Rona Graham
Rona Graham
Assistant Professor, University of Sherbrooke
Verified email at usherbrooke.ca - Homepage
Title
Cited by
Cited by
Year
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
SE Andrew, YP Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, ...
Nature genetics 4 (4), 398-403, 1993
12301993
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
SE Andrew, YP Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, ...
Nature genetics 4 (4), 398-403, 1993
12241993
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow, J Van Raamsdonk, D Rogers, SH Coleman, RK Graham, ...
Human molecular genetics 12 (13), 1555-1567, 2003
7872003
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
YP Goldberg, DW Nicholson, DM Rasper, MA Kalchman, HB Koide, ...
Nature genetics 13 (4), 442-449, 1996
7191996
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ...
Cell 125 (6), 1179-1191, 2006
7142006
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407-1413, 2009
548*2009
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
M Saleh, JP Vaillancourt, RK Graham, M Huyck, SM Srinivasula, ...
Nature 429 (6987), 75-79, 2004
4852004
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
AJ Milnerwood, CM Gladding, MA Pouladi, AM Kaufman, RM Hines, ...
Neuron 65 (2), 178-190, 2010
4532010
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
MA Kalchman, HB Koide, K McCutcheon, RK Graham, K Nichol, ...
Nature genetics 16 (1), 44-53, 1997
4181997
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ...
Journal of Neuroscience 22 (18), 7862-7872, 2002
4142002
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
MA Kalchman, RK Graham, G Xia, HB Koide, JG Hodgson, KC Graham, ...
Journal of Biological Chemistry 271 (32), 19385-19394, 1996
4081996
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
EJ Slow, RK Graham, AP Osmand, RS Devon, G Lu, Y Deng, J Pearson, ...
Proceedings of the National Academy of Sciences 102 (32), 11402-11407, 2005
3152005
Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects
YP Goldberg, B Kremer, SE Andrew, J Theilmann, RK Graham, F Squitieri, ...
Nature genetics 5 (2), 174-179, 1993
2851993
Wild‐type huntingtin protects neurons from excitotoxicity
BR Leavitt, JM van Raamsdonk, J Shehadeh, H Fernandes, Z Murphy, ...
Journal of neurochemistry 96 (4), 1121-1129, 2006
2212006
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, ┼ PetersÚn, ...
Brain 132 (4), 919-932, 2009
1522009
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
P Guidetti, GP Bates, RK Graham, MR Hayden, BR Leavitt, ...
Neurobiology of disease 23 (1), 190-197, 2006
1512006
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
J Shehadeh, HB Fernandes, MMZ Mullins, RK Graham, BR Leavitt, ...
Neurobiology of disease 21 (2), 392-403, 2006
1432006
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ...
Human molecular genetics 17 (15), 2390-2404, 2008
1372008
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
T Ratovitski, M Gucek, H Jiang, E Chighladze, E Waldron, J D'Ambola, ...
Journal of Biological Chemistry 284 (16), 10855-10867, 2009
1362009
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
CE Wang, S Tydlacka, AL Orr, SH Yang, RK Graham, MR Hayden, S Li, ...
Human molecular genetics 17 (17), 2738-2751, 2008
1342008
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