Sean Egan
Sean Egan
Cell Biology Program - The Hospital for Sick Children
Verified email at
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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
SE Egan, BW Giddings, MW Brooks, L Buday, AM Sizeland, RA Weinberg
Nature 363 (6424), 45-51, 1993
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
M Reedijk, S Odorcic, L Chang, H Zhang, N Miller, DR McCready, ...
Cancer research. 65 (18), 8530-7, 2005
The pathway to signal achievement.
SE Egan, RA Weinberg
Nature 365 (6449), 1993
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.
L Buday, SE Egan, PR Viciana, DA Cantrell, J Downward
Journal of Biological Chemistry 269 (12), 9019-9023, 1994
The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15
AS Sengar, W Wang, J Bishay, S Cohen, SE Egan
The EMBO journal 18 (5), 1159-71, 1999
High-level JAG1 mRNA and protein predict poor outcome in breast cancer
BC Dickson, AM Mulligan, H Zhang, G Lockwood, FP O'Malley, SE Egan, ...
Modern pathology : an official journal of the United States and Canadian …, 2007
Activation of Notch signaling in human colon adenocarcinoma
M Reedijk, S Odorcic, H Zhang, R Chetty, C Tennert, BC Dickson, ...
International journal of oncology 33 (6), 1223-9, 2008
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
U Koch, TA Lacombe, D Holland, JL Bowman, BL Cohen, SE Egan, ...
Immunity 15 (2), 225-236, 2001
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts
AD Pfefferle, JI Herschkowitz, J Usary, JC Harrell, BT Spike, JR Adams, ...
Genome biology 14, 1-16, 2013
Notch signaling in mammary development and oncogenesis.
R Callahan, SE Egan
Journal of mammary gland biology and neoplasia 9 (2), 145-163, 2004
Expression of H-ras Correlates with Metastatic Potential: Evidence for Direct Regulation of the Metastatic Phenotype in 10T1/2 and NIH 3T3 Cells
SE Egan, GA McClarty, L Jarolim, JA Wright, I Spiro, G Hager, ...
Molecular and cellular biology 7 (2), 830-837, 1987
JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer.
M Reedijk, D Pinnaduwage, BC Dickson, AM Mulligan, H Zhang, SB Bull, ...
Breast cancer research and treatment 111 (3), 439-48, 2008
Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
HLSEE B. Cohen, A. Bashirullah, Lina Dagnino, C. Campbell, Bill Fisher, C. C ...
Nature Genetics 16 (3), 283-288, 1997
Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.
DT Denhardt, AH Greenberg, SE Egan, RT Hamilton, JA Wright
Oncogene 2 (1), 55-59, 1987
Notch receptors, partners and regulators: from conserved domains to powerful functions
SE Egan, B St-Pierre, CC Leow
Protein Modules in Signal Transduction, 273-324, 1998
Transformation by oncogenes encoding protein kinases induces the metastatic phenotype
SE Egan, JA Wright, L Jarolim, K Yanagihara, RH Bassin, AH Greenberg
Science 238 (4824), 202-205, 1987
Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation
JR Adams, K Xu, JC Liu, NM Agamez, AJ Loch, RG Wong, W Wang, ...
Cancer Research 71 (7), 2706-17, 2011
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches
JB Tan, K Xu, K Cretegny, I Visan, JS Yuan, SE Egan, CJ Guidos
Immunity 30 (2), 254-63, 2009
The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells.
M Hughes, N Dobric, IC Scott, L Su, M Starovic, B St-Pierre, SE Egan, ...
Developmental biology 271 (1), 26-37, 2004
Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis
N Singh, RA Phillips, NN Iscove, SE Egan
Experimental hematology 28 (5), 527-534, 2000
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