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Vivaswath S. Ayyar
Vivaswath S. Ayyar
Janssen Research & Development; University at Buffalo
Verified email at buffalo.edu
Title
Cited by
Cited by
Year
Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions
VS Ayyar, S Sukumaran
Journal of pharmacokinetics and pharmacodynamics 48, 321-338, 2021
622021
Model‐based cellular kinetic analysis of chimeric antigen receptor‐T cells in humans
C Liu, VS Ayyar, X Zheng, W Chen, S Zheng, H Mody, W Wang, D Heald, ...
Clinical Pharmacology & Therapeutics 109 (3), 716-727, 2021
542021
Transitioning from basic toward systems pharmacodynamic models: lessons from corticosteroids
VS Ayyar, WJ Jusko
Pharmacological reviews 72 (2), 414-438, 2020
342020
Quantitative tissue‐specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids
VS Ayyar, RR Almon, WJ Jusko, DC DuBois
Physiological Reports 3 (6), e12382, 2015
342015
Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism
VS Ayyar, RR Almon, DC DuBois, S Sukumaran, J Qu, WJ Jusko
Journal of proteomics 160, 84-105, 2017
272017
Pharmacokinetic and pharmacodynamic modeling of siRNA therapeutics–a minireview
JY Jeon, VS Ayyar, A Mitra
Pharmaceutical research 39 (8), 1749-1759, 2022
262022
Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals
X Wang, DC DuBois, S Sukumaran, V Ayyar, WJ Jusko, RR Almon
Diabetes, metabolic syndrome and obesity: targets and therapy, 531-541, 2014
252014
Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression
VS Ayyar, DC DuBois, T Nakamura, RR Almon, WJ Jusko
Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257527, 2019
232019
Clarification of contraceptive drug pharmacokinetics in obesity
WJ Jusko
Contraception 95 (1), 10-16, 2017
232017
Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of N-Acetylgalactosamine–Conjugated small interfering RNA disposition and gene silencing in …
VS Ayyar, D Song, S Zheng, T Carpenter, DL Heald
Journal of Pharmacology and Experimental Therapeutics 379 (2), 134-146, 2021
222021
Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat
VS Ayyar, D Song, DC DuBois, RR Almon, WJ Jusko
Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257519, 2019
212019
Mechanistic Multi—Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics
VS Ayyar, DC DuBois, RR Almon, WJ Jusko
Journal of Pharmacology and Experimental Therapeutics 363 (1), 45-57, 2017
172017
Indirect pharmacodynamic models for responses with circadian removal
VS Ayyar, W Krzyzanski, WJ Jusko
Journal of pharmacokinetics and pharmacodynamics 46, 89-101, 2019
122019
Seeking nonspecific binding: assessing the reliability of tissue dilutions for calculating fraction unbound
WJ Jusko, EAG Molins, VS Ayyar
Drug Metabolism and Disposition 48 (10), 894-902, 2020
112020
Modeling Corticosteroid Pharmacokinetics & Pharmacodynamics, Part III: Estrous Cycle-and Estrogen Receptor-Dependent Antagonism of GILZ Enhancement by Corticosteroids
VS Ayyar, DC DuBois, RR Almon, WJ Jusko
Journal of Pharmacology and Experimental Therapeutics, jpet. 119.257543, 2019
112019
Modeling corticosteroid pharmacogenomics and proteomics in rat liver
VS Ayyar, S Sukumaran, DC DuBois, RR Almon, WJ Jusko
Journal of Pharmacology and Experimental Therapeutics 367 (1), 168-183, 2018
92018
Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver
VS Ayyar, S Sukumaran, DC DuBois, RR Almon, J Qu, WJ Jusko
Journal of pharmacokinetics and pharmacodynamics 45, 557-575, 2018
72018
CPT: Pharmacometrics & Systems Pharmacology–inception, maturation, and future vision
KR Yeo, S Hennig, S Krishnaswami, N Strydom, VS Ayyar, J French, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (7), 649, 2021
62021
Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor
VS Ayyar, P Jaiprasart, B Geist, Z Huang Devine, M Case, A Hazra, ...
British Journal of Pharmacology 178 (19), 3943-3958, 2021
42021
ATLAS mPBPK: a MATLAb‐based tool for modeling and Simulation of minimal Physiologically Based PharmacoKinetic models
PD Mavroudis, VS Ayyar, WJ Jusko
CPT: pharmacometrics & systems pharmacology, 2019
32019
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