Assistant Professor, University of Tennessee Health Science Center
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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
C Kuscu, S Arslan, R Singh, J Thorpe, M Adli
Nature biotechnology 32 (7), 677-683, 2014
CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations
C Kuscu, M Parlak, T Tufan, J Yang, K Szlachta, X Wei, R Mammadov, ...
Nature methods 14 (7), 710-712, 2017
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
O Abdel-Wahab, J Gao, M Adli, A Dey, T Trimarchi, YR Chung, C Kuscu, ...
Journal of Experimental Medicine 210 (12), 2641-2659, 2013
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
R Singh, C Kuscu, A Quinlan, Y Qi, M Adli
Nucleic acids research 43 (18), e118-e118, 2015
Live cell imaging of low-and non-repetitive chromosome loci using CRISPR-Cas9
P Qin, M Parlak, C Kuscu, J Bandaria, M Mir, K Szlachta, R Singh, ...
Nature communications 8 (1), 14725, 2017
Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration
K Zarrabi, A Dufour, J Li, C Kuscu, A Pulkoski-Gross, J Zhi, Y Hu, ...
Journal of Biological Chemistry 286 (38), 33167-33177, 2011
miR-181a-5p inhibits cancer cell migration and angiogenesis via downregulation of matrix metalloproteinase-14
Y Li, C Kuscu, A Banach, Q Zhang, A Pulkoski-Gross, D Kim, J Liu, E Roth, ...
Cancer research 75 (13), 2674-2685, 2015
Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides
A Dufour, S Zucker, NS Sampson, C Kuscu, J Cao
Journal of Biological Chemistry 285 (46), 35944-35956, 2010
Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9
A Dufour, NS Sampson, J Li, C Kuscu, RC Rizzo, JL DeLeon, J Zhi, ...
Cancer research 71 (14), 4977-4988, 2011
Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration
NA Evensen, C Kuscu, HL Nguyen, K Zarrabi, A Dufour, P Kadam, Y Hu, ...
Journal of the National Cancer Institute 105 (18), 1402-1416, 2013
Small molecule inhibitor of CBFβ-RUNX binding for RUNX transcription factor driven cancers
A Illendula, J Gilmour, J Grembecka, VSS Tirumala, A Boulton, ...
EBioMedicine 8, 117-131, 2016
CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
K Szlachta, C Kuscu, T Tufan, SJ Adair, S Shang, AD Michaels, ...
Nature communications 9 (1), 4275, 2018
Transcriptional and Epigenetic Regulation of KIAA1199 Gene Expression in Human Breast Cancer
C Kuscu, N Evensen, D Kim, YJ Hu, S Zucker, J Cao
Public Library of Science 7 (9), e44661, 2012
Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells
X Wei, J Yang, SJ Adair, H Ozturk, C Kuscu, KY Lee, WJ Kane, PE O’Hara, ...
Proceedings of the National Academy of Sciences 117 (45), 28068-28079, 2020
Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)
NA Evensen, Y Li, C Kuscu, J Liu, J Cathcart, A Banach, Q Zhang, E Li, ...
Oncotarget 6 (24), 20723, 2015
Two distinct categories of focal deletions in cancer genomes
M Rajaram, J Zhang, T Wang, J Li, C Kuscu, H Qi, M Kato, V Grubor, ...
PLoS One 8 (6), e66264, 2013
CRISPR-Cas9-AID base editor is a powerful gain-of-function screening tool
C Kuscu, M Adli
Nature methods 13 (12), 983-984, 2016
Temporal and spatial epigenome editing allows precise gene regulation in mammalian cells
C Kuscu, R Mammadov, A Czikora, H Unlu, T Tufan, NL Fischer, S Arslan, ...
Journal of molecular biology 431 (1), 111-121, 2019
CEMIP upregulates BiP to promote breast cancer cell survival in hypoxia
A Banach, YP Jiang, E Roth, C Kuscu, J Cao, RZ Lin
Oncotarget 10 (42), 4307, 2019
FTY720 regulates mitochondria biogenesis in dendritic cells to prevent kidney ischemic reperfusion injury
TV Rousselle, C Kuscu, C Kuscu, K Schlegel, LP Huang, M Namwanje, ...
Frontiers in Immunology 11, 1278, 2020
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