| Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information I Sushko, S Novotarskyi, R Körner, AK Pandey, M Rupp, W Teetz, ... Journal of computer-aided molecular design 25 (6), 533-554, 2011 | 269 | 2011 |
| Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P LD Hughes, DS Palmer, F Nigsch, JBO Mitchell Journal of chemical information and modeling 48 (1), 220-232, 2008 | 157 | 2008 |
| Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization F Nigsch, A Bender, B van Buuren, J Tissen, E Nigsch, JBO Mitchell Journal of chemical information and modeling 46 (6), 2412-2422, 2006 | 143 | 2006 |
| Rethinking molecular similarity: comparing compounds on the basis of biological activity PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ... ACS chemical biology 7 (8), 1399-1409, 2012 | 113 | 2012 |
| High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions D Hoepfner, SB Helliwell, H Sadlish, S Schuierer, I Filipuzzi, S Brachat, ... Microbiological research 169 (2-3), 107-120, 2014 | 111 | 2014 |
| The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size L Planas-Paz, V Orsini, L Boulter, D Calabrese, M Pikiolek, F Nigsch, ... Nature cell biology 18 (5), 467-479, 2016 | 107 | 2016 |
| Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics F Nigsch, A Bender, JL Jenkins, JBO Mitchell Journal of chemical information and modeling 48 (12), 2313-2325, 2008 | 102 | 2008 |
| Total synthesis of (+)-crocacin D LC Dias, LG de Oliveira, JD Vilcachagua, F Nigsch The Journal of organic chemistry 70 (6), 2225-2234, 2005 | 85 | 2005 |
| Computational toxicology: an overview of the sources of data and of modelling methods F Nigsch, NJM Macaluso, JBO Mitchell, D Zmuidinavicius Expert Opinion on Drug Metabolism & Toxicology 5 (1), 1-14, 2009 | 69 | 2009 |
| Predicting the mechanism of phospholipidosis R Lowe, HY Mussa, F Nigsch, RC Glen, JBO Mitchell Journal of cheminformatics 4 (1), 2, 2012 | 57 | 2012 |
| Recent trends and observations in the design of high-quality screening collections S Renner, M Popov, A Schuffenhauer, HJ Roth, W Breitenstein, ... Future medicinal chemistry 3 (6), 751-766, 2011 | 54 | 2011 |
| Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia C Dafflon, VJ Craig, H Mereau, J Gräsel, BS Engstler, G Hoffman, ... Leukemia 31 (6), 1269-1277, 2017 | 40 | 2017 |
| A novel hybrid ultrafast shape descriptor method for use in virtual screening EO Cannon, F Nigsch, JBO Mitchell Chemistry Central Journal 2 (1), 3, 2008 | 37 | 2008 |
| Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy C Potting, C Crochemore, F Moretti, F Nigsch, I Schmidt, C Manneville, ... Proceedings of the National Academy of Sciences 115 (2), E180-E189, 2018 | 36 | 2018 |
| Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction NM O'Boyle, DS Palmer, F Nigsch, JBO Mitchell Chemistry Central Journal 2 (1), 21, 2008 | 33 | 2008 |
| The RSPO-LGR4 L Planas-Paz, V Orsini, L Boulter, D Calabrese, M Pikiolek, F Nigsch, ... 5–ZNRF3/RNF43 module controls liver zonation and size 5, 467-479, 2016 | 32 | 2016 |
| Computational methods for early predictive safety assessment from biological and chemical data F Nigsch, E Lounkine, P McCarren, B Cornett, M Glick, K Azzaoui, ... Expert opinion on drug metabolism & toxicology 7 (12), 1497-1511, 2011 | 31 | 2011 |
| A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi A Voorberg-van der Wel, G Roma, DK Gupta, S Schuierer, F Nigsch, ... Elife 6, e29605, 2017 | 29 | 2017 |
| Analysis of iterative screening with stepwise compound selection based on Novartis in-house HTS data S Paricharak, AP IJzerman, A Bender, F Nigsch ACS chemical biology 11 (5), 1255-1264, 2016 | 28 | 2016 |
| YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury L Planas-Paz, T Sun, M Pikiolek, NR Cochran, S Bergling, V Orsini, ... Cell Stem Cell 25 (1), 39-53. e10, 2019 | 27 | 2019 |
Jeremy L. JenkinsHead, Data Science, Novartis Institutes for BioMedical ResearchVerified email at novartis.com
