| Stochastic switching as a survival strategy in fluctuating environments M Acar, JT Mettetal, A Van Oudenaarden Nature genetics 40 (4), 471-475, 2008 | 1035 | 2008 |
| The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae JT Mettetal, D Muzzey, C Gómez-Uribe, A van Oudenaarden Science 319 (5862), 482-484, 2008 | 421 | 2008 |
| A systems-level analysis of perfect adaptation in yeast osmoregulation D Muzzey, CA Gómez-Uribe, JT Mettetal, A van Oudenaarden Cell 138 (1), 160-171, 2009 | 412 | 2009 |
| Impact of a five-dimensional framework on R&D productivity at AstraZeneca P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ... Nature reviews Drug discovery 17 (3), 167-181, 2018 | 375 | 2018 |
| Predicting stochastic gene expression dynamics in single cells JT Mettetal, D Muzzey, JM Pedraza, EM Ozbudak, A Van Oudenaarden Proceedings of the National Academy of Sciences 103 (19), 7304-7309, 2006 | 221 | 2006 |
| Reactive metabolites: current and emerging risk and hazard assessments RA Thompson, EM Isin, MO Ogese, JT Mettetal, DP Williams Chemical Research in Toxicology 29 (4), 505-533, 2016 | 154 | 2016 |
| Heritable stochastic switching revealed by single-cell genealogy BB Kaufmann, Q Yang, JT Mettetal, A van Oudenaarden PLoS biology 5 (9), e239, 2007 | 138 | 2007 |
| Anti-PCSK9 antibodies with pH dependent antigen binding J Pons, JR Chabot, JFC Riggers, BC Gomes, H Liang, K Mayawala, ... US Patent 9,029,515, 2015 | 131 | 2015 |
| Growth rate analysis and efficient experimental design for tumor xenograft studies: supplementary issue: array platform modeling and analysis (A) G Hather, R Liu, S Bandi, J Mettetal, M Manfredi, WC Shyu, J Donelan, ... Cancer informatics 13, CIN. S13974, 2014 | 128 | 2014 |
| Application of microphysiological systems to enhance safety assessment in drug discovery L Ewart, EM Dehne, K Fabre, S Gibbs, J Hickman, E Hornberg, ... Annual review of pharmacology and toxicology 58, 65-82, 2018 | 119 | 2018 |
| Cellular asymmetry and individuality in directional sensing A Samadani, J Mettetal, A Van Oudenaarden Proceedings of the National Academy of Sciences 103 (31), 11549-11554, 2006 | 103 | 2006 |
| Optimizing oncology therapeutics through quantitative translational and clinical pharmacology: challenges and opportunities K Venkatakrishnan, LE Friberg, D Ouellet, JT Mettetal, A Stein, IF Trocóniz, ... Clinical Pharmacology & Therapeutics 97 (1), 37-54, 2015 | 95 | 2015 |
| On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships CW McAleer, A Pointon, CJ Long, RL Brighton, BD Wilkin, LR Bridges, ... Scientific reports 9 (1), 9619, 2019 | 83 | 2019 |
| Preclinical QSP modeling in the pharmaceutical industry: an IQ consortium survey examining the current landscape MJMA Nijsen, F Wu, L Bansal, E Bradshaw‐Pierce, JR Chan, BM Liederer, ... CPT: pharmacometrics & systems pharmacology 7 (3), 135-146, 2018 | 59 | 2018 |
| Necessary noise JT Mettetal, A van Oudenaarden Science 317 (5837), 463-464, 2007 | 52 | 2007 |
| Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape E Schuck, T Bohnert, A Chakravarty, V Damian-Iordache, C Gibson, ... The AAPS journal 17, 462-473, 2015 | 50 | 2015 |
| Translational Exposure–Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib) JJ Huck, M Zhang, J Mettetal, A Chakravarty, K Venkatakrishnan, X Zhou, ... Molecular cancer therapeutics 13 (9), 2170-2183, 2014 | 41 | 2014 |
| Coarsening dynamics of a quasi–one-dimensional driven lattice gas JT Mettetal, B Schmittmann, RKP Zia Europhysics Letters 58 (5), 653, 2002 | 40 | 2002 |
| Systems pharmacology to predict drug safety in drug development MN Trame, K Biliouris, LJ Lesko, JT Mettetal European Journal of Pharmaceutical Sciences 94, 93-95, 2016 | 35 | 2016 |
| Systems pharmacology modeling of drug‐induced hyperbilirubinemia: differentiating hepatotoxicity and inhibition of enzymes/transporters K Yang, C Battista, JL Woodhead, SH Stahl, JT Mettetal, PB Watkins, ... Clinical Pharmacology & Therapeutics 101 (4), 501-509, 2017 | 32 | 2017 |
