| Diversity-oriented synthesis yields novel multistage antimalarial inhibitors N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ... Nature 538 (7625), 344-349, 2016 | 250 | 2016 |
| Architecture of eukaryotic mRNA 3′-end processing machinery A Casañal, A Kumar, CH Hill, AD Easter, P Emsley, G Degliesposti, ... Science 358 (6366), 1056-1059, 2017 | 133 | 2017 |
| The genetic and biochemical basis of FANCD2 monoubiquitination E Rajendra, VH Oestergaard, F Langevin, M Wang, GL Dornan, KJ Patel, ... Molecular cell 54 (5), 858-869, 2014 | 131 | 2014 |
| Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1 GL Dornan, BD Siempelkamp, ML Jenkins, O Vadas, CL Lucas, JE Burke Proceedings of the National Academy of Sciences 114 (8), 1982-1987, 2017 | 107 | 2017 |
| Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans AJ Takeda, Y Zhang, GL Dornan, BD Siempelkamp, ML Jenkins, ... Journal of Allergy and Clinical Immunology 140 (4), 1152-1156. e10, 2017 | 71 | 2017 |
| Molecular mechanisms of human disease mediated by oncogenic and primary immunodeficiency mutations in class IA phosphoinositide 3-kinases GL Dornan, JE Burke Frontiers in immunology 9, 352188, 2018 | 70 | 2018 |
| Using hydrogen–deuterium exchange mass spectrometry to examine protein–membrane interactions O Vadas, ML Jenkins, GL Dornan, JE Burke Methods in enzymology 583, 143-172, 2017 | 68 | 2017 |
| Design and structural characterization of potent and selective inhibitors of phosphatidylinositol 4 kinase IIIβ FU Rutaganira, ML Fowler, JA McPhail, MA Gelman, K Nguyen, A Xiong, ... Journal of medicinal chemistry 59 (5), 1830-1839, 2016 | 60 | 2016 |
| Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease GL Dornan, JA McPhail, JE Burke Biochemical Society transactions 44 (1), 260-266, 2016 | 40 | 2016 |
| Probing the architecture, dynamics, and inhibition of the PI4KIIIα/TTC7/FAM126 complex GL Dornan, U Dalwadi, DJ Hamelin, RM Hoffmann, CK Yip, JE Burke Journal of molecular biology 430 (18), 3129-3142, 2018 | 27 | 2018 |
| The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology PA Koch, GL Dornan, M Hessenberger, V Haucke The FEBS Journal 288 (24), 7025-7042, 2021 | 18 | 2021 |
| Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases GL Dornan, JTB Stariha, MK Rathinaswamy, CJ Powell, MJ Boulanger, ... Structure 28 (2), 145-156. e5, 2020 | 15 | 2020 |
| Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs S Hostachy, T Utesch, K Franke, GL Dornan, D Furkert, B Türkaydin, ... Chemical science 12 (32), 10696-10702, 2021 | 10 | 2021 |
| Nutrient-regulated control of lysosome function by signaling lipid conversion M Ebner, D Puchkov, O López-Ortega, P Muthukottiappan, Y Su, ... Cell 186 (24), 5328-5346. e26, 2023 | 8 | 2023 |
| Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase JL Gorenflos López, GL Dornan, N Boback, M Neuenschwander, A Oder, ... ChemBioChem 24 (24), e202300555, 2023 | | 2023 |
| An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor T Aguirre, GL Dornan, S Hostachy, M Neuenschwander, C Seyffarth, ... Elife 12, RP88982, 2023 | | 2023 |
| Defining the molecular mechanisms mediating class IA phosphoinositide 3-kinase (PI3K) regulation and their role in human disease GL Dornan | | 2019 |
| Defining allosteric mechanisms of PI3K signaling using hydrogen deuterium exchange mass spectrometry. GL Dornan, BD Siempelkamp, ML Jenkins, CL Lucas, JE Burke MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018 | | 2018 |
| rsc. li/chemical-science S Meyer, J Häfliger, R Gilmour, S Hostachy, T Utesch, K Franke, ... | | |
John E BurkeProfessor of Biochemistry and Microbiology, University of VictoriaVerified email at uvic.ca
