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Cecilia Pozzi
Cecilia Pozzi
Verified email at unisi.it
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Year
Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine-and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections
B Liu, REL Trout, GH Chu, D McGarry, RW Jackson, JC Hamrick, ...
Journal of Medicinal Chemistry 63 (6), 2789-2801, 2019
2192019
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and …
JC Hamrick, JD Docquier, T Uehara, CL Myers, DA Six, CL Chatwin, ...
Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 01963-19, 2020
1502020
Structural insights into the ferroxidase site of ferritins from higher eukaryotes
I Bertini, D Lalli, S Mangani, C Pozzi, C Rosa, EC Theil, P Turano
Journal of the American Chemical Society 134 (14), 6169-6176, 2012
1092012
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase
D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ...
Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011
1032011
Iron binding to human heavy-chain ferritin
C Pozzi, F Di Pisa, C Bernacchioni, S Ciambellotti, P Turano, S Mangani
Acta Crystallographica Section D: Biological Crystallography 71 (9), 1909-1920, 2015
782015
Chemistry at the protein–mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo) Tris [(μ2-peroxo)] triiron (III) cluster
C Pozzi, S Ciambellotti, C Bernacchioni, F Di Pisa, S Mangani, P Turano
Proceedings of the National Academy of Sciences 114 (10), 2580-2585, 2017
752017
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design
F De Luca, M Benvenuti, F Carboni, C Pozzi, GM Rossolini, S Mangani, ...
Proceedings of the National Academy of Sciences 108 (45), 18424-18429, 2011
732011
SAR studies leading to the identification of a novel series of metallo-β-lactamase inhibitors for the treatment of carbapenem-resistant Enterobacteriaceae infections that …
S Leiris, A Coelho, J Castandet, M Bayet, C Lozano, J Bougnon, ...
ACS Infectious Diseases 5 (1), 131-140, 2018
542018
Time-lapse anomalous X-ray diffraction shows how Fe2+ substrate ions move through ferritin protein nanocages to oxidoreductase sites
C Pozzi, F Di Pisa, D Lalli, C Rosa, E Theil, P Turano, S Mangani
Acta Crystallographica Section D: Biological Crystallography 71 (4), 941-953, 2015
512015
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
C Borsari, R Luciani, C Pozzi, I Poehner, S Henrich, M Trande, ...
Journal of medicinal chemistry 59 (16), 7598-7616, 2016
492016
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
F Di Pisa, G Landi, L Dello Iacono, C Pozzi, C Borsari, S Ferrari, ...
Molecules 22 (3), 426, 2017
472017
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative
D Tondi, A Venturelli, R Bonnet, C Pozzi, BK Shoichet, MP Costi
Journal of medicinal chemistry 57 (12), 5449-5458, 2014
462014
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism
C Pozzi, S Ferrari, D Cortesi, R Luciani, RM Stroud, A Catalano, MP Costi, ...
Acta Crystallographica Section D: Biological Crystallography 68 (9), 1232-1241, 2012
392012
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of …
DT Davies, S Leiris, N Sprynski, J Castandet, C Lozano, J Bousquet, ...
ACS Infectious Diseases 6 (9), 2419-2430, 2020
362020
4-Amino-1, 2, 4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors
L Gavara, L Sevaille, F De Luca, P Mercuri, C Bebrone, G Feller, A Legru, ...
European Journal of Medicinal Chemistry 208, 112720, 2020
352020
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase
OMH Salo-Ahen, A Tochowicz, C Pozzi, D Cardinale, S Ferrari, Y Boum, ...
Journal of medicinal chemistry 58 (8), 3572-3581, 2015
312015
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
P Linciano, A Dawson, I Pöhner, DM Costa, MS Sa, A Cordeiro-da-Silva, ...
ACS omega 2 (9), 5666-5683, 2017
302017
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders
C Pozzi, F Di Pisa, M Benvenuti, S Mangani
JBIC Journal of Biological Inorganic Chemistry 23, 1219-1226, 2018
282018
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against …
DT Davies, S Leiris, M Zalacain, N Sprynski, J Castandet, J Bousquet, ...
Journal of Medicinal Chemistry 63 (24), 15802-15820, 2020
252020
Enhancement of benzothiazoles as pteridine reductase-1 inhibitors for the treatment of trypanosomatidic infections
P Linciano, C Pozzi, LD Iacono, F di Pisa, G Landi, A Bonucci, S Gul, ...
Journal of Medicinal Chemistry 62 (8), 3989-4012, 2019
252019
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