The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer E Kansanen, SM Kuosmanen, H Leinonen, AL Levonen Redox biology 1 (1), 45-49, 2013 | 1376 | 2013 |
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism E Kansanen, G Bonacci, FJ Schopfer, SM Kuosmanen, KI Tong, ... Journal of Biological Chemistry 286 (16), 14019-14027, 2011 | 222 | 2011 |
Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2 HK Jyrkkänen, S Kuosmanen, M Heinäniemi, H Laitinen, E Kansanen, ... Biochemical Journal 440 (2), 167-174, 2011 | 92 | 2011 |
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma P Pölönen, A Jawahar Deen, HM Leinonen, HK Jyrkkänen, S Kuosmanen, ... Oncogene 38 (50), 7473-7490, 2019 | 78 | 2019 |
MicroRNA profiling of pericardial fluid samples from patients with heart failure SM Kuosmanen, J Hartikainen, M Hippeläinen, H Kokki, AL Levonen, ... PloS one 10 (3), e0119646, 2015 | 78 | 2015 |
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation SM Kuosmanen, E Kansanen, MU Kaikkonen, V Sihvola, K Pulkkinen, ... Nucleic Acids Research 46 (3), 1124-1138, 2018 | 62 | 2018 |
MicroRNA profiling reveals distinct profiles for tissue-derived and cultured endothelial cells SM Kuosmanen, E Kansanen, V Sihvola, AL Levonen Scientific reports 7 (1), 10943, 2017 | 57 | 2017 |
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment HM Leinonen, AK Ruotsalainen, AM Määttä, HM Laitinen, ... Cancer research 72 (23), 6227-6235, 2012 | 56 | 2012 |
The effects of sequence variation on genome-wide NRF2 binding—new target genes and regulatory SNPs SM Kuosmanen, S Viitala, T Laitinen, M Peräkylä, P Pölönen, ... Nucleic acids research 44 (4), 1760-1775, 2016 | 43 | 2016 |
MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells SM Kuosmanen, V Sihvola, E Kansanen, MU Kaikkonen, AL Levonen Redox biology 18, 77-83, 2018 | 40 | 2018 |
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli S Linna-Kuosmanen, V Tomas Bosch, PR Moreau, M Bouvy-Liivrand, ... Cardiovascular research 117 (5), 1339-1357, 2021 | 34 | 2021 |
Nitro-oleic acid regulates endothelin signaling in human endothelial cells E Kansanen, SM Kuosmanen, AK Ruotsalainen, H Hynynen, AL Levonen Molecular Pharmacology 92 (4), 481-490, 2017 | 25 | 2017 |
The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol 1: 45–49 E Kansanen, SM Kuosmanen, H Leinonen, AL Levonen | 25 | 2013 |
Profiling of primary and mature miRNA expression in atherosclerosis-associated cell types PR Moreau, V Tomas Bosch, M Bouvy-Liivrand, K Õunap, T Örd, ... Arteriosclerosis, thrombosis, and vascular biology 41 (7), 2149-2167, 2021 | 19 | 2021 |
The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer, Redox Biol. 1 (2013) 45–49 E Kansanen, SM Kuosmanen, H Leinonen, AL Levonenn, A Levonen | 14 | |
Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility KK Patel, C Venkatesan, H Abdelhalim, S Zeeshan, Y Arima, ... Human genomics 17 (1), 47, 2023 | 11 | 2023 |
QClus: Robust and reliable preprocessing method for human heart snRNA-seq E Schmauch, J Ojanen, K Galani, J Jalkanen, M Hollmen, J Gunn, ... bioRxiv, 2022.10. 21.513315, 2022 | 2 | 2022 |
Simultaneous metabolomics analysis of atrial tissue, pericardial fluid and blood reveal novel metabolite signatures of the pathophysiology and biomarkers related to permanent … K Harju, T Tuomainen, M Lehtonen, O Karkkainen, S Linna-Kuosmanen, ... European Heart Journal 43 (Supplement_2), ehac544. 503, 2022 | 2 | 2022 |
Cardiovascular disease causes proinflammatory microvascular changes in the human right atrium S Linna-Kuosmanen, E Schmauch, K Galani, J Ojanen, C Boix, T Örd, ... | 2 | 2022 |
Single-cell dissection of live human hearts in ischemic heart disease and heart failure reveals cell-type-specific driver genes and pathways S Linna-Kuosmanen, E Schmauch, K Galani, CA Boix, L Hou, T Örd, ... BioRxiv, 2021.06. 23.449672, 2021 | 2 | 2021 |