Zachary Steinhart
Zachary Steinhart
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Verified email at mail.utoronto.ca
Title
Cited by
Cited by
Year
High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ...
Cell 163 (6), 1515-1526, 2015
7352015
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ...
Nature medicine 23 (1), 60-68, 2017
1462017
Wnt signaling in development and tissue homeostasis
Z Steinhart, S Angers
Development 145 (11), dev146589, 2018
912018
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay
MV Gammons, TJ Rutherford, Z Steinhart, S Angers, M Bienz
Journal of cell science 129 (20), 3892-3902, 2016
392016
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins
I Cervenka, J Valnohova, O Bernatik, J Harnos, M Radsetoulal, K Sedova, ...
Proceedings of the National Academy of Sciences 113 (33), 9304-9309, 2016
362016
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
Cell reports 27 (3), 971-986. e9, 2019
192019
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
Y Tao, M Mis, L Blazer, MU Jnr, Z Steinhart, R Chidiac, E Kubarakos, ...
Elife 8, e46134, 2019
62019
A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
Z Pavlovic, JJ Adams, LL Blazer, AK Gakhal, N Jarvik, Z Steinhart, ...
MAbs 10 (8), 1157-1167, 2018
62018
Systematic discovery and classification of human cell line essential genes
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, S Angers, ...
bioRxiv, 015412, 2015
42015
IPO11 mediates βcatenin nuclear import in a subset of colorectal cancersIPO11 mediates βcatenin nuclear import in cancer
M Mis, S O’Brien, Z Steinhart, S Lin, T Hart, J Moffat, S Angers
The Journal of cell biology 219 (2), 2020
32020
Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ...
Nature medicine 23 (11), 1384, 2017
22017
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation
W Ma, M Chen, H Kang, Z Steinhart, S Angers, X He, MW Kirschner
Proceedings of the National Academy of Sciences, 2020
12020
Abstract IA13: Inhibiting the Wnt pathway with selective anti-Frizzled synthetic antibodies
Z Steinhart, T Hart, S Sidhu, J Moffat, S Angers
Molecular Cancer Research 14 (4 Supplement), IA13-IA13, 2016
12016
A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer
Z Steinhart, T Hart, M Chandrashekhar, Z Pavlovic, M Robitaille, X Wang, ...
bioRxiv, 041996, 2016
12016
Genome-wide CRISPR Screens to Uncover Novel Therapeutic Targets in Wnt-β-catenin Driven Gastrointestinal Cancers
Z Steinhart
2019
SPOT-009 Identification of novel hippo pathway regulators using a genome wide CRISPR screen
S Sen, S Mis, Z Steinhart, S Angers, L Attisano
ESMO Open 3 (Suppl 2), A19-A19, 2018
2018
A Genome-Wide CRISPR-Cas9 Screen Identifies Importin-β11 as a Required Factor for β-catenin Signaling in Colon Cancer
M Mis, Z Steinhart, S Angers
The FASEB Journal 32 (1_supplement), 804.11-804.11, 2018
2018
Identification of FZD5 as Genetic Vulnerability in RNF43 Mutant Cancer
Z Steinhart, Z Pavlovic, M Chandrashekhar, K Mascall, T Hart, X Wang, ...
The FASEB Journal 32 (1_supplement), 804.31-804.31, 2018
2018
The functional genomic circuitry of human glioblastoma stem cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
2018
Frizzled protein-binding agents and methods of use thereof
G Pan, J Moffat, S Sidhu, S Angers, Z Steinhart, X Wang
2017
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