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Mei-Ling Han
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Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation
P Deo, SH Chow, ML Han, M Speir, C Huang, RB Schittenhelm, S Dhital, ...
Nature microbiology 5 (11), 1418-1427, 2020
1172020
Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae
SC Nang, FC Morris, MJ McDonald, ML Han, J Wang, RA Strugnell, ...
Journal of Antimicrobial Chemotherapy 73 (6), 1604-1610, 2018
812018
An “unlikely” pair: the antimicrobial synergy of polymyxin B in combination with the cystic fibrosis transmembrane conductance regulator drugs KALYDECO and ORKAMBI
EK Schneider, MAK Azad, ML Han, Q Zhou, J Wang, JX Huang, ...
ACS infectious diseases 2 (7), 478-488, 2016
812016
Eurifoloids A–R, Structurally Diverse Diterpenoids from Euphorbia neriifolia
JX Zhao, CP Liu, WY Qi, ML Han, YS Han, MA Wainberg, JM Yue
Journal of Natural Products 77 (10), 2224-2233, 2014
802014
Structure, function, and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria
T Velkov, A Gallardo-Godoy, JD Swarbrick, MAT Blaskovich, AG Elliott, ...
Cell chemical biology 25 (4), 380-391. e5, 2018
672018
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
KD Roberts, Y Zhu, MAK Azad, ML Han, J Wang, L Wang, HH Yu, ...
Nature communications 13 (1), 1625, 2022
612022
Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
ML Han, Y Zhu, DJ Creek, YW Lin, AD Gutu, P Hertzog, T Purcell, ...
MSystems 4 (1), 10.1128/msystems. 00149-18, 2019
592019
Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa
ML Han, Y Zhu, DJ Creek, YW Lin, D Anderson, HH Shen, B Tsuji, ...
Antimicrobial agents and chemotherapy 62 (6), 10.1128/aac. 02656-17, 2018
582018
Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance
ML Han, T Velkov, Y Zhu, KD Roberts, AP Le Brun, SH Chow, AD Gutu, ...
ACS chemical biology 13 (1), 121-130, 2018
562018
Walsucochinoids A and B: New Rearranged Limonoids from Walsura cochinchinensis
ML Han, H Zhang, SP Yang, JM Yue
Organic letters 14 (2), 486-489, 2012
532012
Walsucochinoids A and B: New Rearranged Limonoids from Walsura cochinchinensis
ML Han, H Zhang, SP Yang, JM Yue
Organic letters 14 (2), 486-489, 2012
532012
Emergence of high-level colistin resistance in an Acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS
D Deveson Lucas, B Crane, A Wright, ML Han, J Moffatt, D Bulach, ...
Antimicrobial Agents and Chemotherapy 62 (7), 10.1128/aac. 02442-17, 2018
522018
Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
MH Mahamad Maifiah, SE Cheah, MD Johnson, ML Han, JD Boyce, ...
Scientific reports 6 (1), 22287, 2016
522016
From breast cancer to antimicrobial: combating extremely resistant Gram-negative “superbugs” using novel combinations of polymyxin B with selective estrogen receptor modulators
MH Hussein, EK Schneider, AG Elliott, M Han, F Reyes-Ortega, F Morris, ...
Microbial Drug Resistance 23 (5), 640-650, 2017
512017
Trigoxyphins A−G: Diterpenes from Trigonostemon xyphophylloides
BD Lin, ML Han, YC Ji, HD Chen, SP Yang, S Zhang, MY Geng, JM Yue
Journal of natural products 73 (7), 1301-1305, 2010
502010
Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa
Y Zhu, T Czauderna, J Zhao, M Klapperstueck, MHM Maifiah, ML Han, ...
GigaScience 7 (4), giy021, 2018
482018
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance
Y Zhu, J Lu, ML Han, X Jiang, MAK Azad, NA Patil, YW Lin, J Zhao, Y Hu, ...
Advanced Science 7 (15), 2000704, 2020
452020
Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and-resistant Pseudomonas aeruginosa
M Hussein, ML Han, Y Zhu, Q Zhou, YW Lin, REW Hancock, D Hoyer, ...
Antimicrobial Agents and Chemotherapy 64 (1), 10.1128/aac. 01587-19, 2019
362019
11β-HSD1 Inhibitors from Walsura cochinchinensis
ML Han, Y Shen, GC Wang, Y Leng, H Zhang, JM Yue
Journal of Natural Products 76 (7), 1319-1327, 2013
362013
Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: a proof-of-concept study
YW Lin, RY Chang, GG Rao, B Jermain, ML Han, JX Zhao, K Chen, ...
Clinical Microbiology and Infection 26 (9), 1229-1235, 2020
342020
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