| Dysregulation of the mevalonate pathway promotes transformation JW Clendening, A Pandyra, PC Boutros, SE Ghamrasni, F Khosravi, ... Proceedings of the National Academy of Sciences 107 (34), 15051-15056, 2010 | 434 | 2010 |
| Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer L Li, MJ Halaby, A Hakem, R Cardoso, S El Ghamrasni, S Harding, ... Journal of Experimental Medicine 207 (5), 983-997, 2010 | 135 | 2010 |
| Systemic ceramide accumulation leads to severe and varied pathological consequences AM Alayoubi, JCM Wang, BCY Au, S Carpentier, V Garcia, S Dworski, ... EMBO molecular medicine 5 (6), 827-842, 2013 | 111 | 2013 |
| RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks M Bohgaki, T Bohgaki, S El Ghamrasni, T Srikumar, G Maire, S Panier, ... Proceedings of the National Academy of Sciences 110 (52), 20982-20987, 2013 | 104 | 2013 |
| Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity SY Cindy Yang, SC Lien, BX Wang, DL Clouthier, Y Hanna, I Cirlan, ... Nature communications 12 (1), 5137, 2021 | 70 | 2021 |
| Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape JP Bruce, KF To, VWY Lui, GTY Chung, YY Chan, CM Tsang, KY Yip, ... Nature communications 12 (1), 4193, 2021 | 62 | 2021 |
| RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors PS Patel, KJ Abraham, KKN Guturi, MJ Halaby, Z Khan, L Palomero, B Ho, ... The Journal of clinical investigation 131 (3), 2021 | 47 | 2021 |
| RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation KKN Guturi, M Bohgaki, T Bohgaki, T Srikumar, D Ng, R Kumareswaran, ... Nature communications 7 (1), 12638, 2016 | 46 | 2016 |
| Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer S El Ghamrasni, A Pamidi, MJ Halaby, M Bohgaki, R Cardoso, L Li, ... PLoS genetics 7 (5), e1001385, 2011 | 24 | 2011 |
| Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis MJ Halaby, A Hakem, L Li, S El Ghamrasni, S Venkatesan, PM Hande, ... PLoS genetics 9 (1), e1003259, 2013 | 23 | 2013 |
| Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis A Hakem, S El Ghamrasni, G Maire, B Lemmers, J Karaskova, ... Blood, The Journal of the American Society of Hematology 119 (15), 3495-3502, 2012 | 22 | 2012 |
| The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor–resistant ER+ breast cancer with mitotic aberrations I Soria-Bretones, KL Thu, J Silvester, J Cruickshank, S El Ghamrasni, ... Science Advances 8 (36), eabq4293, 2022 | 18 | 2022 |
| Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression S El Ghamrasni, R Cardoso, MJ Halaby, D Zeegers, S Harding, ... Oncogene 34 (14), 1780-1789, 2015 | 18 | 2015 |
| IDH2 and TET2 mutations synergize to modulate T follicular helper cell functional interaction with the AITL microenvironment J Leca, F Lemonnier, C Meydan, J Foox, S El Ghamrasni, DL Mboumba, ... Cancer Cell 41 (2), 323-339. e10, 2023 | 16 | 2023 |
| Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis, and promotes breast cancer E Langille, KN Al-Zahrani, Z Ma, M Liang, L Uuskula-Reimand, R Espin, ... Cancer discovery 12 (12), 2930-2953, 2022 | 14 | 2022 |
| Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor R Quevedo, A Spreafico, J Bruce, A Danesh, S El Ghamrasni, A Giesler, ... Genome Medicine 12, 1-15, 2020 | 12 | 2020 |
| Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation S El Ghamrasni, R Cardoso, L Li, KKN Guturi, VA Bjerregaard, Y Liu, ... Oncogene 35 (37), 4836-4845, 2016 | 12 | 2016 |
| Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer S El Ghamrasni, R Quevedo, J Hawley, P Mazrooei, Y Hanna, I Cirlan, ... Molecular Cancer Research 20 (1), 102-113, 2022 | 3 | 2022 |
| Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality P Lin, C Lourenco, J Cruickshank, L Palomero, JE van Leeuwen, ... Cancer Research 83 (24), 4015-4029, 2023 | 2 | 2023 |
| RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells R Krishnan, M Lapierre, B Gautreau, KCJ Nixon, S El Ghamrasni, ... Nucleic Acids Research 51 (19), 10484-10505, 2023 | 2 | 2023 |
Linda Z. PennSenior Scientist, Princess Margaret Cancer Centre, Toronto, Ontario CanadaVerified email at uhnresearch.ca
