Zachary Steinhart
Zachary Steinhart
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Verified email at mail.utoronto.ca
TitleCited byYear
High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ...
Cell 163 (6), 1515-1526, 2015
5322015
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ...
Nature medicine 23 (1), 60, 2017
1032017
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins
I Cervenka, J Valnohova, O Bernatik, J Harnos, M Radsetoulal, K Sedova, ...
Proceedings of the National Academy of Sciences 113 (33), 9304-9309, 2016
292016
Wnt signaling in development and tissue homeostasis
Z Steinhart, S Angers
Development 145 (11), dev146589, 2018
262018
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay
MV Gammons, TJ Rutherford, Z Steinhart, S Angers, M Bienz
J Cell Sci 129 (20), 3892-3902, 2016
262016
Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
Cell reports 27 (3), 971-986. e9, 2019
52019
Systematic discovery and classification of human cell line essential genes
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, S Angers, ...
bioRxiv, 015412, 2015
42015
A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
Z Pavlovic, JJ Adams, LL Blazer, AK Gakhal, N Jarvik, Z Steinhart, ...
MAbs 10 (8), 1157-1167, 2018
32018
Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ...
Nature medicine 23 (11), 1384, 2017
12017
Abstract IA13: Inhibiting the Wnt pathway with selective anti-Frizzled synthetic antibodies
Z Steinhart, T Hart, S Sidhu, J Moffat, S Angers
Molecular Cancer Research 14 (4 Supplement), IA13-IA13, 2016
12016
Frizzled protein-binding agents and methods of use thereof
G Pan, J Moffat, S Sidhu, S Angers, Z Steinhart, X Wang
US Patent App. 16/073,198, 2019
2019
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
Y Tao, M Mis, L Blazer, M Ustav
eLife 8, 2019
2019
Single molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation
W Ma, M Chen, H Kang, Z Steinhart, S Angers, X He, MW Kirschner
bioRxiv, 624882, 2019
2019
SPOT-009 Identification of novel hippo pathway regulators using a genome wide CRISPR screen
S Sen, S Mis, Z Steinhart, S Angers, L Attisano
ESMO Open 3 (Suppl 2), A19-A19, 2018
2018
A Genome-Wide CRISPR-Cas9 Screen Identifies Importin-β11 as a Required Factor for β-catenin Signaling in Colon Cancer
M Mis, Z Steinhart, S Angers
The FASEB Journal 32 (1_supplement), 804.11-804.11, 2018
2018
Identification of FZD5 as Genetic Vulnerability in RNF43 Mutant Cancer
Z Steinhart, Z Pavlovic, M Chandrashekhar, K Mascall, T Hart, X Wang, ...
The FASEB Journal 32 (1_supplement), 804.31-804.31, 2018
2018
The functional genomic circuitry of human glioblastoma stem cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
2018
Abstract PR03: High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, G Macleod, ...
Cancer Research 76 (3 Supplement), PR03-PR03, 2016
2016
A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer.
Z Steinhart, T Hart, M Chandrashekhar, Z Pavlovic, M Robitaille, X Wang, ...
bioRxiv, 041996, 2016
2016
The system can't perform the operation now. Try again later.
Articles 1–19