| Intravascular danger signals guide neutrophils to sites of sterile inflammation B McDonald, K Pittman, GB Menezes, SA Hirota, I Slaba, ... Science 330 (6002), 362-366, 2010 | 873 | 2010 |
| The NLRP3 inflammasome promotes renal inflammation and contributes to CKD A Vilaysane, J Chun, ME Seamone, W Wang, R Chin, S Hirota, Y Li, ... Journal of the American Society of Nephrology 21 (10), 1732-1744, 2010 | 318 | 2010 |
| NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis SA Hirota, J Ng, A Lueng, M Khajah, K Parhar, Y Li, V Lam, MS Potentier, ... Inflammatory bowel diseases 17 (6), 1359-1372, 2010 | 286 | 2010 |
| Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis BD Gulbransen, M Bashashati, SA Hirota, X Gui, JA Roberts, ... Nature medicine 18 (4), 600, 2012 | 264 | 2012 |
| Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome J Ng, SA Hirota, O Gross, Y Li, A Ulke–Lemee, MS Potentier, LP Schenck, ... Gastroenterology 139 (2), 542-552. e3, 2010 | 158 | 2010 |
| Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery YJ Gao, S Hirota, DW Zhang, LJ Janssen, RMKW Lee British journal of pharmacology 138 (6), 1085-1092, 2003 | 127 | 2003 |
| The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter JA Hirota, SA Hirota, SM Warner, D Stefanowicz, F Shaheen, PL Beck, ... Journal of Allergy and Clinical Immunology 129 (4), 1116-1125. e6, 2012 | 120 | 2012 |
| The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ... Experimental physiology 98 (2), 462-472, 2013 | 106 | 2013 |
| Ionic mechanisms and Ca2+ handling in airway smooth muscle S Hirota, P Helli, LJ Janssen European Respiratory Journal 30 (1), 114-133, 2007 | 72 | 2007 |
| Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury SA Hirota, K Fines, J Ng, D Traboulsi, J Lee, E Ihara, Y Li, WG Willmore, ... Gastroenterology 139 (1), 259-269. e3, 2010 | 68 | 2010 |
| The reverse mode of the Na+/Ca2+ exchanger provides a source of Ca2+ for store refilling following agonist-induced Ca2+ mobilization S Hirota, E Pertens, LJ Janssen American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (2 …, 2007 | 64 | 2007 |
| Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis J Terc, A Hansen, L Alston, SA Hirota European Journal of Pharmaceutical Sciences 55, 12-19, 2014 | 51 | 2014 |
| The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection X Sun, SA Hirota Molecular immunology 63 (2), 193-202, 2015 | 49 | 2015 |
| Store-refilling involves both L-type calcium channels and reverse-mode sodium–calcium exchange in airway smooth muscle S Hirota, LJ Janssen European Respiratory Journal 30 (2), 269-278, 2007 | 48 | 2007 |
| Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue JA Cotton, JP Motta, LP Schenck, SA Hirota, PL Beck, AG Buret PloS one 9 (10), e109087, 2014 | 36 | 2014 |
| Intracellular Cl− fluxes play a novel role in Ca2+ handling in airway smooth muscle S Hirota, N Trimble, E Pertens, LJ Janssen American Journal of Physiology-Lung Cellular and Molecular Physiology 290 (6 …, 2006 | 36 | 2006 |
| IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria KL Flannigan, VL Ngo, D Geem, A Harusato, SA Hirota, CA Parkos, ... Mucosal immunology 10 (3), 673, 2017 | 35 | 2017 |
| Inflammatory bowel disease cause-specific mortality: a primer for clinicians Z Kassam, S Belga, I Roifman, S Hirota, H Jijon, GG Kaplan, S Ghosh, ... Inflammatory bowel diseases 20 (12), 2483-2492, 2014 | 35 | 2014 |
| Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease SA Hirota, PL Beck, JA MacDonald Recent patents on inflammation & allergy drug discovery 3 (1), 1-16, 2009 | 34 | 2009 |
| Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium … SA Hirota, V Iablokov, SE Tulk, LP Schenck, H Becker, J Nguyen, ... Infection and immunity 80 (12), 4474-4484, 2012 | 32 | 2012 |
Paul L. BeckProfessor Medicine, Division of Gastroenterology, University of Calgary.Verified email at ucalgary.ca