H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 467 | 2018 |
Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018 | 379 | 2018 |
Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint S Fumagalli, VV Ivanenkov, T Teng, G Thomas Genes & development 26 (10), 1028-1040, 2012 | 222 | 2012 |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex T Teng, JHC Tsai, X Puyang, M Seiler, S Peng, S Prajapati, D Aird, ... Nature communications 8 (1), 15522, 2017 | 133 | 2017 |
Growth control and ribosomopathies T Teng, G Thomas, CA Mercer Current opinion in genetics & development 23 (1), 63-71, 2013 | 125 | 2013 |
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action LI Finci, X Zhang, X Huang, Q Zhou, J Tsai, T Teng, A Agrawal, B Chan, ... Genes & development 32 (3-4), 309-320, 2018 | 110 | 2018 |
Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity T Teng, CA Mercer, P Hexley, G Thomas, S Fumagalli Molecular and cellular biology 33 (23), 4660-4671, 2013 | 101 | 2013 |
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators D Aird, T Teng, CL Huang, E Pazolli, D Banka, K Cheung-Ong, C Eifert, ... Nature communications 10 (1), 137, 2019 | 68 | 2019 |
Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation Z Chang, Q Zhang, Q Feng, J Xu, T Teng, Q Luan, C Shan, Y Hu, ... Developmental biology 347 (2), 384-391, 2010 | 65 | 2010 |
Cancer genome atlas research N, Buonamici S, Yu L: somatic mutational landscape of splicing factor genes and their functional consequences across 33 Cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith Cell Rep 23 (1), 282-296, 2018 | 32 | 2018 |
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. Cell Rep 23: 282–296. e4 M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith | 8 | 2018 |
Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types. Cell Rep. 2018; 23 (1): 282-96. e4 M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, P Smith, ... | 8 | |
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. Cell Rep. 2018; 23: 282–296. e4 M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... doi. org/10.1016/j. celre p 88, 2018 | 6 | 2018 |
Spliceosome mutations and uses thereof M Warmuth, X Puyang, T Teng, P Zhu US Patent App. 16/494,202, 2020 | | 2020 |
Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators D Aird, T Teng, CL Huang, E Pazolli, D Banka, K Cheung-Ong, C Eifert, ... Cancer Research 79 (13_Supplement), 281-281, 2019 | | 2019 |
A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex T Teng, J Tsai, X Puyang, M Seiler, S Peng, D Aird, S Buonamici, B Caleb, ... Cancer Research 77 (13_Supplement), 126-126, 2017 | | 2017 |
Identification of PHF5A as a common cellular target of splicing-modulating chemical probes T Teng, X Puyang, S Peng, J Feala, B Chan, J Tsai, B Caleb, C Karr, ... Cancer Research 76 (14_Supplement), 3013-3013, 2016 | | 2016 |