| Dominant-activating germline mutations in the gene encoding the PI (3) K catalytic subunit p110δ result in T cell senescence and human immunodeficiency CL Lucas, HS Kuehn, F Zhao, JE Niemela, EK Deenick, U Palendira, ... Nature immunology 15 (1), 88-97, 2014 | 826 | 2014 |
| Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: a cohort study E Elkaim, B Neven, J Bruneau, K Mitsui-Sekinaka, A Stanislas, L Heurtier, ... Journal of Allergy and Clinical Immunology 138 (1), 210-218. e9, 2016 | 426 | 2016 |
| Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D B Chaigne-Delalande, FY Li, GM O’Connor, MJ Lukacs, P Jiang, L Zheng, ... Science 341 (6142), 186-191, 2013 | 366 | 2013 |
| PI3Kδ and primary immunodeficiencies CL Lucas, A Chandra, S Nejentsev, AM Condliffe, K Okkenhaug Nature Reviews Immunology 16 (11), 702-714, 2016 | 308 | 2016 |
| Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K CL Lucas, Y Zhang, A Venida, Y Wang, J Hughes, J McElwee, M Butrick, ... Journal of Experimental Medicine 211 (13), 2537-2547, 2014 | 283 | 2014 |
| Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib VK Rao, S Webster, VASH Dalm, A Šedivá, PM van Hagen, S Holland, ... Blood 130 (21), 2307-2316, 2017 | 262 | 2017 |
| A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection JL Casanova, HC Su, L Abel, A Aiuti, S Almuhsen, AA Arias, P Bastard, ... Cell 181 (6), 1194-1199, 2020 | 252 | 2020 |
| Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children A Ramaswamy, NN Brodsky, TS Sumida, M Comi, H Asashima, ... Immunity 54 (5), 1083-1095. e7, 2021 | 202 | 2021 |
| HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation ML Del Rio, CL Lucas, L Buhler, G Rayat, JI Rodriguez‐Barbosa Journal of leukocyte biology 87 (2), 223-235, 2010 | 189 | 2010 |
| Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene RT Dackor, K Fritz-Six, WP Dunworth, CL Gibbons, O Smithies, KM Caron Molecular and cellular biology 26 (7), 2511-2518, 2006 | 155 | 2006 |
| SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease? V Sancho-Shimizu, P Brodin, A Cobat, CM Biggs, J Toubiana, CL Lucas, ... Journal of Experimental Medicine 218 (6), e20210446, 2021 | 138 | 2021 |
| Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling C Gibbons, R Dackor, W Dunworth, K Fritz-Six, KM Caron Molecular endocrinology 21 (4), 783-796, 2007 | 132 | 2007 |
| Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1 GL Dornan, BD Siempelkamp, ML Jenkins, O Vadas, CL Lucas, JE Burke Proceedings of the National Academy of Sciences 114 (8), 1982-1987, 2017 | 107 | 2017 |
| Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway F Haspot, T Fehr, C Gibbons, G Zhao, T Hogan, T Honjo, GJ Freeman, ... Blood, The Journal of the American Society of Hematology 112 (5), 2149-2155, 2008 | 93 | 2008 |
| Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans AJ Takeda, Y Zhang, GL Dornan, BD Siempelkamp, ML Jenkins, ... Journal of Allergy and Clinical Immunology 140 (4), 1152-1156. e10, 2017 | 71 | 2017 |
| Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology AJ Takeda, TJ Maher, Y Zhang, SM Lanahan, ML Bucklin, SR Compton, ... Nature communications 10 (1), 1-12, 2019 | 55 | 2019 |
| LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L CL Lucas, CJ Workman, S Beyaz, S LoCascio, G Zhao, DAA Vignali, ... Blood, The Journal of the American Society of Hematology 117 (20), 5532-5540, 2011 | 50 | 2011 |
| A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo T Fehr, CL Lucas, J Kurtz, T Onoe, G Zhao, T Hogan, C Vallot, A Rao, ... Blood, The Journal of the American Society of Hematology 115 (6), 1280-1287, 2010 | 50 | 2010 |
| Genomics of immune diseases and new therapies M Lenardo, B Lo, CL Lucas Annual review of immunology 34, 2016 | 48 | 2016 |
| Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients H Hashem, G Bucciol, S Ozen, S Unal, IO Bozkaya, N Akarsu, M Taskinen, ... Journal of clinical immunology, 1-15, 2021 | 47 | 2021 |
