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Nesli Ece Sen
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The distinct genetic pattern of ALS in Turkey and novel mutations
A Özoğuz, Ö Uyan, G Birdal, C Iskender, E Kartal, S Lahut, Ö Ömür, ...
Neurobiology of aging 36 (4), 1764. e9-1764. e18, 2015
1072015
Ataxin-2 (Atxn2)-knock-out mice show branched chain amino acids and fatty acids pathway alterations
D Meierhofer, M Halbach, NE Şen, S Gispert, G Auburger
Molecular & cellular proteomics 15 (5), 1728-1739, 2016
912016
Efficient prevention of neurodegenerative diseases by depletion of starvation response factor Ataxin-2
G Auburger, NE Sen, D Meierhofer, AN Başak, AD Gitler
Trends in neurosciences 40 (8), 507-516, 2017
652017
Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels
NE Sen, J Drost, S Gispert, S Torres-Odio, E Damrath, M Klinkenberg, ...
Neurobiology of disease 96, 115-126, 2016
372016
Elevated global DNA methylation is not exclusive to amyotrophic lateral sclerosis and is also observed in spinocerebellar ataxia types 1 and 2
H Hamzeiy, D Savaş, C Tunca, NE Şen, A Gündoğdu Eken, I Şahbaz, ...
Neurodegenerative Diseases 18 (1), 38-48, 2018
362018
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation
NE Sen, J Canet-Pons, MV Halbach, A Arsovic, U Pilatus, WH Chae, ...
Neurobiology of disease 132, 104559, 2019
342019
Quantitative global proteomics of yeast PBP1 deletion mutants and their stress responses identifies glucose metabolism, mitochondrial, and stress granule changes
G Seidel, D Meierhofer, NE Şen, A Guenther, S Krobitsch, G Auburger
Journal of proteome research 16 (2), 504-515, 2017
312017
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression
J Canet-Pons, NE Sen, A Arsović, LE Almaguer-Mederos, MV Halbach, ...
Neurobiology of Disease 152, 105289, 2021
282021
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated
MV Halbach, T Stehning, E Damrath, M Jendrach, NE Şen, AN Başak, ...
PLoS One 10 (3), e0121089, 2015
262015
In human and mouse spino-cerebellar tissue, ataxin-2 expansion affects ceramide-sphingomyelin metabolism
NE Sen, A Arsovic, D Meierhofer, S Brodesser, C Oberschmidt, ...
International journal of molecular sciences 20 (23), 5854, 2019
222019
Mid-Gestation lethality of Atxn2l-Ablated Mice
J Key, PN Harter, NE Sen, E Gradhand, G Auburger, S Gispert
International journal of molecular sciences 21 (14), 5124, 2020
172020
SerThr-PhosphoProteome of brain from aged PINK1-KO+ A53T-SNCA mice reveals pT1928-MAP1B and pS3781-ANK2 deficits, as hub between autophagy and synapse changes
G Auburger, S Gispert, S Torres-Odio, M Jendrach, N Brehm, ...
International journal of molecular sciences 20 (13), 3284, 2019
172019
Systematic surveys of iron homeostasis mechanisms reveal ferritin superfamily and nucleotide surveillance regulation to be modified by PINK1 absence
J Key, NE Sen, A Arsović, S Krämer, R Hülse, NN Khan, D Meierhofer, ...
Cells 9 (10), 2229, 2020
142020
Mouse ataxin-2 expansion downregulates CamKII and other calcium signaling factors, impairing granule—Purkinje neuron synaptic strength
A Arsović, MV Halbach, J Canet-Pons, D Esen-Sehir, C Döring, ...
International journal of molecular sciences 21 (18), 6673, 2020
142020
Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database
C Tunca, T Şeker, F Akcimen, C Coşkun, E Bayraktar, R Palvadeau, S Zor, ...
Human mutation 41 (8), e7-e45, 2020
132020
Poly (A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates
S Boeynaems, Y Dorone, Y Zhuang, V Shabardina, G Huang, A Marian, ...
Molecular cell 83 (12), 2020-2034. e6, 2023
122023
The complex genetic landscape of hereditary ataxias in Turkey and implications in clinical practice
A Vural, G Şimşir, Ş Tekgül, C Koçoğlu, F Akcimen, E Kartal, NE Şen, ...
Movement Disorders 36 (7), 1676-1688, 2021
122021
PINK1 and Ataxin-2 as modifiers of growth
NE Sen, S Gispert, G Auburger
Oncotarget 8 (20), 32382, 2017
72017
In spino-cerebellar tissue, Ataxin-2 expansion affects ceramide-sphingomyelin metabolism
NE Sen, A Arsovic, D Meierhofer, S Brodesser, C Oberschmidt, ...
Preprints, 2019
12019
Iron depletion reduces Abce1 transcripts while inducing the mitophagy factors Pink1 and Parkin
J Key, NE Sen, A Arsovic, S Krämer, R Hülse, S Gispert-Sanchez, ...
Preprints, 2019
12019
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