Simon Hirota
Simon Hirota
Associate Professor, Dept. of Physiology & Pharmacology, University of Calgary
Verified email at ucalgary.ca - Homepage
TitleCited byYear
Intravascular danger signals guide neutrophils to sites of sterile inflammation
B McDonald, K Pittman, GB Menezes, SA Hirota, I Slaba, ...
Science 330 (6002), 362-366, 2010
9012010
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
A Vilaysane, J Chun, ME Seamone, W Wang, R Chin, S Hirota, Y Li, ...
Journal of the American Society of Nephrology 21 (10), 1732-1744, 2010
3342010
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
SA Hirota, J Ng, A Lueng, M Khajah, K Parhar, Y Li, V Lam, MS Potentier, ...
Inflammatory bowel diseases 17 (6), 1359-1372, 2010
2962010
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
BD Gulbransen, M Bashashati, SA Hirota, X Gui, JA Roberts, ...
Nature medicine 18 (4), 600, 2012
2702012
Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
J Ng, SA Hirota, O Gross, Y Li, A Ulke–Lemee, MS Potentier, LP Schenck, ...
Gastroenterology 139 (2), 542-552. e3, 2010
1622010
Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery
YJ Gao, S Hirota, DW Zhang, LJ Janssen, RMKW Lee
British journal of pharmacology 138 (6), 1085-1092, 2003
1302003
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ...
Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012
1292012
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β
NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ...
Experimental physiology 98 (2), 462-472, 2013
1072013
Ionic mechanisms and Ca2+ handling in airway smooth muscle
S Hirota, P Helli, LJ Janssen
European Respiratory Journal 30 (1), 114-133, 2007
732007
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
SA Hirota, K Fines, J Ng, D Traboulsi, J Lee, E Ihara, Y Li, WG Willmore, ...
Gastroenterology 139 (1), 259-269. e3, 2010
702010
The reverse mode of the Na+/Ca2+ exchanger provides a source of Ca2+ for store refilling following agonist-induced Ca2+ mobilization
S Hirota, E Pertens, LJ Janssen
American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (2 …, 2007
642007
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
J Terc, A Hansen, L Alston, SA Hirota
European Journal of Pharmaceutical Sciences 55, 12-19, 2014
562014
The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection
X Sun, SA Hirota
Molecular immunology 63 (2), 193-202, 2015
502015
Store-refilling involves both L-type calcium channels and reverse-mode sodium–calcium exchange in airway smooth muscle
S Hirota, LJ Janssen
European Respiratory Journal 30 (2), 269-278, 2007
492007
Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue
JA Cotton, JP Motta, LP Schenck, SA Hirota, PL Beck, AG Buret
PloS one 9 (10), e109087, 2014
382014
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
KL Flannigan, VL Ngo, D Geem, A Harusato, SA Hirota, CA Parkos, ...
Mucosal immunology 10 (3), 673, 2017
372017
Intracellular Cl fluxes play a novel role in Ca2+ handling in airway smooth muscle
S Hirota, N Trimble, E Pertens, LJ Janssen
American Journal of Physiology-Lung Cellular and Molecular Physiology 290 (6 …, 2006
362006
Inflammatory bowel disease cause-specific mortality: a primer for clinicians
Z Kassam, S Belga, I Roifman, S Hirota, H Jijon, GG Kaplan, S Ghosh, ...
Inflammatory bowel diseases 20 (12), 2483-2492, 2014
352014
Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease
SA Hirota, PL Beck, JA MacDonald
Recent patents on inflammation & allergy drug discovery 3 (1), 1-16, 2009
352009
Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium …
SA Hirota, V Iablokov, SE Tulk, LP Schenck, H Becker, J Nguyen, ...
Infection and immunity 80 (12), 4474-4484, 2012
322012
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Articles 1–20