Lyle McKinnon
Lyle McKinnon
University of Manitoba
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The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
C Cicala, E Martinelli, JP McNally, DJ Goode, R Gopaul, J Hiatt, K Jelicic, ...
Proceedings of the National Academy of Sciences 106 (49), 20877-20882, 2009
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
NR Klatt, R Cheu, K Birse, AS Zevin, M Perner, L NoŽl-Romas, A Grobler, ...
Science 356 (6341), 938-945, 2017
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
SN Byrareddy, J Arthos, C Cicala, F Villinger, KT Ortiz, D Little, N Sidell, ...
Science 354 (6309), 197-202, 2016
Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection
RT Lester, XD Yao, TB Ball, LR McKinnon, R Kaul, C Wachihi, W Jaoko, ...
Aids 22 (6), 685-694, 2008
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
LR McKinnon, B Nyanga, D Chege, P Izulla, M Kimani, S Huibner, ...
The Journal of Immunology 187 (11), 6032-6042, 2011
Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study
L Masson, K Mlisana, F Little, L Werner, NN Mkhize, K Ronacher, ...
Sexually transmitted infections 90 (8), 580-587, 2014
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV†…
KB Arnold, A Burgener, K Birse, L Romas, LJ Dunphy, K Shahabi, M Abou, ...
Mucosal immunology 9 (1), 194-205, 2016
Microbial translocation and microbiome dsybiosis in HIV-associated immune activation
AS Zevin, L McKinnon, A Burgener, NR Klatt
Current opinion in HIV and AIDS 11 (2), 182, 2016
Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation
CJ Kim, LR McKinnon, C Kovacs, G Kandel, S Huibner, D Chege, ...
The Journal of Immunology 191 (5), 2164-2173, 2013
Quality and quantity: mucosal CD4+ T cells and HIV susceptibility
LR McKinnon, R Kaul
Current Opinion in HIV and AIDS 7 (2), 195-202, 2012
HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers
RT Lester, XD Yao, TB Ball, LR McKinnon, WR Omange, R Kaul, ...
PloS one 4 (5), e5644, 2009
Microbiome composition and function drives wound-healing impairment in the female genital tract
AS Zevin, IY Xie, K Birse, K Arnold, L Romas, G Westmacott, RM Novak, ...
PLoS pathogens 12 (9), e1005889, 2016
Identification of preferential CD4+ T-cell targets for HIV infection in the cervix
VR Joag, LR McKinnon, J Liu, ST Kidane, MH Yudin, B Nyanga, ...
Mucosal immunology 9 (1), 1-12, 2016
Biological factors that may contribute to regional and racial disparities in HIV prevalence
R Kaul, CR Cohen, D Chege, TJ Yi, W Tharao, LR McKinnon, R Remis, ...
American Journal of Reproductive Immunology 65 (3), 317-324, 2011
Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya
D Chege, Y Chai, S Huibner, T Kain, C Wachihi, M Kimani, S Barasa, ...
PloS one 7 (8), e43670, 2012
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women
LR McKinnon, LJ Liebenberg, N Yende-Zuma, D Archary, S Ngcapu, ...
Nature medicine 24 (4), 491, 2018
Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes
A Sivro, A Schuetz, D Sheward, V Joag, S Yegorov, LJ Liebenberg, ...
Science translational medicine 10 (425), 2018
Genital immunology and HIV susceptibility in young women
TJ Yi, B Shannon, J Prodger, L McKinnon, R Kaul
American Journal of Reproductive Immunology 69, 74-79, 2013
Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV
RE Horton, TB Ball, C Wachichi, W Jaoko, WJ Rutherford, L Mckinnon, ...
AIDS research and human retroviruses 25 (1), 83-92, 2009
High HIV risk in a cohort of male sex workers from Nairobi, Kenya
LR McKinnon, G Gakii, JA Juno, P Izulla, J Munyao, N Ireri, CW Kariuki, ...
Sexually transmitted infections 90 (3), 237-242, 2014
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