Laura E Edgington-Mitchell
Laura E Edgington-Mitchell
Grimwade Research Fellow, University of Melbourne
Verified email at
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Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes
LE Edgington, AB Berger, G Blum, VE Albrow, MG Paulick, N Lineberry, ...
Nature medicine 15 (8), 967-973, 2009
Cathepsin B inhibition limits bone metastasis in breast cancer
NP Withana, G Blum, M Sameni, C Slaney, A Anbalagan, MB Olive, ...
Cancer research 72 (5), 1199-1209, 2012
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes
LE Edgington, M Verdoes, M Bogyo
Current opinion in chemical biology 15 (6), 798-805, 2011
Functional imaging of legumain in cancer using a new quenched activity-based probe
LE Edgington, M Verdoes, A Ortega, NP Withana, J Lee, S Syed, ...
Journal of the American Chemical Society 135 (1), 174-182, 2013
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ...
Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018
PD-1 inhibitory receptor downregulates asparaginyl endopeptidase and maintains Foxp3 transcription factor stability in induced regulatory T cells
C Stathopoulou, A Gangaplara, G Mallett, FA Flomerfelt, LP Liniany, ...
Immunity 49 (2), 247-263. e7, 2018
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity
G Blum, RM Weimer, LE Edgington, W Adams, M Bogyo
PLoS One 4 (7), e6374, 2009
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages
M Verdoes, LE Edgington, FA Scheeren, M Leyva, G Blum, K Weiskopf, ...
Chemistry & biology 19 (5), 619-628, 2012
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity
H Li, EL Ponder, M Verdoes, KH Asbjornsdottir, E Deu, LE Edgington, ...
Chemistry & biology 19 (12), 1535-1545, 2012
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis‐mediated therapy in a humanized death receptor mouse model
J Li, HC Hsu, PA Yang, Q Wu, H Li, LE Edgington, M Bogyo, RP Kimberly, ...
Arthritis & Rheumatism 64 (4), 1098-1109, 2012
An optimized activity-based probe for the study of caspase-6 activation
LE Edgington, BJ Van Raam, M Verdoes, C Wierschem, GS Salvesen, ...
Chemistry & biology 19 (3), 340-352, 2012
Myoepithelial cell‐specific expression of stefin A as a suppressor of early breast cancer invasion
HM Duivenvoorden, J Rautela, LE Edgington‐Mitchell, A Spurling, ...
The Journal of pathology 243 (4), 496-509, 2017
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer
LE Edgington-Mitchell, J Rautela, HM Duivenvoorden, KM Jayatilleke, ...
Oncotarget 6 (29), 27008, 2015
Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a 64Cu-Labeled Activity-Based Probe
G Ren, G Blum, M Verdoes, H Liu, S Syed, LE Edgington, O Gheysens, ...
PloS one 6 (11), e28029, 2011
Legumain induces oral cancer pain by biased agonism of protease-activated receptor-2
NH Tu, DD Jensen, BM Anderson, E Chen, NN Jimenez-Vargas, ...
Journal of Neuroscience 41 (1), 193-210, 2021
Lysosomal degradation products induce Coxiella burnetii virulence
P Newton, DR Thomas, SCO Reed, N Lau, B Xu, SY Ong, S Pasricha, ...
Proceedings of the National Academy of Sciences 117 (12), 6801-6810, 2020
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells
OV Razorenova, L Castellini, R Colavitti, LE Edgington, M Nicolau, ...
Molecular and cellular biology 34 (4), 739-751, 2014
Protease-activated receptors in health and disease
CJ Peach, LE Edgington-Mitchell, NW Bunnett, BL Schmidt
Physiological Reviews 103 (1), 717-785, 2023
Live cell imaging and profiling of cysteine cathepsin activity using a quenched activity-based probe
LE Edgington-Mitchell, M Bogyo, M Verdoes
Activity-Based Proteomics: Methods and Protocols, 145-159, 2017
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation
LE Edgington-Mitchell, N Barlow, L Aurelio, A Samha, M Szabo, ...
Bioorganic & medicinal chemistry letters 27 (2), 254-260, 2017
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