Timothy J Kieffer
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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121-1133, 2014
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
TJ Kieffer, CH McIntosh, RA Pederson
Endocrinology 136 (8), 3585-3596, 1995
The glucagon-like peptides
TJ Kieffer, J Francis Habener
Endocrine reviews 20 (6), 876-913, 1999
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
KL Teff, SS Elliott, M Tschöp, TJ Kieffer, D Rader, M Heiman, ...
The Journal of Clinical Endocrinology & Metabolism 89 (6), 2963-2972, 2004
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.
DA Stoffers, TJ Kieffer, MA Hussain, DJ Drucker, S Bonner-Weir, ...
Diabetes 49 (5), 741-748, 2000
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
RM Seaberg, SR Smukler, TJ Kieffer, G Enikolopov, Z Asghar, ...
Nature biotechnology 22 (9), 1115-1124, 2004
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic β-cells
TJ Kieffer, RS Heller, CA Leech, GG Holz, JF Habener
Diabetes 46 (6), 1087-1093, 1997
Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
A Rezania, JE Bruin, MJ Riedel, M Mojibian, A Asadi, J Xu, R Gauvin, ...
Diabetes 61 (8), 2016-2029, 2012
The adipoinsular axis: effects of leptin on pancreatic β-cells
TJ Kieffer, JF Habener
American Journal of Physiology-Endocrinology and Metabolism 278 (1), E1-E14, 2000
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
AE Mehran, NM Templeman, GS Brigidi, GE Lim, KY Chu, X Hu, ...
Cell metabolism 16 (6), 723-737, 2012
Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus
J Seufert, TJ Kieffer, CA Leech, GG Holz, W Moritz, C Ricordi, JF Habener
The Journal of clinical endocrinology & metabolism 84 (2), 670-676, 1999
Leptin receptors expressed on pancreatic β-cells
TJ Kieffer, RS Heller, JF Habener
Biochemical and biophysical research communications 224 (2), 522-527, 1996
Glucose-dependent insulin release from genetically engineered K cells
AT Cheung, B Dayanandan, JT Lewis, GS Korbutt, RV Rajotte, ...
Science 290 (5498), 1959-1962, 2000
Enrichment of human embryonic stem cell-derived NKX6. 1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo
A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer
Stem cells 31 (11), 2432-2442, 2013
Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents
S Stock, P Leichner, ACK Wong, MA Ghatei, TJ Kieffer, SR Bloom, ...
The Journal of Clinical Endocrinology & Metabolism 90 (4), 2161-2168, 2005
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
J Seufert, TJ Kieffer, JF Habener
Proceedings of the National Academy of Sciences 96 (2), 674-679, 1999
Functional GIP receptors are present on adipocytes
RGC Yip, MO Boylan, TJ Kieffer, MM Wolfe
Endocrinology 139 (9), 4004-4007, 1998
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
FC Lynn, N Pamir, EHC Ng, CHS McIntosh, TJ Kieffer, RA Pederson
Diabetes 50 (5), 1004-1011, 2001
Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing α-cells of the rat endocrine pancreas
RS Heller, TJ Kieffer, JF Habener
Diabetes 46 (5), 785-791, 1997
The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis
SD Covey, RD Wideman, C McDonald, S Unniappan, F Huynh, A Asadi, ...
Cell metabolism 4 (4), 291-302, 2006
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