Patrick Lague
Patrick Lague
Département de Biochimie, de Microbiology et de Bio-informatique, Université Laval
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Pressure-based long-range correction for Lennard-Jones interactions in molecular dynamics simulations: application to alkanes and interfaces
P Lagüe, RW Pastor, BR Brooks
The Journal of Physical Chemistry B 108 (1), 363-368, 2004
Lipid-mediated interactions between intrinsic membrane proteins: dependence on protein size and lipid composition
P Lagüe, MJ Zuckermann, B Roux
Biophysical journal 81 (1), 276-284, 2001
Efficient restoration of the dystrophin gene reading frame and protein structure in DMD myoblasts using the CinDel method
JP Iyombe-Engembe, DL Ouellet, X Barbeau, J Rousseau, ...
Molecular Therapy-Nucleic Acids 5, 2016
Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids
P Lagüe, B Roux, RW Pastor
Journal of molecular biology 354 (5), 1129-1141, 2005
CRISPR-induced deletion with saCas9 restores dystrophin expression in dystrophic models in vitro and in vivo
BL Duchêne, K Cherif, JP Iyombe-Engembe, A Guyon, J Rousseau, ...
Molecular Therapy 26 (11), 2604-2616, 2018
Lipid-mediated interactions between intrinsic membrane proteins: a theoretical study based on integral equations
P Lagüe, MJ Zuckermann, B Roux
Biophysical journal 79 (6), 2867-2879, 2000
TEM-1 backbone dynamics—insights from combined molecular dynamics and nuclear magnetic resonance
O Fisette, S Morin, PY Savard, P Lagüe, SM Gagné
Biophysical journal 98 (4), 637-645, 2010
Synergistic applications of MD and NMR for the study of biological systems
O Fisette, P Lagüe, S Gagné, S Morin
BioMed Research International 2012, 2012
Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-(m-carbamoylbenzyl)-estradiol Derivatives
R Maltais, D Ayan, A Trottier, X Barbeau, P Lagüe, JE Bouchard, ...
Journal of medicinal chemistry 57 (1), 204-222, 2014
Protein inclusion in lipid membranes: a theory based on the hypernetted chain integral equation
P Lagüe, MJ Zuckermann, B Roux
Faraday discussions 111, 165-172, 1999
Quinazoline‐4‐piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells
EE Shayhidin, E Forcellini, MC Boulanger, A Mahmut, S Dautrey, ...
British journal of pharmacology 172 (16), 4189-4199, 2015
Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations
R Daigle, M Guertin, P Lagüe
Proteins: Structure, Function, and Bioinformatics 75 (3), 735-747, 2009
Antibiotic resistance due to an unusual ColE1-type replicon plasmid in Aeromonas salmonicida
AT Vincent, JG Emond-Rheault, X Barbeau, SA Attéré, M Frenette, ...
Microbiology 162 (6), 942-953, 2016
Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water
YH Ouellet, R Daigle, P Lagüe, D Dantsker, M Milani, M Bolognesi, ...
Journal of Biological Chemistry 283 (40), 27270-27278, 2008
Determining the mode of action involved in the antimicrobial activity of synthetic peptides: a solid-state NMR and FTIR study
A Lorin, M Noël, MÈ Provencher, V Turcotte, S Cardinal, P Lagüe, ...
Biophysical journal 103 (7), 1470-1479, 2012
Is there nascent structure in the intrinsically disordered region of troponin I?
O Julien, P Mercier, CN Allen, O Fisette, CHI Ramos, P Lagüe, ...
Proteins: Structure, Function, and Bioinformatics 79 (4), 1240-1250, 2011
Theoretical investigations of nitric oxide channeling in Mycobacterium tuberculosis truncated hemoglobin N
R Daigle, JA Rousseau, M Guertin, P Lagüe
Biophysical journal 97 (11), 2967-2977, 2009
Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties
C Ouellet, R Maltais, É Ouellet, X Barbeau, P Lagüe, D Poirier
European Journal of Medicinal Chemistry 119, 169-182, 2016
Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations
PY Savard, R Daigle, S Morin, A Sebilo, F Meindre, P Lagüe, M Guertin, ...
Biochemistry 50 (51), 11121-11130, 2011
The influenza fusion peptide promotes lipid polar head intrusion through hydrogen bonding with phosphates and N‐terminal membrane insertion depth
S Légaré, P Lagüe
Proteins: Structure, Function, and Bioinformatics 82 (9), 2118-2127, 2014
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