In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ... Science 351 (6271), 403-407, 2016 | 1322 | 2016 |
Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy JW McGreevy, CH Hakim, MA McIntosh, D Duan Disease models & mechanisms 8 (3), 195-213, 2015 | 519 | 2015 |
Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy JH Shin, X Pan, CH Hakim, HT Yang, Y Yue, K Zhang, RL Terjung, ... Molecular therapy 21 (4), 750-757, 2013 | 150 | 2013 |
Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus Y Yue, X Pan, CH Hakim, K Kodippili, K Zhang, JH Shin, HT Yang, ... Human molecular genetics 24 (20), 5880-5890, 2015 | 125 | 2015 |
Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin‐null mice D Li, Y Yue, Y Lai, CH Hakim, D Duan The Journal of pathology 223 (1), 88-98, 2011 | 112 | 2011 |
A five-repeat micro-dystrophin gene ameliorated dystrophic phenotype in the severe DBA/2J-mdx model of Duchenne muscular dystrophy CH Hakim, NB Wasala, X Pan, K Kodippili, Y Yue, K Zhang, G Yao, ... Molecular Therapy-Methods & Clinical Development 6, 216-230, 2017 | 105 | 2017 |
AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice CH Hakim, NB Wasala, CE Nelson, LP Wasala, Y Yue, JA Louderman, ... JCI insight 3 (23), 2018 | 94 | 2018 |
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice CH Hakim, NB Wasala, D Duan JoVE (Journal of Visualized Experiments), e50183, 2013 | 90 | 2013 |
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models CH Hakim, SRP Kumar, DO Pérez-López, NB Wasala, D Zhang, Y Yue, ... Nature communications 12 (1), 6769, 2021 | 86 | 2021 |
Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy Y Zhang, Y Yue, L Li, CH Hakim, K Zhang, GD Thomas, D Duan Human molecular genetics 22 (18), 3720-3729, 2013 | 85 | 2013 |
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2-to 20-mo-old mdx mice CH Hakim, RW Grange, D Duan Journal of applied physiology 110 (6), 1656-1663, 2011 | 84 | 2011 |
Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction JH Shin, CH Hakim, K Zhang, D Duan Muscle & nerve 43 (2), 283-286, 2011 | 74 | 2011 |
Dual AAV Gene Therapy for Duchenne Muscular Dystrophy with a 7-kb Mini-Dystrophin Gene in the Canine Model K Kodippili, CH Hakim, X Pan, HT Yang, Y Yue, Y Zhang, JH Shin, ... Human gene therapy 29 (3), 299-311, 2018 | 72 | 2018 |
Monitoring murine skeletal muscle function for muscle gene therapy CH Hakim, D Li, D Duan Muscle Gene Therapy: Methods and Protocols, 75-89, 2011 | 70 | 2011 |
Connexin isoform expression in smooth muscle cells and endothelial cells of hamster cheek pouch arterioles and retractor feed arteries CH Hakim, WF Jackson, SS Segal Microcirculation 15 (6), 503-514, 2008 | 65 | 2008 |
Dystrophin contains multiple independent membrane-binding domains J Zhao, K Kodippili, Y Yue, CH Hakim, L Wasala, X Pan, K Zhang, ... Human molecular genetics 25 (17), 3647-3653, 2016 | 59 | 2016 |
AAV9 edits muscle stem cells in normal and dystrophic adult mice ME Nance, R Shi, CH Hakim, NB Wasala, Y Yue, X Pan, T Zhang, ... Molecular Therapy 27 (9), 1568-1585, 2019 | 58 | 2019 |
Gender differences in contractile and passive properties of mdx extensor digitorum longus muscle CH Hakim, D Duan Muscle & nerve 45 (2), 250-256, 2012 | 42 | 2012 |
Dystrophin deficiency compromises force production of the extensor carpi ulnaris muscle in the canine model of Duchenne muscular dystrophy HT Yang, JH Shin, CH Hakim, X Pan, RL Terjung, D Duan Public Library of Science 7 (9), e44438, 2012 | 35 | 2012 |
Nanotherapy for Duchenne muscular dystrophy ME Nance, CH Hakim, NN Yang, D Duan Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 10 (2 …, 2018 | 34 | 2018 |