Simon Hirota
Simon Hirota
Associate Professor, Dept. of Physiology & Pharmacology, University of Calgary
Verified email at - Homepage
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Intravascular danger signals guide neutrophils to sites of sterile inflammation
B McDonald, K Pittman, GB Menezes, SA Hirota, I Slaba, ...
Science 330 (6002), 362-366, 2010
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
A Vilaysane, J Chun, ME Seamone, W Wang, R Chin, S Hirota, Y Li, ...
Journal of the American Society of Nephrology 21 (10), 1732-1744, 2010
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
SA Hirota, J Ng, A Lueng, M Khajah, K Parhar, Y Li, V Lam, MS Potentier, ...
Inflammatory bowel diseases 17 (6), 1359-1372, 2011
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
BD Gulbransen, M Bashashati, SA Hirota, X Gui, JA Roberts, ...
Nature medicine 18 (4), 600-604, 2012
Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
J Ng, SA Hirota, O Gross, Y Li, A Ulke–Lemee, MS Potentier, LP Schenck, ...
Gastroenterology 139 (2), 542-552. e3, 2010
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ...
Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β
NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ...
Experimental physiology 98 (2), 462-472, 2013
Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery
YJ Gao, S Hirota, DW Zhang, LJ Janssen, RMKW Lee
British journal of pharmacology 138 (6), 1085-1092, 2003
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
FA Vicentini, CM Keenan, LE Wallace, C Woods, JB Cavin, AR Flockton, ...
Microbiome 9, 1-24, 2021
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
KL Flannigan, VL Ngo, D Geem, A Harusato, SA Hirota, CA Parkos, ...
Mucosal immunology 10 (3), 673-684, 2017
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
SA Hirota, K Fines, J Ng, D Traboulsi, J Lee, E Ihara, Y Li, WG Willmore, ...
Gastroenterology 139 (1), 259-269. e3, 2010
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
M El-Daly, VKP Venu, M Saifeddine, K Mihara, S Kang, PWM Fedak, ...
Vascular pharmacology 109, 56-71, 2018
Ionic mechanisms and Ca2+ handling in airway smooth muscle
S Hirota, P Helli, LJ Janssen
European Respiratory Journal 30 (1), 114-133, 2007
The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection
X Sun, SA Hirota
Molecular immunology 63 (2), 193-202, 2015
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
J Terc, A Hansen, L Alston, SA Hirota
European Journal of Pharmaceutical Sciences 55, 12-19, 2014
Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity
MR Taylor, KL Flannigan, H Rahim, A Mohamud, IA Lewis, SA Hirota, ...
Science advances 5 (8), eaax2358, 2019
The reverse mode of the Na+/Ca2+ exchanger provides a source of Ca2+ for store refilling following agonist-induced Ca2+ mobilization
S Hirota, E Pertens, LJ Janssen
American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (2 …, 2007
Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue
JA Cotton, JP Motta, LP Schenck, SA Hirota, PL Beck, AG Buret
PloS one 9 (10), e109087, 2014
Inflammatory bowel disease cause-specific mortality: a primer for clinicians
Z Kassam, S Belga, I Roifman, S Hirota, H Jijon, GG Kaplan, S Ghosh, ...
Inflammatory bowel diseases 20 (12), 2483-2492, 2014
Pregnane X receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression …
A Garg, A Zhao, SL Erickson, S Mukherjee, AJ Lau, L Alston, TKH Chang, ...
Journal of Pharmacology and Experimental Therapeutics 359 (1), 91-101, 2016
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