Jay (Jerome) Mettetal
Jay (Jerome) Mettetal
Director, AstraZeneca
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Cited by
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Stochastic switching as a survival strategy in fluctuating environments
M Acar, JT Mettetal, A Van Oudenaarden
Nature genetics 40 (4), 471-475, 2008
The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae
JT Mettetal, D Muzzey, C Gómez-Uribe, A van Oudenaarden
Science 319 (5862), 482-484, 2008
A systems-level analysis of perfect adaptation in yeast osmoregulation
D Muzzey, CA Gómez-Uribe, JT Mettetal, A van Oudenaarden
Cell 138 (1), 160-171, 2009
Impact of a five-dimensional framework on R&D productivity at AstraZeneca
P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ...
Nature reviews Drug discovery 17 (3), 167-181, 2018
Predicting stochastic gene expression dynamics in single cells
JT Mettetal, D Muzzey, JM Pedraza, EM Ozbudak, A Van Oudenaarden
Proceedings of the National Academy of Sciences 103 (19), 7304-7309, 2006
Heritable stochastic switching revealed by single-cell genealogy
BB Kaufmann, Q Yang, JT Mettetal, A van Oudenaarden
PLoS biology 5 (9), e239, 2007
Reactive metabolites: current and emerging risk and hazard assessments
RA Thompson, EM Isin, MO Ogese, JT Mettetal, DP Williams
Chemical Research in Toxicology 29 (4), 505-533, 2016
Anti-PCSK9 antibodies with pH dependent antigen binding
J Pons, JR Chabot, JFC Riggers, BC Gomes, H Liang, K Mayawala, ...
US Patent 9,029,515, 2015
Cellular asymmetry and individuality in directional sensing
A Samadani, J Mettetal, A Van Oudenaarden
Proceedings of the National Academy of Sciences 103 (31), 11549-11554, 2006
Application of microphysiological systems to enhance safety assessment in drug discovery
L Ewart, EM Dehne, K Fabre, S Gibbs, J Hickman, E Hornberg, ...
Annual review of pharmacology and toxicology 58, 65-82, 2018
Growth rate analysis and efficient experimental design for tumor xenograft studies: supplementary issue: array platform modeling and analysis (A)
G Hather, R Liu, S Bandi, J Mettetal, M Manfredi, WC Shyu, J Donelan, ...
Cancer informatics 13, CIN. S13974, 2014
Optimizing oncology therapeutics through quantitative translational and clinical pharmacology: challenges and opportunities
K Venkatakrishnan, LE Friberg, D Ouellet, JT Mettetal, A Stein, IF Trocóniz, ...
Clinical Pharmacology & Therapeutics 97 (1), 37-54, 2015
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
CW McAleer, A Pointon, CJ Long, RL Brighton, BD Wilkin, LR Bridges, ...
Scientific reports 9 (1), 1-14, 2019
Necessary noise
JT Mettetal, A van Oudenaarden
Science 317 (5837), 463-464, 2007
Preclinical QSP modeling in the pharmaceutical industry: an IQ consortium survey examining the current landscape
MJMA Nijsen, F Wu, L Bansal, E Bradshaw‐Pierce, JR Chan, BM Liederer, ...
CPT: pharmacometrics & systems pharmacology 7 (3), 135-146, 2018
Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape
E Schuck, T Bohnert, A Chakravarty, V Damian-Iordache, C Gibson, ...
The AAPS journal 17 (2), 462-473, 2015
Coarsening dynamics of a quasi–one-dimensional driven lattice gas
JT Mettetal, B Schmittmann, RKP Zia
EPL (Europhysics Letters) 58 (5), 653, 2002
Translational Exposure–Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib) Dose …
JJ Huck, M Zhang, J Mettetal, A Chakravarty, K Venkatakrishnan, X Zhou, ...
Molecular cancer therapeutics 13 (9), 2170-2183, 2014
Systems pharmacology to predict drug safety in drug development
MN Trame, K Biliouris, LJ Lesko, JT Mettetal
European Journal of Pharmaceutical Sciences 94, 93-95, 2016
Modeling and simulation approaches for cardiovascular function and their role in safety assessment
TA Collins, L Bergenholm, T Abdulla, JWT Yates, N Evans, MJ Chappell, ...
CPT: pharmacometrics & systems pharmacology 4 (3), 175-188, 2015
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