Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions VS Ayyar, S Sukumaran Journal of pharmacokinetics and pharmacodynamics 48, 321-338, 2021 | 62 | 2021 |
Model‐based cellular kinetic analysis of chimeric antigen receptor‐T cells in humans C Liu, VS Ayyar, X Zheng, W Chen, S Zheng, H Mody, W Wang, D Heald, ... Clinical Pharmacology & Therapeutics 109 (3), 716-727, 2021 | 54 | 2021 |
Transitioning from basic toward systems pharmacodynamic models: lessons from corticosteroids VS Ayyar, WJ Jusko Pharmacological reviews 72 (2), 414-438, 2020 | 34 | 2020 |
Quantitative tissue‐specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids VS Ayyar, RR Almon, WJ Jusko, DC DuBois Physiological Reports 3 (6), e12382, 2015 | 34 | 2015 |
Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism VS Ayyar, RR Almon, DC DuBois, S Sukumaran, J Qu, WJ Jusko Journal of proteomics 160, 84-105, 2017 | 27 | 2017 |
Pharmacokinetic and pharmacodynamic modeling of siRNA therapeutics–a minireview JY Jeon, VS Ayyar, A Mitra Pharmaceutical research 39 (8), 1749-1759, 2022 | 26 | 2022 |
Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals X Wang, DC DuBois, S Sukumaran, V Ayyar, WJ Jusko, RR Almon Diabetes, metabolic syndrome and obesity: targets and therapy, 531-541, 2014 | 25 | 2014 |
Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression VS Ayyar, DC DuBois, T Nakamura, RR Almon, WJ Jusko Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257527, 2019 | 23 | 2019 |
Clarification of contraceptive drug pharmacokinetics in obesity WJ Jusko Contraception 95 (1), 10-16, 2017 | 23 | 2017 |
Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of N-Acetylgalactosamine–Conjugated small interfering RNA disposition and gene silencing in … VS Ayyar, D Song, S Zheng, T Carpenter, DL Heald Journal of Pharmacology and Experimental Therapeutics 379 (2), 134-146, 2021 | 22 | 2021 |
Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat VS Ayyar, D Song, DC DuBois, RR Almon, WJ Jusko Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257519, 2019 | 21 | 2019 |
Mechanistic Multi—Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics VS Ayyar, DC DuBois, RR Almon, WJ Jusko Journal of Pharmacology and Experimental Therapeutics 363 (1), 45-57, 2017 | 17 | 2017 |
Indirect pharmacodynamic models for responses with circadian removal VS Ayyar, W Krzyzanski, WJ Jusko Journal of pharmacokinetics and pharmacodynamics 46, 89-101, 2019 | 12 | 2019 |
Seeking nonspecific binding: assessing the reliability of tissue dilutions for calculating fraction unbound WJ Jusko, EAG Molins, VS Ayyar Drug Metabolism and Disposition 48 (10), 894-902, 2020 | 11 | 2020 |
Modeling Corticosteroid Pharmacokinetics & Pharmacodynamics, Part III: Estrous Cycle-and Estrogen Receptor-Dependent Antagonism of GILZ Enhancement by Corticosteroids VS Ayyar, DC DuBois, RR Almon, WJ Jusko Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257543, 2019 | 11 | 2019 |
Modeling corticosteroid pharmacogenomics and proteomics in rat liver VS Ayyar, S Sukumaran, DC DuBois, RR Almon, WJ Jusko Journal of Pharmacology and Experimental Therapeutics 367 (1), 168-183, 2018 | 9 | 2018 |
Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver VS Ayyar, S Sukumaran, DC DuBois, RR Almon, J Qu, WJ Jusko Journal of pharmacokinetics and pharmacodynamics 45, 557-575, 2018 | 7 | 2018 |
CPT: Pharmacometrics & Systems Pharmacology–inception, maturation, and future vision KR Yeo, S Hennig, S Krishnaswami, N Strydom, VS Ayyar, J French, ... CPT: Pharmacometrics & Systems Pharmacology 10 (7), 649, 2021 | 6 | 2021 |
Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor VS Ayyar, P Jaiprasart, B Geist, Z Huang Devine, M Case, A Hazra, ... British Journal of Pharmacology 178 (19), 3943-3958, 2021 | 4 | 2021 |
ATLAS mPBPK: a MATLAb‐based tool for modeling and Simulation of minimal Physiologically Based PharmacoKinetic models PD Mavroudis, VS Ayyar, WJ Jusko CPT: pharmacometrics & systems pharmacology, 2019 | 3 | 2019 |