leila akkari
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CSF-1R inhibition alters macrophage polarization and blocks glioma progression
SM Pyonteck, L Akkari, AJ Schuhmacher, RL Bowman, L Sevenich, ...
Nature medicine 19 (10), 1264-1272, 2013
Non-cell-autonomous tumor suppression by p53
A Lujambio, L Akkari, J Simon, D Grace, DF Tschaharganeh, JE Bolden, ...
Cell 153 (2), 449-460, 2013
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
DF Quail, RL Bowman, L Akkari, ML Quick, AJ Schuhmacher, JT Huse, ...
Science 352 (6288), aad3018, 2016
Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies
RL Bowman, F Klemm, L Akkari, SM Pyonteck, L Sevenich, DF Quail, ...
Cell reports 17 (9), 2445-2459, 2016
Inducing and exploiting vulnerabilities for the treatment of liver cancer
C Wang, S Vegna, H Jin, B Benedict, C Lieftink, C Ramirez, ...
Nature 574 (7777), 268-272, 2019
Metabolic origins of spatial organization in the tumor microenvironment
C Carmona-Fontaine, M Deforet, L Akkari, CB Thompson, JA Joyce, ...
Proceedings of the National Academy of Sciences 114 (11), 2934-2939, 2017
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
DF Quail, OC Olson, P Bhardwaj, LA Walsh, L Akkari, ML Quick, IC Chen, ...
Nature cell biology 19 (8), 974-987, 2017
EGFR activation limits the response of liver cancer to lenvatinib
H Jin, Y Shi, Y Lv, S Yuan, CFA Ramirez, C Lieftink, L Wang, S Wang, ...
Nature 595 (7869), 730-734, 2021
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance
L Akkari, RL Bowman, J Tessier, F Klemm, SM Handgraaf, M de Groot, ...
Science translational medicine 12 (552), eaaw7843, 2020
Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide
W Wick, P Roth, C Hartmann, P Hau, M Nakamura, F Stockhammer, ...
Neuro-oncology 18 (11), 1529-1537, 2016
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
D Yan, J Kowal, L Akkari, AJ Schuhmacher, JT Huse, BL West, JA Joyce
Oncogene 36 (43), 6049-6058, 2017
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
C Carmona-Fontaine, V Bucci, L Akkari, M Deforet, JA Joyce, JB Xavier
Proceedings of the National Academy of Sciences 110 (48), 19402-19407, 2013
mTOR regulates phagosome and entotic vacuole fission
M Krajcovic, S Krishna, L Akkari, JA Joyce, M Overholtzer
Molecular biology of the cell 24 (23), 3736-3745, 2013
Single-cell spatial immune landscapes of primary and metastatic brain tumours
E Karimi, MW Yu, SM Maritan, LJM Perus, M Rezanejad, M Sorin, ...
Nature 614 (7948), 555-563, 2023
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix
L Akkari, V Gocheva, JC Kester, KE Hunter, ML Quick, L Sevenich, ...
Genes & development 28 (19), 2134-2150, 2014
The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase
VR Sanghvi, J Leibold, M Mina, P Mohan, M Berishaj, Z Li, MM Miele, ...
Cell 178 (4), 807-819. e21, 2019
A carbon nanotube optical reporter maps endolysosomal lipid flux
PV Jena, D Roxbury, TV Galassi, L Akkari, CP Horoszko, DB Iaea, ...
ACS nano 11 (11), 10689-10703, 2017
Macrophages at the interface of the co-evolving cancer ecosystem
DJ Kloosterman, L Akkari
Cell 186 (8), 1627-1651, 2023
Innate immune cells in the tumor microenvironment
MO Li, N Wolf, DH Raulet, L Akkari, MJ Pittet, PC Rodriguez, RN Kaplan, ...
Cancer Cell 39 (6), 725-729, 2021
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors
L Akkari, D Grégoire, N Floc’h, M Moreau, C Hernandez, Y Simonin, ...
Journal of hepatology 57 (5), 1021-1028, 2012
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