Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment K Jaroch, A Jaroch, B Bojko Journal of Pharmaceutical and Biomedical Analysis 147, 297-312, 2018 | 97 | 2018 |
Combretastatins: In vitro structure-activity relationship, mode of action and current clinical status K Jaroch, M Karolak, P Górski, A Jaroch, A Krajewski, A Ilnicka, ... Pharmacological Reports 68, 1266-1275, 2016 | 72 | 2016 |
Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design … K Piechowska, M Świtalska, J Cytarska, K Jaroch, K Łuczykowski, ... European journal of medicinal chemistry 175, 162-171, 2019 | 43 | 2019 |
New chemical biopsy tool for spatially resolved profiling of human brain tissue in vivo J Bogusiewicz, K Burlikowska, K Łuczykowski, K Jaroch, M Birski, J Furtak, ... Scientific Reports 11 (1), 19522, 2021 | 24 | 2021 |
SPME as a promising tool in translational medicine and drug discovery: From bench to bedside K Goryński, P Goryńska, A Górska, T Harężlak, A Jaroch, K Jaroch, ... Journal of Pharmaceutical and Biomedical Analysis 130, 55-67, 2016 | 23 | 2016 |
The use of solid phase microextraction for metabolomic analysis of non-small cell lung carcinoma cell line (A549) after administration of combretastatin A4 K Jaroch, E Boyaci, J Pawliszyn, B Bojko Scientific Reports 9 (1), 402, 2019 | 20 | 2019 |
Comparison of metabolomic profiles of organs in mice of different strains based on SPME-LC-HRMS K Burlikowska, I Stryjak, J Bogusiewicz, B Kupcewicz, K Jaroch, B Bojko Metabolites 10 (6), 255, 2020 | 19 | 2020 |
Tropinone-derived alkaloids as potent anticancer agents: Synthesis, tyrosinase inhibition, mechanism of action, DFT calculation, and molecular docking studies K Piechowska, M Mizerska-Kowalska, B Zdzisińska, J Cytarska, ... International Journal of Molecular Sciences 21 (23), 9050, 2020 | 18 | 2020 |
Antimicrobial and cytotoxic activity of novel imidazolium-based ionic liquids Ł Pałkowski, M Karolak, A Skrzypczak, M Wojcieszak, F Walkiewicz, ... Molecules 27 (6), 1974, 2022 | 13 | 2022 |
Untargeted screening of phase I metabolism of combretastatin A4 by multi-tool analysis K Jaroch, PZ Goryńska, K Goryński, T Stefański, B Bojko Talanta 182, 22-31, 2018 | 13 | 2018 |
Application of thin-film microextraction to analyze volatile metabolites in a549 cancer cells W Filipiak, K Jaroch, P Szeliska, K Żuchowska, B Bojko Metabolites 11 (10), 704, 2021 | 12 | 2021 |
Profiling of carnitine shuttle system intermediates in gliomas using solid-phase microextraction (Spme) J Bogusiewicz, K Burlikowska, K Jaroch, PZ Gorynska, K Gorynski, ... Molecules 26 (20), 6112, 2021 | 12 | 2021 |
Glioblastoma metabolomics—in vitro studies K Jaroch, P Modrakowska, B Bojko Metabolites 11 (5), 315, 2021 | 11 | 2021 |
Investigating the potential use of chemical biopsy devices to characterize brain tumor lipidomes J Bogusiewicz, B Kupcewicz, PZ Goryńska, K Jaroch, K Goryński, M Birski, ... International Journal of Molecular Sciences 23 (7), 3518, 2022 | 10 | 2022 |
One extraction tool for in vitro-in vivo extrapolation? SPME-based metabolomics of in vitro 2D, 3D, and in vivo mouse melanoma models K Jaroch, P Taczyńska, M Czechowska, J Bogusiewicz, K Łuczykowski, ... Journal of Pharmaceutical Analysis 11 (5), 667-674, 2021 | 10 | 2021 |
Metabolomic phenotyping of gliomas: what can we get with simplified protocol for intact tissue analysis? PZ Goryńska, K Chmara, B Kupcewicz, K Goryński, K Jaroch, ... Cancers 14 (2), 312, 2022 | 9 | 2022 |
Time-course monitoring of in vitro biotransformation reaction via solid-phase microextraction-ambient mass spectrometry approaches K Jaroch, J Pawliszyn Journal of Pharmaceutical Analysis 12 (1), 186-191, 2022 | 8 | 2022 |
On-site sampling and extraction of brain tumors for metabolomics and lipidomics analysis J Bogusiewicz, PZ Goryńska, M Gaca, K Chmara, K Goryński, K Jaroch, ... JoVE (Journal of Visualized Experiments), e61260, 2020 | 8 | 2020 |
Coated blade spray-mass spectrometry as a new approach for the rapid characterization of brain tumors J Bogusiewicz, M Gaca-Tabaszewska, D Olszówka, K Jaroch, J Furtak, ... Molecules 27 (7), 2251, 2022 | 7 | 2022 |
Selected drug-likeness properties of 2-arylidene-indan-1, 3-dione derivatives—chemical compounds with potential anti-cancer activity R Pluskota, K Jaroch, P Kośliński, B Ziomkowska, A Lewińska, ... Molecules 26 (17), 5256, 2021 | 3 | 2021 |