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Motoyuki Otsuka
Motoyuki Otsuka
Department of Gastroenterology, The University of Tokyo
Verified email at umin.ac.jp
Title
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Cited by
Year
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression
M Otsuka, Q Jing, P Georgel, L New, J Chen, J Mols, YJ Kang, Z Jiang, ...
Immunity 27 (1), 123-134, 2007
4462007
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
V Kumar, N Kato, Y Urabe, A Takahashi, R Muroyama, N Hosono, ...
Nature genetics 43 (5), 455-458, 2011
4362011
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
M Otsuka, M Zheng, M Hayashi, JD Lee, O Yoshino, S Lin, J Han
The Journal of clinical investigation 118 (5), 1944-1954, 2008
4102008
Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer
N Kato, H Yoshida, SK Ono-Nita, J Kato, T Goto, M Otsuka, K Lan, ...
Hepatology 32 (2), 405-412, 2000
3472000
Full-length cDNA
T Isogai, T Sugiyama, T Otsuki, A Wakamatsu, H Sato, S Ishii, ...
US Patent 6,943,241, 2005
3242005
Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease
T Soga, M Sugimoto, M Honma, M Mori, K Igarashi, K Kashikura, S Ikeda, ...
Journal of hepatology 55 (4), 896-905, 2011
2542011
Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection
Y Wang, N Kato, Y Hoshida, H Yoshida, H Taniguchi, T Goto, M Moriyama, ...
Hepatology 37 (1), 65-71, 2003
2192003
Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability
M Otsuka, N Kato, KH Lan, H Yoshida, J Kato, T Goto, Y Shiratori, ...
Journal of Biological Chemistry 275 (44), 34122-34130, 2000
2142000
Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation
YJ Kang, J Chen, M Otsuka, J Mols, S Ren, Y Wang, J Han
The Journal of Immunology 180 (7), 5075-5082, 2008
1872008
Hepatitis C virus core protein upregulates transforming growth factor‐β1 transcription
H Taniguchi, N Kato, M Otsuka, T Goto, H Yoshida, Y Shiratori, M Omata
Journal of medical virology 72 (1), 52-59, 2004
1772004
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
M Otsuka, N Kato, M Moriyama, H Taniguchi, Y Wang, N Dharel, ...
Hepatology 41 (5), 1004-1012, 2005
1742005
Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation
M Otsuka, N Kato, RX Shao, Y Hoshida, H Ijichi, Y Koike, H Taniguchi, ...
Hepatology 40 (1), 243-251, 2004
1722004
Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response
Y Wang, N Kato, A Jazag, N Dharel, M Otsuka, H Taniguchi, T Kawabe, ...
Gastroenterology 130 (3), 883-892, 2006
1422006
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
K Kojima, A Takata, C Vadnais, M Otsuka, T Yoshikawa, M Akanuma, ...
Nature communications 2 (1), 338, 2011
1382011
MicroRNA‐140 acts as a liver tumor suppressor by controlling NF‐κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression
A Takata, M Otsuka, T Yoshikawa, T Kishikawa, Y Hikiba, S Obi, T Goto, ...
Hepatology 57 (1), 162-170, 2013
1322013
Hepatitis C virus core protein activates nuclear factor κB-dependent signaling through tumor necrosis factor receptor-associated factor
H Yoshida, N Kato, Y Shiratori, M Otsuka, S Maeda, J Kato, M Omata
Journal of Biological Chemistry 276 (19), 16399-16405, 2001
1322001
Cell surface 4-1BBL mediates sequential signaling pathways' downstream'of TLR and is required for sustained TNF production in macrophages
YJ Kang, SO Kim, S Shimada, M Otsuka, A Seit-Nebi, BS Kwon, TH Watts, ...
Nature immunology 8 (6), 601-609, 2007
1312007
Calcineurin negatively regulates TLR-mediated activation pathways
YJ Kang, B Kusler, M Otsuka, M Hughes, N Suzuki, S Suzuki, WC Yeh, ...
The Journal of Immunology 179 (7), 4598-4607, 2007
1292007
Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis
M Otsuka, M Kato, T Yoshikawa, H Chen, EJ Brown, Y Masuho, M Omata, ...
Biochemical and Biophysical Research Communications 289 (4), 876-881, 2001
1272001
Smad4-independent regulation of p21/WAF1 by transforming growth factor-β
H Ijichi, M Otsuka, K Tateishi, T Ikenoue, T Kawakami, F Kanai, Y Arakawa, ...
Oncogene 23 (5), 1043-1051, 2004
1202004
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