MacDonald, JT Deng, DP Wilson, TAJ Haystead, MP Walsh, ...
Biochemical Journal 366 (1), 211-216, 2002
|The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter|
JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ...
Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012
|The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β|
NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ...
Experimental physiology 98 (2), 462-472, 2013
|Regulation of ground squirrel Na+ K+-ATPase activity by reversible phosphorylation during hibernation|
JA MacDonald, KB Storey
Biochemical and biophysical research communications 254 (2), 424-429, 1999
|C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats|
JC Jones, HP Phatnani, TA Haystead, JA MacDonald, SM Alam, ...
Journal of Biological Chemistry 279 (24), 24957-24964, 2004
|Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase|
JA MacDonald, M Eto, MA Borman, DL Brautigan, TAJ Haystead
FEBS letters 493 (2-3), 91-94, 2001
|Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle|
DP Wilson, C Sutherland, MA Borman, JT Deng, JA MacDonald, ...
Biochemical Journal 392 (3), 641-648, 2005
|Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome|
JM Platnich, H Chung, A Lau, CF Sandall, A Bondzi-Simpson, HM Chen, ...
Cell reports 25 (6), 1525-1536. e7, 2018
|Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition|
MA Borman, JA MacDonald, A Murányi, DJ Hartshorne, TAJ Haystead
Journal of Biological Chemistry 277 (26), 23441-23446, 2002
|Parasitic helminths: a pharmacopeia of anti-inflammatory molecules|
MJG Johnston, JA MacDonald, DM McKay
Parasitology 136 (2), 125-147, 2009
|Extracts of the Rat Tapeworm, Hymenolepis diminuta, Suppress Macrophage Activation In Vitro and Alleviate Chemically Induced Colitis in Mice|
MJG Johnston, A Wang, MED Catarino, L Ball, VC Phan, JA MacDonald, ...
Infection and immunity 78 (3), 1364-1375, 2010
|Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury|
SA Hirota, K Fines, J Ng, D Traboulsi, J Lee, E Ihara, Y Li, WG Willmore, ...
Gastroenterology 139 (1), 259-269. e3, 2010