PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo KL Veiman, K Künnapuu, T Lehto, K Kiisholts, K Pärn, Ü Langel, ... Journal of Controlled Release 209, 238-247, 2015 | 132 | 2015 |
PepFect14 peptide vector for efficient gene delivery in cell cultures KL Veiman, I Mäger, K Ezzat, H Margus, T Lehto, K Langel, K Kurrikoff, ... Molecular pharmaceutics 10 (1), 199-210, 2013 | 101 | 2013 |
Saturated fatty acid analogues of cell-penetrating peptide PepFect14: role of fatty acid modification in complexation and delivery of splice-correcting oligonucleotides T Lehto, L Vasconcelos, H Margus, R Figueroa, M Pooga, M Hällbrink, ... Bioconjugate chemistry 28 (3), 782-792, 2017 | 49 | 2017 |
Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide K Kurrikoff, KL Veiman, K Künnapuu, EM Peets, T Lehto, L Pärnaste, ... Scientific reports 7 (1), 17056, 2017 | 40 | 2017 |
Efficient peptide-mediated in vitro delivery of Cas9 RNP O Gustafsson, J Rädler, S Roudi, T Lehto, M Hällbrink, T Lehto, D Gupta, ... Pharmaceutics 13 (6), 878, 2021 | 27 | 2021 |
Peptide-based vectors: recent developments CP Cerrato, T Lehto, Ü Langel Biomolecular concepts 5 (6), 479-488, 2014 | 25 | 2014 |
Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides CP Cerrato, T Kivijärvi, R Tozzi, T Lehto, M Gestin, Ü Langel Journal of Materials Chemistry B 8 (47), 10825-10836, 2020 | 19 | 2020 |
Refinement of a quantitative structure–activity relationship model for prediction of cell-penetrating peptide based transfection systems M Dowaidar, J Regberg, DA Dobchev, T Lehto, M Hällbrink, M Karelson, ... International Journal of Peptide Research and Therapeutics 23, 91-100, 2017 | 19 | 2017 |
Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy L Vasconcelos, T Lehto, F Madani, V Radoi, M Hällbrink, V Vukojević, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (2), 491-504, 2018 | 16 | 2018 |
Astrocytes promote ethanol-induced enhancement of intracellular Ca2+ signals through intercellular communication with neurons HB Kim, J Morris, K Miyashiro, T Lehto, Ü Langel, J Eberwine, JY Sul Iscience 24 (5), 2021 | 9 | 2021 |
Novel orthogonally hydrocarbon-modified cell-penetrating peptide nanoparticles mediate efficient delivery of splice-switching antisense oligonucleotides in vitro and in vivo S Bazaz, T Lehto, R Tops, O Gissberg, D Gupta, B Bestas, J Bost, ... Biomedicines 9 (8), 1046, 2021 | 6 | 2021 |
Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations T Lehto Department of Biochemistry and Biophysics, Stockholm University, 2018 | 1 | 2018 |
Guidelines for developing safe and efficient acylated cell-penetrating peptides for nanoparticle mediated non-covalent nucleic acid delivery in vivo T Lehto | | 2018 |
Principles of in vivo nucleic acid delivery with acylated cell-penetrating peptides T Lehto, KL Veiman, M Hällbrink, Ü Langel | | |