| Efficient restoration of the dystrophin gene reading frame and protein structure in DMD myoblasts using the CinDel method JP Iyombe-Engembe, DL Ouellet, X Barbeau, J Rousseau, ... Molecular Therapy-Nucleic Acids 5, 2016 | 96 | 2016 |
| Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia S Krishnamurthy, C Wohlford-Lenane, S Kandimalla, G Sartre, ... Nature communications 10 (1), 4906, 2019 | 94 | 2019 |
| Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells T Del’Guidice, JP Lepetit-Stoffaes, LJ Bordeleau, J Roberge, V Théberge, ... PloS one 13 (4), e0195558, 2018 | 82 | 2018 |
| CRISPR-induced deletion with SaCas9 restores dystrophin expression in dystrophic models in vitro and in vivo BL Duchêne, K Cherif, JP Iyombe-Engembe, A Guyon, J Rousseau, ... Molecular Therapy 26 (11), 2604-2616, 2018 | 73 | 2018 |
| Stereocontrolled approach to bromofluoroalkenes and their use for the synthesis of tri-and tetrasubstituted fluoroalkenes G Landelle, PA Champagne, X Barbeau, JF Paquin Organic Letters 11 (3), 681-684, 2009 | 65 | 2009 |
| Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-(m-carbamoylbenzyl)-estradiol Derivatives R Maltais, D Ayan, A Trottier, X Barbeau, P Lagüe, JE Bouchard, ... Journal of medicinal chemistry 57 (1), 204-222, 2014 | 43 | 2014 |
| Quinazoline‐4‐piperidine sulfamides are specific inhibitors of human NPP 1 and prevent pathological mineralization of valve interstitial cells EE Shayhidin, E Forcellini, MC Boulanger, A Mahmut, S Dautrey, ... British journal of pharmacology 172 (16), 4189-4199, 2015 | 39 | 2015 |
| Viral polymerase inhibitors T Stammers, X Barbeau, P Beaulieu, M Bertrand-laperle, C Brochu, ... US Patent App. 12/883,677, 2011 | 34 | 2011 |
| Antibiotic resistance due to an unusual ColE1-type replicon plasmid in Aeromonas salmonicida AT Vincent, JG Emond-Rheault, X Barbeau, SA Attéré, M Frenette, ... Microbiology 162 (6), 942-953, 2016 | 33 | 2016 |
| Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties C Ouellet, R Maltais, É Ouellet, X Barbeau, P Lagüe, D Poirier European Journal of Medicinal Chemistry 119, 169-182, 2016 | 30 | 2016 |
| Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1 E Forcellini, S Boutin, CA Lefebvre, EE Shayhidin, MC Boulanger, ... European Journal of Medicinal Chemistry 147, 130-149, 2018 | 25 | 2018 |
| Interfacial supramolecular biomimetic epoxidation catalysed by cyclic dipeptides C Berube, X Barbeau, S Cardinal, PL Boudreault, C Bouchard, N Delcey, ... Supramolecular Chemistry 29 (5), 330-349, 2017 | 24 | 2017 |
| Revisiting the Juliá–Colonna enantioselective epoxidation: supramolecular catalysis in water C Bérubé, X Barbeau, P Lagüe, N Voyer Chemical communications 53 (37), 5099-5102, 2017 | 21 | 2017 |
| Extended linkers improve the detection of protein-protein interactions (PPIs) by dihydrofolate reductase protein-fragment complementation assay (DHFR PCA) in living cells AÈ Chrétien, I Gagnon-Arsenault, AK Dubé, X Barbeau, PC Després, ... Molecular & Cellular Proteomics 17 (2), 373-383, 2018 | 19 | 2018 |
| Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity R Maltais, A Trottier, X Barbeau, P Laguee, M Perreault, JF Theriault, ... The journal of steroid biochemistry and molecular biology 161, 24-35, 2016 | 19 | 2016 |
| Identification of fused 16β, 17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors R Maltais, A Trottier, A Delhomme, X Barbeau, P Lagüe, D Poirier European Journal of Medicinal Chemistry 93, 470-480, 2015 | 18 | 2015 |
| Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1 A Trottier, R Maltais, D Ayan, X Barbeau, J Roy, M Perreault, R Poulin, ... Biochemical pharmacology 144, 149-161, 2017 | 17 | 2017 |
| Aeromonas salmonicida Ati2 is an effector protein of the type three secretion system S Dallaire-Dufresne, X Barbeau, D Sarty, KH Tanaka, AM Denoncourt, ... Microbiology 159 (Pt_9), 1937-1945, 2013 | 17 | 2013 |
| Novel chiral N, N′-dimethyl-1, 4-piperazines with metal binding abilities C Bérubé, S Cardinal, PL Boudreault, X Barbeau, N Delcey, M Giguère, ... Tetrahedron 71 (42), 8077-8084, 2015 | 15 | 2015 |
| Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ C Carpentier, X Barbeau, J Azelmat, K Vaillancourt, D Grenier, P Lagüe, ... Bioorganic & Medicinal Chemistry 26 (22), 5845-5851, 2018 | 14 | 2018 |
Patrick LagueDépartement de Biochimie, de Microbiology et de Bio-informatique, Université LavalVerified email at bcm.ulaval.ca
