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Alexander H. Stephan
Alexander H. Stephan
Team Leader, NRD/pRED, F. Hoffmann-La Roche Ltd.
Verified email at roche.com - Homepage
Title
Cited by
Cited by
Year
The complement system: an unexpected role in synaptic pruning during development and disease
AH Stephan, BA Barres, B Stevens
Annual review of neuroscience 35, 369-389, 2012
10742012
A dramatic increase of C1q protein in the CNS during normal aging
AH Stephan, DV Madison, JM Mateos, DA Fraser, EA Lovelett, ...
Journal of Neuroscience 33 (33), 13460-13474, 2013
4112013
Neurotrypsin cleaves agrin locally at the synapse
A Stephan, JM Mateos, SV Kozlov, P Cinelli, AD Kistler, S Hettwer, ...
The FASEB Journal 22 (6), 1861-1873, 2008
1502008
Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction
MF Bolliger, A Zurlinden, D Lüscher, L Bütikofer, O Shakhova, ...
Journal of cell science 123 (22), 3944-3955, 2010
1242010
Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation
R Reif, S Sales, S Hettwer, B Dreier, C Gisler, J Wölfel, D Lüscher, ...
The FASEB Journal 21 (13), 3468-3478, 2007
1152007
Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin
R Frischknecht, A Fejtova, M Viesti, A Stephan, P Sonderegger
Journal of Neuroscience 28 (7), 1568-1579, 2008
1072008
Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3
A Berg, J Zelano, A Stephan, S Thams, BA Barres, M Pekny, M Pekna, ...
Experimental neurology 237 (1), 8-17, 2012
652012
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA
L Kong, DO Valdivia, CM Simon, CW Hassinan, N Delestrée, DR Ramos, ...
Science Translational Medicine 13 (578), 2021
622021
Risdiplam, the First Approved Small Molecule Splicing Modifier Drug as a Blueprint for Future Transformative Medicines
H Ratni, RS Scalco, AH Stephan
ACS Medicinal Chemistry Letters, 2021
482021
Molecular characterization of a trafficking organelle: Dissecting the axonal paths of calsyntenin‐1 transport vesicles
M Steuble, B Gerrits, A Ludwig, JM Mateos, TM Diep, M Tagaya, ...
Proteomics 10 (21), 3775-3788, 2010
372010
Modulation of synaptic maintenance
BA Barres, AH Stephan, BA Stevens
US Patent 9,480,658, 2016
312016
Modulation of Synaptic Maintenance
BA Barres, AH Stephan, BA Stevens
US Patent 20,120,328,601, 2012
31*2012
Emergence of lamina-specific retinal ganglion cell connectivity by axon arbor retraction and synapse elimination
TW Cheng, XB Liu, RL Faulkner, AH Stephan, BA Barres, AD Huberman, ...
Journal of Neuroscience 30 (48), 16376-16382, 2010
242010
Nocturnal accumulation of cyclic 3′, 5′‐guanosine monophosphate (cGMP) in the chick pineal organ is dependent on activation of guanylyl cyclase‐B
J Olcese, C Majora, A Stephan, D Müller
Journal of neuroendocrinology 14 (1), 14-18, 2002
102002
Modulation of synaptic maintenance
BA Barres, AH Stephan, BA Stevens
US Patent 10,240,156, 2019
32019
Method for the detection of the in-vivo activity of neurotrypsin, use of the method and use of the c-terminal, 22-kda fragment of agrin as biomarker in diagnosis and monitoring …
P Sonderegger, S Hettwer, A Stephan, K Miyai, B Kunz
US Patent App. 12/599,456, 2010
22010
Method for the detection of the in-vivo activity of neurotrypsin, use of the method and use of the c-terminal, 22-kda fragment of agrin as biomarker in diagnosis and monitoring …
P Sonderegger, S Hettwer, A Stephan, K Miyai, B Kunz
US Patent App. 12/599,456, 2010
22010
Method for the detection of the in-vivo activity of neurotrypsin, use of the method and use of the c-terminal, 22-kda fragment of agrin as biomarker in diagnosis and monitoring …
P Sonderegger, S Hettwer, A Stephan, K Miyai, B Kunz
US Patent App. 12/599,456, 2010
22010
A role for C1q in normal brain aging
AH Stephan, DV Madison, JM Mateos, D Fraser, L Coutellier, E Lovelett, ...
Immunobiology 217 (11), 1133, 2012
12012
SMN2 Splicing Modification by Small Molecules–A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases
H Ratni, M Ebeling, RS Scalco, L Mueller, A Stephan
The Handbook of Medicinal Chemistry, 830-846, 2023
2023
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