Melissa L Perreault
Melissa L Perreault
Associate Professor in Neuroscience, University of Guelph, Department of Biomedical Sciences
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Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
P Seeman, D Weinshenker, R Quirion, LK Srivastava, SK Bhardwaj, ...
Proceedings of the National Academy of Sciences 102 (9), 3513-3518, 2005
Psychosis pathways converge via D2High dopamine receptors
P Seeman, J Schwarz, JF Chen, H Szechtman, M Perreault, GS McKnight, ...
Synapse 60 (4), 319-346, 2006
Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth
A Hasbi, T Fan, M Alijaniaram, T Nguyen, ML Perreault, BF O'Dowd, ...
Proceedings of the National Academy of Sciences 106 (50), 21377-21382, 2009
The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia
ML Perreault, A Hasbi, M Alijaniaram, T Fan, G Varghese, PJ Fletcher, ...
Journal of Biological Chemistry 285 (47), 36625-36634, 2010
Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance
ML Perreault, A Hasbi, BF O'dowd, SR George
Neuropsychopharmacology 39 (1), 156-168, 2014
The dopamine D1–D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in basal ganglia
ML Perreault, A Hasbi, BF O’Dowd, SR George
Frontiers in neuroanatomy 5, 31, 2011
Dopamine D1–D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2
ML Perreault, T Fan, M Alijaniaram, BF O'Dowd, SR George
PloS one 7 (3), e33348, 2012
Activation of dopamine D1-D2 receptor complex attenuates cocaine reward and reinstatement of cocaine-seeking through inhibition of DARPP-32, ERK, and ΔFosB
A Hasbi, ML Perreault, MYF Shen, T Fan, AA Grace, SR George
Frontiers in pharmacology 8, 300887, 2018
A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism
A Hasbi, ML Perreault, MYF Shen, L Zhang, R To, T Fan, T Nguyen, X Ji, ...
The FASEB Journal 28 (11), 4806, 2014
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression-and anxiety-like behaviors
A Hasbi, T Nguyen, H Rahal, JD Manduca, S Miksys, RF Tyndale, ...
Biology of sex differences 11, 1-17, 2020
A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex
ML Perreault, J Jones-Tabah, BF O'Dowd, SR George
International Journal of Neuropsychopharmacology 16 (2), 477-483, 2013
Sex differences in dopamine receptors and relevance to neuropsychiatric disorders
OOF Williams, M Coppolino, SR George, ML Perreault
Brain sciences 11 (9), 1199, 2021
Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder
A Dvorkin, ML Perreault, H Szechtman
Behavioural brain research 169 (2), 303-311, 2006
Dopamine receptor homooligomers and heterooligomers in schizophrenia
ML Perreault, BF O’Dowd, SR George
CNS neuroscience & therapeutics 17 (1), 52-57, 2011
Rapid anti-depressant and anxiolytic actions following dopamine D1–D2 receptor heteromer inactivation
MYF Shen, ML Perreault, FR Bambico, J Jones-Tabah, M Cheung, T Fan, ...
European Neuropsychopharmacology 25 (12), 2437-2448, 2015
Hormonal regulation of circuit function: sex, systems and depression
RK Thériault, ML Perreault
Biology of sex differences 10, 1-14, 2019
Disruption of a dopamine receptor complex amplifies the actions of cocaine
ML Perreault, A Hasbi, MYF Shen, T Fan, G Navarro, PJ Fletcher, ...
European Neuropsychopharmacology 26 (9), 1366-1377, 2016
Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: pre-and postsynaptic mechanisms
ML Perreault, D Graham, L Bisnaire, J Simms, S Hayton, H Szechtman
Neuropsychopharmacology 31 (9), 1967-1981, 2006
Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).
ML Perreault, P Seeman, H Szechtman
Behavioral neuroscience 121 (5), 976, 2007
Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer
ML Perreault, MYF Shen, T Fan, SR George
Neuroscience 285, 194-203, 2015
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