| A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity M Lebel, P Leder Proceedings of the national academy of sciences 95 (22), 13097-13102, 1998 | 345 | 1998 |
| The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I M Lebel, EA Spillare, CC Harris, P Leder Journal of Biological Chemistry 274 (53), 37795-37799, 1999 | 285 | 1999 |
| Novel DNA mismatch-repair activity involving YB-1 in human mitochondria NC de Souza-Pinto, PA Mason, K Hashiguchi, L Weissman, J Tian, ... DNA repair 8 (6), 704-719, 2009 | 250 | 2009 |
| Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway PR Laud, AS Multani, SM Bailey, L Wu, J Ma, C Kingsley, M Lebel, ... Genes & development 19 (21), 2560-2570, 2005 | 219 | 2005 |
| YB‐1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds … I Gaudreault, D Guay, M Lebel Nucleic acids research 32 (1), 316-327, 2004 | 198 | 2004 |
| Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome FV Pallardó, A Lloret, M Lebel, M d’Ischia, VC Cogger, DG Le Couteur, ... Biogerontology 11, 401-419, 2010 | 124 | 2010 |
| Vitamin C restores healthy aging in a mouse model for Werner syndrome L Massip, C Garand, ER Paquet, VC Cogger, JN O’Reilly, L Tworek, ... FASEB journal: official publication of the Federation of American Societies …, 2010 | 112 | 2010 |
| Genetic cooperation between the Werner syndrome protein and poly (ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice M Lebel, J Lavoie, I Gaudreault, M Bronsard, R Drouin The American journal of pathology 162 (5), 1559-1569, 2003 | 102 | 2003 |
| NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines SP Tsofack, C Garand, C Sereduk, D Chow, M Aziz, D Guay, HH Yin, ... Molecular cancer 10, 1-18, 2011 | 80 | 2011 |
| Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase M Lebel, RD Cardiff, P Leder Cancer research 61 (5), 1816-1819, 2001 | 79 | 2001 |
| Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome A Labbé, C Garand, VC Cogger, ER Paquet, M Desbiens, DG Le Couteur, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2011 | 77 | 2011 |
| Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue L Massip, C Garand, RVN Turaga, F Deschênes, E Thorin, M Lebel Experimental gerontology 41 (2), 157-168, 2006 | 76 | 2006 |
| Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis SP Tsofack, L Meunier, L Sanchez, J Madore, D Provencher, ... BMC cancer 13, 1-12, 2013 | 55 | 2013 |
| Liver aging and pseudocapillarization in a Werner syndrome mouse model VC Cogger, D Svistounov, A Warren, S Zykova, RG Melvin, SM Solon-Biet, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2014 | 54 | 2014 |
| Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples S Lachapelle, JP Gagné, C Garand, M Desbiens, Y Coulombe, VA Bohr, ... Journal of proteome research 10 (3), 1216-1227, 2011 | 53 | 2011 |
| The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses RVN Turaga, ER Paquet, M Sild, J Vignard, C Garand, FB Johnson, ... Cell cycle 8 (13), 2080-2092, 2009 | 51 | 2009 |
| The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y‐box‐binding protein‐1 overexpressing tumor cells D Guay, C Garand, S Reddy, C Schmutte, M Lebel Cancer science 99 (4), 762-769, 2008 | 51 | 2008 |
| Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases M Lebel, RJ Monnat Jr Ageing research reviews 41, 82-97, 2018 | 46 | 2018 |
| In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly … F Deschênes, L Massip, C Garand, M Lebel Human molecular genetics 14 (21), 3293-3308, 2005 | 45 | 2005 |
| Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue M Lebel Carcinogenesis 23 (1), 213-216, 2002 | 43 | 2002 |
